Abstract: In a fuel supply control method including determining a cylinder at a suction stroke in a multiple cylinder internal combustion engine at each generation of a first predetermined crank angle position signal and injecting/supplying into a cylinder at a suction stroke a first amount at fuel which is computed by a first technique based on a sucked amount of air, A, and number of engine rotations, N, representing an engine load, a method comprises determining a cylinder at a suction stroke for asynchronous injection at each generation of a second crank angle position signal which is nearer to a top dead center of each cylinder than the first predetermined crank angle position signal; detecting a throttle valve opening for each predetermined time Ts and computing a throttle value opening variation .DELTA. .circleincircle.H ; and injecting/supplying, upon determining the variation .DELTA. .circleincircle.H as being greater than a predetermined value, a second amount of fuel corresponding to the variation .DELTA. .