Patents by Inventor Hirohiko Shimizu
Hirohiko Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11963433Abstract: The present invention provides an organic electroluminescence device capable of having not only a device lifetime comparable to that of an existing organic electroluminescence device but also a small thickness of smaller than 10 ?m and excellent flexibility. The present invention relates to an organic electroluminescence device having a structure including: an anode; a cathode on a substrate; and a laminate of multiple layers between the anode and the cathode, the device having a thickness of smaller than 10 ?m.Type: GrantFiled: December 6, 2019Date of Patent: April 16, 2024Assignees: The University of Tokyo, Nippon Hoso Kyokai, Nippon Shokubai Co., Ltd.Inventors: Takao Someya, Tomoyuki Yokota, Hirohiko Fukagawa, Takahisa Shimizu, Katsuyuki Morii, Tsuyoshi Goya, Kenji Kuwada
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Patent number: 8399414Abstract: The object of this invention is to provide a novel pharmaceutical composition for getting rid of pains and anxiety in patients. This invention relates to a pharmaceutical composition containing lactoferrin as an active ingredient. The composition of this invention is useful for treatment of at least one disease or condition selected from the group consisting of pains, including the phase 1 pain and the phase 2 pain, anxiety and stress. The composition is particularly beneficial to alleviating or getting rid of the pain and anxiety which significantly lower quality of life of patients with end-stage cancer. The composition of this invention is also useful for treatment of pains, including the phase 1 pain and the phase 2 pain, and inflammation which accompany arthritis or diseases in the junctions of bones (e.g. rheumatoid arthritis, osteoarthritis, frozen shoulder, sports injuries such as tennis elbow and baseball shoulder, and low back pain).Type: GrantFiled: January 17, 2003Date of Patent: March 19, 2013Assignee: NRL Pharma, Inc.Inventors: Etsumori Harada, Takashi Takeuchi, Kenichiro Hayashida, Kunio Ando, Hirohiko Shimizu
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Publication number: 20100032554Abstract: A neutron polarization apparatus is provided that provides a neutron beam polarized by an interaction between a spin of a neutron in an incident neutron beam and a magnetic field. The apparatus includes a quadrupole magnet (2) disposed around a passage of a neutron beam, a tubular neutron absorber (3) provided in the quadrupole magnet (2) along am axial direction of the neutron beam, and a solenoid coil (4) disposed at an exit of the quadrupole magnet (2), adiabatically coupling the quadrupole magnetic field produced by the quadrupole magnet (2) and applying a bipolar magnetic field. The neutron polarization apparatus can polarize a neutron with a high polarization unavailable in the prior art.Type: ApplicationFiled: November 1, 2006Publication date: February 11, 2010Inventors: Hirohiko Shimizu, Jun-ichi Suzuki, Takayuki Oku
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Patent number: 7450299Abstract: The light of a broad energy band can be observed by reflecting the light of the broad energy band, for example, the light from the visible light region to the x-ray region at a high reflectance respectively, by a composite telescope including a normal incidence optical system and an oblique incidence optical system. A broadband telescope comprise an oblique incidence optical system unit in which the light is obliquely incident on a surface part for reflecting the incident light, a normal incidence optical system unit in which the light is substantially vertically incident on a surface part for reflecting the incident light, and an analyzer for spectrum analysis of the light reflected by the surface part of the obliquely incidence optical system unit and the light reflected by the surface part of the normal incidence optical system unit.Type: GrantFiled: December 25, 2002Date of Patent: November 11, 2008Assignee: RikenInventors: Yoshiyuki Takizawa, Yoshiyuki Takahashi, Hirohiko Shimizu, Chiko Otani, Toshikazu Ebisuzaki
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Patent number: 7351952Abstract: An apparatus for controlling a neutron beam includes a plurality of columnar prisms 1 that are made of a material having a refractive index of less than 1 for a neutron beam, and are arranged so as to be multi-layered. The columnar prisms 1 each have an approximately right-triangle-shaped section, and are three-dimensionally multi-layered such that respective surfaces 1a, 1b, 1c of the columnar prisms are in parallel to one another. Stick-shaped members 5 are made of the above material, the stick-shaped members 5 are set in a plurality of grooves formed on a jig 6 that have the same shape, and upper surfaces of the grooves are flattened at the same time.Type: GrantFiled: June 3, 2003Date of Patent: April 1, 2008Assignee: RikenInventors: Shinya Morita, Hitoshi Ohmori, Yutaka Yamagata, Sei Moriyasu, Hirohiko Shimizu, Takayuki Oku
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Publication number: 20080014270Abstract: A pharmaceutical composition is provided having at least one kind to be selected from the group consisting of a lactoferrin group protein having lactoferrin and conalbumin, and an enzymatically decomposed product of the lactoferrin group protein having peptides corresponding to lactoferricin and lactoferricin of conalbumin as an active ingredient. The composition of the present invention can be used as an agent for improving lipid metabolism. Further, it is useful for treating hypercholesterolemia, hyper-neutral lipidemia, hyper-low density lipoprotein (LDL) cholesterolemia, hypo-high density lipoprotein (HDL) cholesterolemia, obesity, fatty liver and cholesterol gallstone and lifestyle-related diseases such as severe obesity, hyperlipidemia, hypertension and type II diabetes. The composition of the present invention can improve basal metabolic rate.Type: ApplicationFiled: August 1, 2007Publication date: January 17, 2008Inventors: Etsumori HARADA, Takashi Takeuchi, Kunio Ando, Hirohiko Shimizu
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Publication number: 20060226350Abstract: An apparatus for controlling a neutron beam includes a plurality of columnar prisms 1 that are made of a material having a refractive index of less than 1 for a neutron beam, and are arranged so as to be multi-layered. The columnar prisms 1 each have an approximately right-triangle-shaped section, and are three-dimensionally multi-layered such that respective surfaces 1a, 1b, 1c of the columnar prisms are in parallel to one another. Stick-shaped members 5 are made of the above material, the stick-shaped members 5 are set in a plurality of grooves formed on a jig 6 that have the same shape, and upper surfaces of the grooves are flattened at the same time.Type: ApplicationFiled: June 3, 2003Publication date: October 12, 2006Applicant: RIKENInventors: Shinya Morita, Hitoshi Ohmori, Yutaka Yamagata, Hirohiko Shimizu, Takayuki Oku
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Publication number: 20050122603Abstract: The light of a broad energy band can be observed by reflecting the light of the broad energy band, for example, the light from the visible light region to the x-ray region at a high reflectance respectively, by a composite telescope including a normal incidence optical system and an oblique incidence optical system. A broadband telescope comprise an oblique incidence optical system unit in which the light is obliquely incident on a surface part for reflecting the incident light, a normal incidence optical system unit in which the light is substantially vertically incident on a surface part for reflecting the incident light, and an analyzer for spectrum analysis of the light reflected by the surface part of the obliquely incidence optical system unit and the light reflected by the surface part of the normal incidence optical system unit.Type: ApplicationFiled: December 25, 2002Publication date: June 9, 2005Inventors: Yoshiyuki Takizawa, Yoshiyuki Takahashi, Hirohiko Shimizu, Chiko Otani, Toshikazu Ebisuzaki
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Publication number: 20050119162Abstract: The object of this invention is to provide a novel pharmaceutical composition for getting rid of pains and anxiety in patients. This invention relates to a pharmaceutical composition containing lactoferrin as an active ingredient. The composition of this invention is useful for treatment of at least one disease or condition selected from the group consisting of pains, including the phase 1 pain and the phase 2 pain, anxiety and stress. The composition is particularly beneficial to alleviating or getting rid of the pain and anxiety which significantly lower quality of life of patients with end-stage cancer. The composition of this invention is also useful for treatment of pains, including the phase 1 pain and the phase 2 pain, and inflammation which accompany arthritis or diseases in the junctions of bones (e.g. rheumatoid arthritis, osteoarthritis, frozen shoulder, sports injuries such as tennis elbow and baseball shoulder, and low back pain).Type: ApplicationFiled: January 17, 2003Publication date: June 2, 2005Inventors: Etsumori Harada, Takashi Takeuchi, Kenichiro Hayashida, Kunio Ando, Hirohiko Shimizu
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Publication number: 20050020484Abstract: The present invention provides a pharmaceutical composition having at least one kind to be selected from the group consisting of a lactoferrin group protein comprising lactoferrin and conalbumin, and an enzymatically decomposed product of the lactoferrin group protein comprising peptides corresponding to lactoferricin and lactoferricin of conalbumin an active ingredient. The composition of the present invention can be used as an agent for improving lipid metabolism. Further, it is useful for treating hypercholesterolemia, hyper-neutral lipidemia, hyper-low density lipoprotein (LDL) cholesterolemia, hypo-high density lipoprotein (HDL) cholesterolemia, obesity, fatty liver and cholesterol gallstone and lifestyle-related diseases such as severe obesity, hyperlipidemia, hypertension and type II diabetes. The composition of the present invention can improve basal metabolic rate.Type: ApplicationFiled: December 27, 2002Publication date: January 27, 2005Inventors: Etsumori Harada, Takashi Takeuchi, Kunio Ando, Hirohiko Shimizu
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Patent number: 6580080Abstract: A neutron beam controlling apparatus includes a plurality of multilayered plate members, each having on one or both of its surfaces, one or more minute protruding portions. Each of the protruding portions is a long and narrow protrusion extending in an area-wise direction and having both an inclined surface that is inclined against the beam axis of neutron beam and serves as an incident plane or an outgoing plane for the neutron beam and a surface approximately normal to the plate member.Type: GrantFiled: March 7, 2000Date of Patent: June 17, 2003Assignee: RikenInventors: Hirohiko Shimizu, Takayuki Oku, Yuji Kawabata
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Patent number: 6444994Abstract: A rotating table 2 that holds a flat neutron lens component 1 and rotates about an axis of rotation Z, a circular-disk type of metal-bonded grinding wheel 3 with tapering surface 3a on the outer periphery thereof, a grinding wheel driving device 4 drives and rotates the grinding wheel around the axis A thereof, an electrode 5 with a surface close to the single tapering surface or the plurality of tapering surfaces of the grinding wheel, a power source 6 that applies an electrolytic voltage between the grinding wheel and the electrode, and a grinding fluid feeder 8 that supplies a conducting grinding fluid between the grinding wheel and the electrode are provided.Type: GrantFiled: August 30, 2000Date of Patent: September 3, 2002Assignees: RikenInventors: Hitoshi Ohmori, Yutaka Yamagata, Shinya Morita, Sei Moriyasu, Hirohiko Shimizu
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Patent number: 6421209Abstract: The present invention provides a disk drive apparatus for recording and/or playing back a signal onto and/or from a disk-shaped recording medium. The disk drive apparatus has a configuration comprising a head arm for supporting a magnetic head. The head arm is provided with an arm base made of a rigid material and a suspension implemented by a plate spring. Since in the configuration of the disk drive apparatus provided by the present invention includes a head arm which is provided with an arm base made of a rigid material and a suspension implemented by a plate spring, the length of the suspension can be shortened and the positional precision of the magnetic head can be assured with a high degree of reliability.Type: GrantFiled: April 3, 2001Date of Patent: July 16, 2002Assignee: Sony CorporationInventor: Hirohiko Shimizu
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Publication number: 20010012183Abstract: The present invention provides a disk drive apparatus for recording and/or playing back a signal onto and/or from a disk-shaped recording medium. The disk drive apparatus having a configuration comprising a head arm for supporting a magnetic head. The head arm is provided with an arm base made of a rigid material and a suspension implemented by a plate spring. Since in the configuration of the disk drive apparatus provided by the present invention includes a head arm which is provided with an arm base made of a rigid material and a suspension implemented by a plate spring, the length of the suspension can be shortened and the positional precision of the magnetic head can be assured with a high degree of reliability.Type: ApplicationFiled: April 3, 2001Publication date: August 9, 2001Applicant: SONY CORPORATIONInventor: Hirohiko Shimizu
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Patent number: 6256174Abstract: The present invention provides a disk drive apparatus for recording and/or playing back a signal onto and/or from a disk-shaped recording medium. The disk drive apparatus having a configuration comprising a head arm for supporting a magnetic head. The head arm is provided with an arm base made of a rigid material and a suspension implemented by a plate spring. Since in the configuration of the disk drive apparatus provided by the present invention includes a head arm which is provided with an arm base made of a rigid material and a suspension implemented by a plate spring, the length of the suspension can be shortened and the positional precision of the magnetic head can be assured with a high degree of reliability.Type: GrantFiled: March 12, 1999Date of Patent: July 3, 2001Assignee: Sony CorporationInventor: Hirohiko Shimizu
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Patent number: 6243237Abstract: A disk drive wherein a head raising and lowering arm is rotated around a pivot shaft of a slide plate by a cam action due to a cam groove of the head raising and lowering arm and a fixed guide shaft when the head raising and lowering arm is inserted in a head suspension by the slide plate, so that the head performs a soft landing from a head unloading position to a head loading position on a floppy disk.Type: GrantFiled: August 20, 1999Date of Patent: June 5, 2001Assignee: Sony CorporationInventors: Hirohiko Shimizu, Hideaki Kumagai
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Patent number: 6054708Abstract: The methods and apparatuses for the control of neutron beams are herewith presented. Through the application of the methods and apparatuses presented one can manipulate various characteristics of neutron beams such as shape, velocity, density, polarization and other traits. In general three sequential operations are performed on the neutron beam, although variations of these steps are described to suit various purposes. First, a neutron beam is passed through a gradient magnet field which causes rotation of the beam in phase space. Second, the spin direction of a neutron beam is reversed through the application of a spin flipper. Third, the neutron beam is compressed in the longitudinal direction of the neutron beam in phase space. This produces a neutron beam having small divergence in phase space. The resultant neutron beam corresponds to a thin dense beam in real space. Variations of this paradigm allow for the manipulation of many characteristics of neutron beams to suit ones purpose.Type: GrantFiled: March 3, 1998Date of Patent: April 25, 2000Assignee: The Institute of Physical and Chemical ResearchInventor: Hirohiko Shimizu
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Patent number: 5793564Abstract: An auto-loading system for recording medium cartridges is provided which permits the simple and reliable operation of rotating the recording medium cartridges between a magazine and a drive. The auto-loading system has a cartridge tray of an elevator which is moved upward and downward between a cartridge port of the drive and a cartridge insertion port and a cartridge ejection port of the magazine within an autoloader body so that a plurality of recording medium cartridges are rotated between the magazine and the drive by the operation of ejecting the recording medium cartridges into the cartridge tray from the cartridge ejection port of the magazine by a first cartridge ejecting mechanism and the operation of ejecting the recording medium cartridges into the cartridge port of the drive or the cartridge insertion port of the magazine from the cartridge tray by a second cartridge ejecting mechanism.Type: GrantFiled: February 1, 1996Date of Patent: August 11, 1998Assignee: Sony CorporationInventors: Hideo Nakase, Jo Nakagawa, Hirohiko Shimizu, Tsuyoshi Umemura, Akira Saito
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Patent number: 5661000Abstract: The present invention offers the serine protease exhibiting a biological activity which a polypeptide having an amino acid sequence shown in FIG. 1 shows, the serine protease precursor where a cleavable peptide or signal peptide connects with the N-terminal of the said serine protease, and the gene encoding them. The serine protease being useful in medical treatment fields can be manufactured in large quantities by the present invention.Moreover, the present invention offers the DNA sequence coding a transcription controlling region contained in the chromosomal gene of the serine protease of a human myeloid cell. This sequence is the transcription controlling region being necessary for the gene expression being specific to a human leukocyte or erythrocyte.Type: GrantFiled: February 8, 1995Date of Patent: August 26, 1997Assignee: Toray Industries, Inc.Inventors: Yosuke Aoki, Kiyoshi Okano, Masanobu Naruto, Hirohiko Shimizu, Haruji Nakamura
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Patent number: 5463509Abstract: A disc drive includes a cartridge holder formed of a single piece of sheet metal which cooperates with a slide plate which is similarly formed of a single piece of sheet metal. The sides of inclined guide slots formed in side walls of the slide plate are parallel and serve to guide horizontally projecting flange-like guide members of the cartridge holder. A single piece disc shutter control arm is pivotally mounted in the cartridge holder and motivated by the force which moves the disc cartridge into the disc holder in a manner which opens the disc cartridge shutter. The chuck yoke of the turntable is provided with an inertia increasing annular member. A head is mounted on a pivotal head arm which is operatively connected with the cartridge holder in a manner to be pivoted up and down therewith.Type: GrantFiled: July 20, 1994Date of Patent: October 31, 1995Assignee: Sony CorporationInventors: Yuji Suzuki, Hirohiko Shimizu, Hiroyuki Suzuki, Kiyoaki Tsuji