Abstract: The purpose of the present invention is to provide an anti-CKAP4 monoclonal antibody that inhibits the binding of DKK1 and CKAP4 and exhibits an exceptional antitumor effect. Provided is an anti-CKAP4 monoclonal antibody that recognizes at least part of the 451-455 region, at least part of the 481-485 region, at least part of the 502-510 region, at least part of the 503-524 region and at least part of the 585-590 region, or at least part of the 585-592 region of the amino acid sequence (amino acid sequence of CKAP4) represented by SEQ ID NO:1 as an epitope, the anti-CKAP4 monoclonal antibody effectively inhibiting the binding of DKK1 and CKAP4, the activation of AKT of S2-CP8 cells, and the proliferative ability of S2-CP8 cells or the migratory ability of S2-CP8 cells, and exhibiting an exceptional antitumor effect.

Abstract: The purpose of the present invention is to provide an anti-CKAP4 monoclonal antibody that inhibits the binding of DKK1 and CKAP4 and exhibits an exceptional antitumor effect. Provided is an anti-CKAP4 monoclonal antibody that recognizes at least part of the 451-455 region, at least part of the 481-485 region, at least part of the 502-510 region, at least part of the 503-524 region and at least part of the 585-590 region, or at least part of the 585-592 region of the amino acid sequence (amino acid sequence of CKAP4) represented by SEQ ID NO:1 as an epitope, the anti-CKAP4 monoclonal antibody effectively inhibiting the binding of DKK1 and CKAP4, the activation of AKT of S2-CP8 cells, and the proliferative ability of S2-CP8 cells or the migratory ability of S2-CP8 cells, and exhibiting an exceptional antitumor effect.

Abstract: Disclosed is to identify a target molecule that is involved in Dkk1-induced hyperproliferation of tumor cells to provide a novel antitumor agent. Cytoskeleton-associated protein 4 (CKAP4) specifically regulates the hyperproliferation effects that are induced by dickkopf-related protein 1 (Dkk1), and proliferation of tumor cells can be suppressed by inhibiting expression or function of CKAP4 in the tumor cells.

Abstract: Disclosed is to identify a target molecule that is involved in Dkk1-induced hyperproliferation of tumor cells to provide a novel antitumor agent. Cytoskeleton-associated protein 4 (CKAP4) specifically regulates the hyperproliferation effects that are induced by dickkopf-related protein 1 (Dkk1), and proliferation of tumor cells can be suppressed by inhibiting expression or function of CKAP4 in the tumor cells.

Abstract: A heat sink fan comprises a heat sink (2) including a base member (21) and a plurality of thin heat radiating fins (22) fixed thereto, and a fan case (1) for supporting an axial flow fan (18) that induces air flow for cooling the heat sink (2). The fan case (1) includes an upper wall portion (11), at least one pair of engaging portions (12) depending from side edges of the upper wall portion (11), and a protruding portion (13) formed at the substantial middle portion of both end portions in the longitudinal direction of the upper wall portion (11). A thickness of one or more heat radiating fins (2) facing to the protruding portion (13) is larger than a thickness of other heat radiating fins.

Abstract: A static electricity removing tool for a footwear bottom includes a basal plate having in its inner face an attaching layer for attaching to a ground contacting face of a footwear bottom, a static electricity removing sheet in which a corona discharge is made of an electricity removing material, and a concave portion deeper than a thickness of the static electricity removing sheet, formed in a ground contacting face of the basal plate. Furthermore, a step difference more concave than the ground contacting face of the basal plate is formed in an outer face of the static electricity removing sheet by attaching the static electricity removing sheet to a bottom face of the concave portion by bonding.

Abstract: A heat sink fan comprises a heat sink (2) including a base member (21) and a plurality of thin heat radiating fins (22) fixed thereto, and a fan case (1) for supporting an axial flow fan (18) that induces air flow for cooling the heat sink (2). The fan case (1) includes an upper wall portion (11), at least one pair of engaging portions (12) depending from side edges of the upper wall portion (11), and a protruding portion (13) formed at the substantial middle portion of both end portions in the longitudinal direction of the upper wall portion (11). A thickness of one or more heat radiating fins (2) facing to the protruding portion (13) is larger than a thickness of other heat radiating fins.

Abstract: A magnetic recording apparatus for electrocardiographs wherein an input signal is converted into a digital signal, such digital signal is accumulated and intermittently recorded, thereby enabling electric power consumption to be reduced and efficiency of use to be improved. Parallel memories are used to store the digital signal at a first rate and the digital signal is read from the memories at a second rate higher than the first rate.

Abstract: When both main surface sides of a substrate doped with an impurity at a lower concentraiton are subjected to diffusion to form a higher concentrated impurity layer on the surfaces, about a half of the thickness of the substrate is removed to expose a layer doped with the impurity at the lower concentration on one surface of the substrate. Then the exposed lower concentrated impurity layer is polished to provide the substrate for semiconductor device comprising double layers composed of higher and lower concentrated impurities.

Abstract: An apparatus for inspecting glass bottles generally comprises an operation table, an annular conveyor passage onto which glass bottles to be inspected are conveyed one-by-one and on which the bottles are moved slidably, and a turn table coaxially disposed inside the annular conveyor passage. A plurality of guide members are circumferentially mounted on the peripheral surface of the turn table, and a plurality of bottle inspecting stations are disposed circumferentially and spaced equally therearound. The inspecting stations include a down sealing surface measuring station for measuring the down sealing surface of the lip portion of each bottle, an outer diameter and perpendicularly measuring station for measuring outer diameters of the various portions of each bottle and an inner diameter measuring station for measuring the inner diameter of the lip opening. The bottles inspected or measured are conveyed out of the conveying passage and selectively divided into defective bottles and satisfactory bottles.