Abstract: An embeddable and replenishable controlled drug release device which achieves drug delivery in which the drug release rate can be controlled is provided. The device can be replenished with a drug using a syringe and a needle when implanted in the body. The device has a capsule structure and includes (i) a controlled drug release part for controlled-release of a drug from the device, (ii) a drug storage part for keeping the drug and (iii) a drug introduction part for introducing the drug into the drug storage part. The controlled drug release part has a controlled-release face having a pore, and a hydrogel. The drug storage part is adjacent to the controlled drug release part, and releases the drug kept therein from the pore, and the drug is introduced into the drug storage part through the drug introduction part using a syringe and a needle.

Abstract: Provided are a coating composition containing a silicon atom-containing resin and an anti-sagging agent, a coating film formed from the same, an in-water structure and a ship including the coating film. In the coating composition, the silicon atom-containing resin includes a constituent unit (A) derived from a monomer (a) having at least one kind of silicon atom-containing group selected from the group consisting of groups represented by the formula (I), the formula (II), the formula (III), and the formula (IV), the monomer (a) has a molecular weight of greater than or equal to 400 and less than or equal to 2500, and the content of the anti-sagging agent is greater than or equal to 0.7 parts by mass and less than or equal to 3.6 parts by mass with respect to 100 parts by mass of the silicon atom-containing resin.

Abstract: Provided are a coating composition containing a silicon atom-containing resin and an anti-sagging agent, a coating film formed from the same, an in-water structure and a ship including the coating film. In the coating composition, the silicon atom-containing resin includes a constituent unit (A) derived from a monomer (a) having at least one kind of silicon atom-containing group selected from the group consisting of groups represented by the formula (I), the formula (II), the formula (III), and the formula (IV), the monomer (a) has a molecular weight of greater than or equal to 400 and less than or equal to 2500, and the content of the anti-sagging agent is greater than or equal to 0.7 parts by mass and less than or equal to 3.6 parts by mass with respect to 100 parts by mass of the silicon atom-containing resin.

Abstract: A method for forming a dry coating film on a surface of an object to be coated including the steps of: setting a dry coating film thickness T not smaller than 300 ?m; formulating or preparing a colored paint containing a binder resin and a color pigment and satisfying conditions that (a) a scaly pigment having a prescribed shape is further contained, (b) a content of the scaly pigment is from 5 to 45 volume % in components forming the coating film, (c) a coating film having the thickness T hides the surface, and (d) a color difference between the coating film having the thickness T and a coating film having a thickness of 0.7 T is not smaller than 2.0; coating the surface with the colored paint until the surface is hidden; and drying the coating film, as well as a paint used therefor are provided.

Abstract: Provided are a coating composition containing a silicon atom-containing resin and a defoaming agent, a coating film formed from the same, an in-water structure and a ship having the coating film. In the coating composition, the silicon atom-containing resin includes a constituent unit (A) derived from a monomer (a) having at least one kind of silicon atom-containing group selected from the group consisting of groups represented by the formula (I), the formula (II), the formula (III), and the formula (IV), the monomer (a) has a molecular weight of greater than or equal to 400 and less than or equal to 2500, and the content of the defoaming agent is greater than or equal to 0.7 parts by mass and less than or equal to 24 parts by mass with respect to 100 parts by mass of the silicon atom-containing resin.

Abstract: A capsule device, which can induce vascular bed formation and formation of a space for cell transplantation in subcutaneous tissue in which the device is implanted, is provided. A sustained drug release capsule device, which is to be subcutaneously implanted for subcutaneous sustained release of an angiogenesis-inducing factor as well as formation of a vascular bed as a basis for cell transplantation and a space for cell transplantation in cell therapy, the capsule being made of a material which is not soluble in a biological body and does not adhere to a biological body, and having micropores for sustained release of the angiogenesis-inducing factor.

Abstract: Provided is a novel method of manufacturing a cell-nanoscale thin film composite in which the cell-nanoscale thin film composite can be peeled from a substrate at a controlled timing. The method of manufacturing a cell-nanoscale thin film composite comprises culturing a cell in a cell culture base material in which a nanoscale thin film is provided on an electrode substrate with a self-assembled monolayer interposed therebetween, and reductively desorbing the self-assembled monolayer from the electrode substrate by applying an electric potential to the electrode substrate at a desired timing, so that the cell-nanoscale thin film composite is released.

Abstract: A method for forming a dry coating film on a surface of an object to be coated including the steps of: setting a dry coating film thickness T not smaller than 300 ?m; formulating or preparing a colored paint containing a binder resin and a color pigment and satisfying conditions that (a) a scaly pigment having a prescribed shape is further contained, (b) a content of the scaly pigment is from 5 to 45 volume % in components forming the coating film, (c) a coating film having the thickness T hides the surface, and (d) a color difference between the coating film having the thickness T and a coating film having a thickness of 0.7 T is not smaller than 2.0; coating the surface with the colored paint until the surface is hidden; and drying the coating film, as well as a paint used therefor are provided.

Abstract: A drug delivery system for delivering a drug at a sustained constant rate for a long period, which can be transplanted into an affected part safely and in a simple manner and can deliver a drug to the affected part for a long period. A sustained drug delivery system in which an implant is implanted into a body, wherein the implant is a PEG capsule comprising a box-shaped PEG and a porous PEG sheet.

Abstract: Disclosed is a drug delivery system for delivering a drug at a sustained constant rate for a long period, which can be transplanted into an affected part safely and in a simple manner and can deliver a drug to the affected part for a long period. Specifically disclosed is a sustained drug delivery system in which an implant is implanted into a body, wherein the implant is a PEG capsule comprising a box-shaped PEG and a porous PEG sheet.

Abstract: A drug delivery system for delivering a drug at a sustained constant rate for a long period, which can be transplanted into an affected part safely and in a simple manner and can deliver a drug to the affected part for a long period. A sustained drug delivery system in which an implant is implanted into a body, wherein the implant is a PEG capsule comprising a box-shaped PEG and a porous PEG sheet.

Abstract: The invention provides a method for evaluating a corneal disorder quantitatively and is applicable to living eyes. In particular, the invention provides a method for measuring a corneal transepithelial electric resistance, which method comprises: (1) a step of placing a first electrode on the cornea and a second electrode on the conjunctiva; and (2) a step of flowing an electric current between the first electrode and the second electrode to measure the electric resistance. The invention also provides a device for measuring a corneal transepithelial electric resistance value.

Abstract: Disclosed is a drug delivery system for delivering a drug at a sustained constant rate for a long period, which can be transplanted into an affected part safely and in a simple manner and can deliver a drug to the affected part for a long period. Specifically disclosed is a sustained drug delivery system in which an implant is implanted into a body, wherein the implant is a PEG capsule comprising a box-shaped PEG and a porous PEG sheet.

Abstract: The invention provides a method for evaluating a corneal disorder quantitatively and is applicable to living eyes. In particular, the invention provides a method for measuring a corneal transepithelial electric resistance, which method comprises: (1) a step of placing a first electrode on the cornea and a second electrode on the conjunctiva; and (2) a step of flowing an electric current between the first electrode and the second electrode to measure the electric resistance. The invention also provides a device for measuring a corneal transepithelial electric resistance value.

Abstract: It is intended to provide a novel method of immobilizing a protein and a protein chip, by which the protein can be immobilized at a high reproducibility while preventing the protein from inactivation without resort to a large-scaled apparatus and the protein can be immobilized even in a microchannel. Further, by using a cell adhesive protein as the protein to be immobilized, it is also possible to use a cell as a target and to provide a method of immobilizing a cell and a cell chip, by which a cell can be immobilized in an arbitrary region on a substrate.

Abstract: A reflector is disclosed which enables bright image display with a wide angle of view and can be efficiently fabricated by a a simplified process. The reflector includes a resin layer having at its surface microscopic projections and depressions and formed by application of a coating composition containing a binder resin and crosslinked resin particles.