Patents by Inventor Hirokazu Arimoto

Hirokazu Arimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Degradation agent using autophagic mechanism of damaged mitochondria
    Patent number: 11512084
    Abstract: Provided is a degrader for injured mitochondria based on an autophagy mechanism, the degrader including a compound or a salt thereof, the compound containing a ligand capable of binding to or accumulating in mitochondria and a substituent represented by the following general formula (1): where R1, R2, and R3 are identical to or different from each other, and each represent a hydrogen atom or the like.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: November 29, 2022
    Assignee: TOHOKU UNIVERSITY
    Inventors: Hirokazu Arimoto, Kaori Itto, Daiki Takahashi, Jun Moriyama
  • DEGRADATION AGENT USING AUTOPHAGIC MECHANISM OF DAMAGED MITOCHONDRIA
    Publication number: 20200223848
    Abstract: Provided is a degrader for injured mitochondria based on an autophagy mechanism, the degrader including a compound or a salt thereof, the compound containing a ligand capable of binding to or accumulating in mitochondria and a substituent represented by the following general formula (1): where R1, R2, and R3 are identical to or different from each other, and each represent a hydrogen atom or the like.
    Type: Application
    Filed: July 9, 2018
    Publication date: July 16, 2020
    Applicant: TOHOKU UNIVERSITY
    Inventors: Hirokazu ARIMOTO, Kaori ITTO, Daiki TAKAHASHI, Jun MORIYAMA
  • HETEROCYCLIC COMPOUND
    Publication number: 20200163970
    Abstract: Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce autophagy of an intracellular molecule are linked via a linker without loss of the activity of the ligand and the structure.
    Type: Application
    Filed: February 2, 2018
    Publication date: May 28, 2020
    Inventors: Hirokazu ARIMOTO, Kaori ITTO, Daiki TAKAHASHI, Nobuo CHO, Hiroshi NARA, Kenichiro SHIMOKAWA, Taiichi OHRA, Shigekazu SASAKI, Naoki ISHII
  • Glycopeptide antibiotic monomer derivatives
    Patent number: 8778874
    Abstract: Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—RA [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and RA represents, e.g., the formula —X1—Ar1—X2—Y—X3—Ar2 (wherein X1, X2, and X3 each represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of —N?, ?N—, —NR1—, —O—, etc.; Y represents —NR2CO— or —CONR2— (wherein R2 represents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.
    Type: Grant
    Filed: November 24, 2005
    Date of Patent: July 15, 2014
    Assignees: National University Corporation Nagoya University, Shionogi & Co., Ltd.
    Inventors: Hirokazu Arimoto, Jun Lu, Yoshinori Yamano, Tatsuro Yasukata, Osamu Yoshida, Tsutomu Iwaki, Yutaka Yoshida, Issei Kato, Kenji Morimoto, Kayo Yasoshima
  • Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
    Patent number: 7723536
    Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: May 25, 2010
    Assignee: The Trustees Of The University of Pennsylvania
    Inventors: Amos B. Smith, III, Thomas J. Beauchamp, Matthew J. LaMarche, Yuping Qiu, Michael D. Kaufman, Hirokazu Arimoto, David R. Jones, Kaoru Kobayashi
  • Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
    Publication number: 20090187031
    Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
    Type: Application
    Filed: February 28, 2008
    Publication date: July 23, 2009
    Applicant: The Trustees of The University of Pennsylvania
    Inventors: Amos B. Smith, III, Thomas J. Beauchamp, Matthew J. LaMarche, Yuping Qiu, Michael D. Kaufman, Hirokazu Arimoto, David R. Jones, Kaoru Kobayashi
  • Glycopeptide Antibiotic Monomer Derivatives
    Publication number: 20080097078
    Abstract: Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—RA [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and RA represents, e.g., the formula —X1—Ar1—X2—Y—X3—Ar2 (wherein X1, X2, and X3 each represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of —N?, ?N—, —NR1—, —O—, etc.; Y represents —NR2CO— or —CONR2— (wherein R2 represents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.
    Type: Application
    Filed: November 24, 2005
    Publication date: April 24, 2008
    Inventors: Hirokazu Arimoto, Jun Lu, Yoshinori Yamano, Tatsuro Yasukata, Osamu Yoshida, Tsutomu Iwaki, Yutaka Yoshida, Issei Kato, Kenji Morimoto, Kayo Yasoshima
  • Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
    Publication number: 20050065353
    Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
    Type: Application
    Filed: February 13, 2004
    Publication date: March 24, 2005
    Inventors: Amos Smith, Yuping Qin, Michael Kaufman, Hirokazu Arimoto, David Jones, Kaoru Kobayashi, Thomas Beauchamp
  • Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
    Patent number: 6242616
    Abstract: Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: June 5, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Amos B. Smith, III, Thomas J. Beauchamp, Matthew J. LaMarche, Hirokazu Arimoto
  • Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
    Patent number: 6096904
    Abstract: Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: August 1, 2000
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Amos B. Smith, III, Yuping Qiu, Michael Kaufman, Hirokazu Arimoto, David R. Jones, Kaoru Kobayashi, Thomas J. Beauchamp