Patents by Inventor Hirokazu Tamamura
Hirokazu Tamamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220409594Abstract: CD4 mimic compounds having improved efficacy for anti-HIV treatment and more improved pharmacokinetics are provided. The compounds are represented by formula (I): wherein R1 is C2H4(OC2H4)n—OCH3 or CmH2m+1; R2 is O or NH; n is 3 to 25; and m is 4 to 22, or a salt thereof. HIV infection inhibitor compositions including the compound or a salt thereof as an active ingredient are also disclosed.Type: ApplicationFiled: October 29, 2020Publication date: December 29, 2022Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIONS DISEASESInventors: Shuzo MATSUSHITA, Kazuhisa YOSHIMURA, Hirokazu TAMAMURA, Ami MASUDA, Kohei TAKAHASHI, Takuya KOBAYAKAWA, Shigeyoshi HARADA, Tomoyuki MIURA
-
Patent number: 9066983Abstract: An object of the present invention is to provide an HIV antibody-inducing peptide antigen that is effective in developing an antibody or a vaccine having specificity and binding activity for the three-dimensional structure of a neutralization target, i.e. the mechanism by which HIV invades a target cell; a method for synthesizing the same; a vaccine comprising the peptide antigen, or an HIV three-dimensional structure-recognizing antibody induced by the peptide antigen; and a preventive and/or therapeutic agent for HIV infection comprising the peptide antigen, the vaccine, or the HIV three-dimensional structure-recognizing antibody as an active ingredient.Type: GrantFiled: May 14, 2010Date of Patent: June 30, 2015Assignee: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Hirokazu Tamamura, Toru Nakahara, Wataru Nomura
-
Publication number: 20140056935Abstract: An object of the present invention is to provide a peptide capable of inducing a superior or new neutralizing antibody against HIV, so that HIV infectious disease can be prevented and treated or a greater variety of preventive or therapeutic options can be offered. This object is achieved by using a peptide inducing an HIV's three-dimensional structure-recognizing antibody that recognizes a trimer region of C34, wherein three molecules of a derivative of a helical region C34 peptide at C-terminal region of transmembrane protein gp41 of an HIV particle are ligated via a C3-symmetric template compound having three equivalent linker structures.Type: ApplicationFiled: April 3, 2012Publication date: February 27, 2014Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Hirokazu Tamamura, Tetsuo Narumi, Wataru Nomura, Chie Hashimoto, Jun A. Komano, Kosuke Miyauchi
-
Patent number: 8445291Abstract: Provide is a method for detecting a target substance, which method can visualize the expression of the target substance at any time point while reducing influences on the functions of the target substance, can use fluorescent dyes having various excitation/emission wavelengths, and can achieve easy staining process. Also provided are a tag, a DNA, a vector, a probe and a detection kit suitable for use in the above-described detection method. Specifically, the method for detecting a target substance, comprises the steps of bringing into contact with each other (a) a tag comprising a polypeptide forming an ?-helix structure, the tag bound to the target substance, and (b) a probe comprising a compound bound to a fluorescent dye; and measuring the fluorescence emitted by the fluorescent dye. The binding of the tag ?-helix structure to the probe compound induces a spectral change in the fluorescence emitted by the fluorescent dye.Type: GrantFiled: September 22, 2009Date of Patent: May 21, 2013Assignee: National University Corporation Tokyo Medical and Dental UniversityInventors: Hirokazu Tamamura, Hiroshi Tsutsumi
-
Patent number: 8410059Abstract: Therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt are described. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.Type: GrantFiled: July 8, 2011Date of Patent: April 2, 2013Assignee: Biokine Therapeutics Ltd.Inventors: Nobutaka Fujii, Hirokazu Tamamura, Akira Hori
-
Publication number: 20120052090Abstract: An object of the present invention is to provide an HIV antibody-inducing peptide antigen that can be used without problems for HIV, which is highly prone to mutation, and is effective in developing an antibody or a vaccine having excellent specificity and binding activity even for the three-dimensional structure of a neutralization target, i.e. the mechanism by which HIV invades a target cell; a method for synthesizing the same; a vaccine comprising the peptide antigen, or an HIV three-dimensional structure-recognizing antibody induced by the peptide antigen; and a preventive and/or therapeutic agent for HIV infection comprising the peptide antigen, the vaccine, or the HIV three-dimensional structure-recognizing antibody as an active ingredient.Type: ApplicationFiled: May 14, 2010Publication date: March 1, 2012Applicant: National University Corporation Tokyo Medical and Dental UniversityInventors: Hirokazu Tamamura, Toru Nakahara, Wataru Nomura
-
Publication number: 20110269686Abstract: The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.Type: ApplicationFiled: July 8, 2011Publication date: November 3, 2011Applicant: BIOKINE THERAPEUTICS LTD.Inventors: Nobutaka FUJII, Hirokazu TAMAMURA, Akira HORI
-
Patent number: 8017585Abstract: Peptides, their amides, esters or salts, which have CXCR4 antagonistic action, have therapeutic effects for cancer and chronic rheumatoid arthritis.Type: GrantFiled: July 11, 2008Date of Patent: September 13, 2011Assignee: Biokine Therapeutics Ltd.Inventors: Nobutaka Fujii, Hirokazu Tamamura, Akira Hori
-
Publication number: 20100075434Abstract: Provide is a method for detecting a target substance, which method can visualize the expression of the target substance at any time point while reducing influences on the functions of the target substance, can use fluorescent dyes having various excitation/emission wavelengths, and can achieve easy staining process. Also provided are a tag, a DNA, a vector, a probe and a detection kit suitable for use in the above-described detection method. Specifically, the method for detecting a target substance, comprises the steps of bringing into contact with each other (a) a tag comprising a polypeptide forming an ?-helix structure, the tag bound to the target substance, and (b) a probe comprising a compound bound to a fluorescent dye; and measuring the fluorescence emitted by the fluorescent dye. The binding of the tag ?-helix structure to the probe compound induces a spectral change in the fluorescence emitted by the fluorescent dye.Type: ApplicationFiled: September 22, 2009Publication date: March 25, 2010Inventors: Hirokazu Tamamura, Hiroshi Tsutsumi
-
Publication number: 20090181897Abstract: The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.Type: ApplicationFiled: July 11, 2008Publication date: July 16, 2009Applicant: BIOKINE THERAPEUTICS LTD.Inventors: Nobutaka Fujii, Hirokazu Tamamura, Akira Hori
-
Publication number: 20090036416Abstract: A novel non-peptide CXCR4 antagonist has a low molecular-weight and uses various aromatic compounds, each containing a dipicolylamine-zinc complex. This CXCR4 antagonist finds use, e.g., as an anti-HIV agent, a metastasis inhibitor for a malignant tumor, and a chronic rheumatoid arthritis treatment and/or prevention agent.Type: ApplicationFiled: December 27, 2006Publication date: February 5, 2009Applicant: Kyoto UniversityInventors: Nobutaka Fujii, Itaru Hamachi, Akio Ojida, Hirokazu Tamamura, Hideki Nakashima
-
Patent number: 7423007Abstract: The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.Type: GrantFiled: August 26, 2003Date of Patent: September 9, 2008Assignee: Biokine Therapeutics Ltd.Inventors: Nobutaka Fujii, Hirokazu Tamamura, Akira Hori
-
Publication number: 20060264378Abstract: The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.Type: ApplicationFiled: August 26, 2003Publication date: November 23, 2006Applicant: Takeda Pharmaceutical Company LimitedInventors: Nobutaka Fujii, Hirokazu Tamamura, Akira Hori