Patents by Inventor Hirohisa Okuyama
Hirohisa Okuyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8114434Abstract: The invention provides an analgesic anti-inflammatory patch of a hydrophobic type for topical application containing, in a Pressure Sensitive Adhesive(PSA), diclofenac sodium, pyrrolidone or a derivative thereof, a polyhydric alcohol fatty acid ester, and an organic acid. The patch exerts the following effects: (1) diclofenac sodium is effectively and continuously released from a Pressure Sensitive Adhesive(PSA) and percutaneously absorbed, thereby attaining sustained, excellent pharmaceutical and pharmacological effects; (2) the patch per se has high tackiness and safety; and (3) diclofenac sodium remains stable in the Pressure Sensitive Adhesive(PSA).Type: GrantFiled: November 9, 2009Date of Patent: February 14, 2012Assignees: Tokuhon Corporation, SSP Co., Ltd., Dojin Iyaku Kako Co., Ltd.Inventors: Yasuhiko Sasaki, Yukihiro Matsumura, Masaru Yamazaki, Hiroshi Arai, Shogo Kawabata, Masaaki Saito, Hirohisa Okuyama, Makoto Suzuki
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Publication number: 20100055160Abstract: The invention provides an analgesic anti-inflammatory patch of a hydrophobic type for topical application containing, in a Pressure Sensitive Adhesive(PSA), diclofenac sodium, pyrrolidone or a derivative thereof, a polyhydric alcohol fatty acid ester, and an organic acid. The patch exerts the following effects: (1) diclofenac sodium is effectively and continuously released from a Pressure Sensitive Adhesive(PSA) and percutaneously absorbed, thereby attaining sustained, excellent pharmaceutical and pharmacological effects; (2) the patch per se has high tackiness and safety; and (3) diclofenac sodium remains stable in the Pressure Sensitive Adhesive(PSA).Type: ApplicationFiled: November 9, 2009Publication date: March 4, 2010Applicants: TOKUHON CORPORATION, SSP CO., LTD.Inventors: Yasuhiko Sasaki, Yukihiro Matsumura, Masaru Yamazaki, Hiroshi Arai, Shogo Kawabata, Masaaki Saito, Hirohisa Okuyama, Makoto Suzuki
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Publication number: 20100047325Abstract: The invention provides an analgesic anti-inflammatory patch of a hydrophobic type for topical application containing, in a Pressure Sensitive Adhesive(PSA), diclofenac sodium, pyrrolidone or a derivative thereof, a polyhydric alcohol fatty acid ester, and an organic acid. The patch exerts the following effects: (1) diclofenac sodium is effectively and continuously released from a Pressure Sensitive Adhesive(PSA) and percutaneously absorbed, thereby attaining sustained, excellent pharmaceutical and pharmacological effects; (2) the patch per se has high tackiness and safety; and (3) diclofenac sodium remains stable in the Pressure Sensitive Adhesive(PSA).Type: ApplicationFiled: November 9, 2009Publication date: February 25, 2010Applicants: TOKUHON CORPORATION, SSP CO., LTD.Inventors: Yasuhiko SASAKI, Yukihiro Matsumura, Masaru Yamazaki, Hiroshi Arai, Shogo Kawabata, Masaaki Saito, Hirohisa Okuyama, Makoto Suzuki
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Patent number: 7651700Abstract: The invention provides an analgesic anti-inflammatory patch of a hydrophobic type for topical application containing, in a Pressure Sensitive Adhesive (PSA), diclofenac sodium, pyrrolidone or a derivative thereof, a polyhydric alcohol fatty acid ester, and an organic acid. The patch exerts the following effects: (1) diclofenac sodium is effectively and continuously released from a Pressure Sensitive Adhesive (PSA) and percutaneously absorbed, thereby attaining sustained, excellent pharmaceutical and pharmacological effects; (2) the patch per se has high tackiness and safety; and (3) diclofenac sodium remains stable in the Pressure Sensitive Adhesive (PSA).Type: GrantFiled: May 22, 2002Date of Patent: January 26, 2010Assignees: Tokuhon Corporation, SSP Co., Ltd., Dojin Iyaku-Kako Co., Ltd.Inventors: Yasuhiko Sasaki, Yukihiro Matsumura, Masaru Yamazaki, Hiroshi Arai, Shogo Kawabata, Masaaki Saito, Hirohisa Okuyama, Makoto Suzuki
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Publication number: 20030175331Abstract: The invention provides an analgesic anti-inflammatory patch of a hydrophobic type for topical application containing, in a Pressure Sensitive Adhesive (PSA), diclofenac sodium, pyrrolidone or a derivative thereof, a polyhydric alcohol fatty acid ester, and an organic acid.Type: ApplicationFiled: January 23, 2003Publication date: September 18, 2003Inventors: Yasuhiko Sasaki, Yukihiro Matsumura, Masaru Yamazaki, Hiroshi Arai, Shogo Kawabata, Masaaki Saito, Hirohisa Okuyama, Makoto Suzuki
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Patent number: 6207184Abstract: A hydrophilic adhesive mass contains 0.05 to 10 wt. % of a copolymer of an aminoalkyl (meth)acrylate and an alkyl (meth)acrylate. This hydrophilic adhesive mass is excellent in adhesiveness, and especially when combined with a pharmacologically active ingredient, is suitable for use in providing hydrophilic plasters.Type: GrantFiled: June 11, 1999Date of Patent: March 27, 2001Assignee: SSP Co., Ltd.Inventors: Yasuo Ikeda, Hirohisa Okuyama, Kenji Ishigaki, Shuichi Kasai, Katsumi Imamori
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Patent number: 5676970Abstract: An anti-inflammatory analgesic plaster carries thereon a base which comprises piroxicam and a polyoxyethylene nonionic surfactant having 5-15 moles of added ethylene oxide.Type: GrantFiled: October 11, 1995Date of Patent: October 14, 1997Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hirohisa Okuyama, Yasuo Ikeda, Shigenori Otsuka, Shuichi Kasai, Akira Iwasa
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Patent number: 5636632Abstract: A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultra sound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.Type: GrantFiled: March 9, 1994Date of Patent: June 10, 1997Assignees: Cygnus, Inc., The Regents of the University of CaliforniaInventors: Durairaj Bommannan, Hirohisa Okuyama, Richard H. Guy, Paul Stauffer, Gordon L. Flynn
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Patent number: 5496819Abstract: An antiphlogistic-analgesic plaster comprising piroxicam and triacetin and/or triethyl citrate.The antiphlogistic-analgesic plaster of the invention is excellent in percutaneous absorption of piroxicam and hence has an excellent antiphlogistic and analgesic effect.Type: GrantFiled: May 3, 1994Date of Patent: March 5, 1996Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hirohisa Okuyama, Yasuo Ikeda, Shigenori Ohtsuka, Shuichi Kasai, Akira Iwasa
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Patent number: 5323769Abstract: A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.Type: GrantFiled: August 2, 1993Date of Patent: June 28, 1994Assignees: Cygnus Therapeutic Systems, The Regents of the University of CaliforniaInventors: Durairaj Bommannan, Hirohisa Okuyama, Richard H. Guy, Paul Stauffer, Gordon L. Flynn
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Patent number: 5275825Abstract: Compressed molded preparations are disclosed. In the preparation coated granules of a pharmaceutical composition are compressed and molded together with non-coated component(s) containing 10% or more by weight of non-swelling polymers. According to the preparation there is little breakdown of the coating of coated granules at the time of compressing and molding, and the rate of disintegration, and in turn, the release rate of the pharmaceutical component, can be freely controlled or modulated.Type: GrantFiled: September 12, 1991Date of Patent: January 4, 1994Assignee: SS Pharmaceutical Co., Ltd.Inventors: Minoru Okada, Toshiaki Horie, Hirohisa Okuyama, Syuichi Kasai, Akira Iwasa
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Patent number: 5231975Abstract: A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.Type: GrantFiled: March 2, 1992Date of Patent: August 3, 1993Assignees: Cygnus Therapeutic Systems, Regents of the University of CaliforniaInventors: Durairaj Bommannan, Hirohisa Okuyama, Richard H. Guy, Paul Stauffer, Gordon L. Flynn
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Patent number: 5208035Abstract: A diclofenac sodium plaster has a backing material and a paste spread on the backing material. The paste is composed of diclofenac sodium, a penetration enhancer composed of 1-menthol and propylene glycol, and a hydrophilic base composed principally of a water-soluble polymer.Type: GrantFiled: December 3, 1991Date of Patent: May 4, 1993Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hirohisa Okuyama, Yasuo Ikeda, Shigenori Otsuka, Shuichi Kasai, Akira Iwasa
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Patent number: 5186943Abstract: Compressed-molded preparations are disclosed. In the preparation coated granules of a pharmaceutical composition are compressed and molded together with non-coated component(s) containing 10% or more by weight of non-swelling polymers. According to the preparation there is little breakdown of the coating of coated granules at the time of compressing and molding, and the rate of disintegration, and in turn, the release rate of the pharmaceutical component, can be freely controlled or modulated.Type: GrantFiled: January 3, 1989Date of Patent: February 16, 1993Assignee: SS Pharmaceutical Co., Ltd.Inventors: Minoru Okada, Toshiaki Horie, Hirohisa Okuyama, Syuichi Kasai, Akira Iwasa
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Patent number: 5115805Abstract: A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.Type: GrantFiled: February 23, 1990Date of Patent: May 26, 1992Assignees: Cygnus Therapeutic Systems, The Regents of the University of CaliforniaInventors: Durairaj Bommannan, Hirohisa Okuyama, Richard H. Guy, Paul Stauffer, Gordon L. Flynn