Patents by Inventor Hirohiko ISE

Hirohiko ISE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • O-GLCNACYLATED PROTEIN-LIKE SUBSTANCE AND FIBROSIS THERAPEUTIC DRUG CONTAINING SAME
    Publication number: 20220389047
    Abstract: An O-GlcNAcylated protein-like substance having an N-acetylglucosamine unit, and at least one unit selected from the group consisting of a carboxy group-containing radically polymerizable unit, a styrene unit, a polyethylenimine unit, a poly-L-lysine unit, and a biotin unit; and a fibrosis therapeutic drug containing the O-GlcNAcylated protein-like substance.
    Type: Application
    Filed: November 13, 2020
    Publication date: December 8, 2022
    Inventors: Hirohiko ISE, Saori MATSUO
  • N-acetylglucosamine sugar chain group-containing compound, carrier compound for drug delivery, drug preparation, and drug delivery system
    Patent number: 10471158
    Abstract: An N-acetylglucosamine sugar chain group-containing compound which can easily reach cells/sites on which a vimentin and/or desmin protein(s) is/are exposed, which compound has excellent affinity to N-acetylglucosamine sugar chain-recognizing proteins; a drug delivery carrier compound comprising the compound; a preparation using the drug delivery earner compound; and a drug delivery system; are provided. These are an N-acetylglucosamine sugar chain group-containing compound having a weight average molecular weight within the range of 15,000 to 100,000; a drug delivery carrier compound comprising the compound; a preparation using the drug delivery carrier compound; and a drug delivery system.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: November 12, 2019
    Assignee: SOMAR CORPORATION
    Inventor: Hirohiko Ise
  • Sugar chain-containing polymer, and sugar chain-containing polymer complex
    Patent number: 9617543
    Abstract: A sugar chain-containing polymer that enables targeting to the lesion area of liver fibrosis and is useful for imaging, diagnosis and therapy of liver fibrosis; and a sugar chain-containing polymer complex comprising the polymer as a carrier for an anionic substance useful fix therapy and the like; are provided. The polymer is a sugar chain-containing polymer which is a cationic polymer comprising an amine, which polymer comprises N-acetylglucosamine bound thereto. The polymer preferably has a disulfide bond. The polymer preferably has a structure in which polyethyleneimine is linked via a disulfide bond.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: April 11, 2017
    Assignees: SOMAR CORP., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Bong Hyun Chung, Hirohiko Ise, Toshihiro Akaike, Sun-Jung Kim
  • N-ACETYLGLUCOSAMINE SUGAR CHAIN GROUP-CONTAINING COMPOUND, CARRIER COMPOUND FOR DRUG DELIVERY, DRUG PREPARATION, AND DRUG DELIVERY SYSTEM
    Publication number: 20170095564
    Abstract: An N-acetylglucosamine sugar chain group-containing compound which can easily reach cells/sites on which a vimentin and/or desmin protein(s) is/are exposed, which compound has excellent affinity to N-acetylglucosamine sugar chain-recognizing proteins; a drug delivery carrier compound comprising the compound: a preparation using the drug delivery earner compound; and a drug delivery system; are provided. These are an N-acetylglucosamine sugar chain group-containing compound having a weight average molecular weight within the range of 15,000 to 100,000; a drug delivery carrier compound comprising the compound; a preparation using the drug delivery carrier compound; and a drug delivery system.
    Type: Application
    Filed: May 19, 2015
    Publication date: April 6, 2017
    Applicant: SOMAR CORPORATION
    Inventor: Hirohiko ISE
  • SUGAR CHAIN-CONTAINING POLYMER, AND SUGAR CHAIN-CONTAINING POLYMER COMPLEX
    Publication number: 20150148527
    Abstract: A sugar chain-containing polymer that enables targeting to the lesion area of liver fibrosis and is useful for imaging, diagnosis and therapy of liver fibrosis; and a sugar chain-containing polymer complex comprising the polymer as a carrier for an anionic substance useful fix therapy and the like; are provided. The polymer is a sugar chain-containing polymer which is a cationic polymer comprising an amine, which polymer comprises N-acetylglucosamine bound thereto. The polymer preferably has a disulfide bond. The polymer preferably has a structure in which polyethyleneimine is linked via a disulfide bond.
    Type: Application
    Filed: May 27, 2014
    Publication date: May 28, 2015
    Applicants: SOMAR Corp., KOREAN RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Bong Hyun CHUNG, Hirohiko ISE, Toshihiro AKAIKE, Sun-Jung KIM