Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.

Abstract: Suppressing deterioration in analysis accuracy on an image. A biological specimen detection system includes: a stage (20) capable of supporting a sample including a biological specimen; an observation system (40) that includes an objective lens (44) and observes the sample in a line-shaped visual field that is a part of a visual field through the objective lens; a signal acquisition unit (1) that acquires an image signal obtained from the sample by scanning the observation system in a first direction orthogonal to the line-shaped visual field; and a correction unit (24) that corrects distortion of a captured image based on the image signal on a basis of a positional relationship between an optical axis center of the objective lens and the line-shaped visual field.

Abstract: A data generation method according to an embodiment includes: an imaging step (S10) of capturing, for each of lines for scanning an imaging target, a plurality of fluorescence images generated by the imaging target for a respective plurality of fluorescence wavelengths and acquiring data of the captured plurality of fluorescence images in arrangement order of the lines and a rearrangement step (S12) of changing the arrangement order of the data of the plurality of fluorescence images acquired in the imaging step from the arrangement order of the lines to arrangement order of for each of the plurality of fluorescence wavelengths.

Abstract: A signal acquisition apparatus includes a light source that irradiates a living tissue with light and a detector that acquires signals from light returned from the living tissue to generate output data on the basis of the signals. The detector includes circuitry that acquires the signals and characteristic data regarding the signals and generates the output data on the basis of the characteristic data. The circuitry is implemented in a single semiconductor chip. Further, the present technology also provides a signal acquisition system including the signal acquisition apparatus and an analysis unit configured to analyze output data output from the image acquisition apparatus.

Abstract: A plurality of images are connected such that a subject is represented appropriately in a region where the plurality of images are overlapped with each other. An image generation system includes: an imaging unit (111) that acquires a plurality of partial images by imaging a plurality of regions overlapping with each other; and a connection unit (1331) that connects, on a basis of connection information obtained with at least one channel from among a plurality of channels constituting the plurality of respective partial images as a reference, a plurality of partial images of other channels from among the plurality of channels constituting the plurality of respective partial images to each other.

Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.

Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.

Abstract: High-speed and high-accuracy focus adjustment is achieved. A microscope system (1) includes: an irradiation unit (18) that emits line illumination parallel to a first direction; a stage (26) that supports a specimen and is movable in a second direction perpendicular to the first direction; a phase difference acquisition unit (60I) that acquires phase difference information regarding an image of light emitted from the specimen by being irradiated with the line illumination; an objective lens (22) that focuses the line illumination on the specimen; a derivation unit (60E) that derives relative position information between the objective lens and the specimen based on the phase difference information; and a movement control unit (60F) that causes at least one of the objective lens and the stage to move in a third direction vertical to each of the first direction and the second direction based on the relative position information.

Abstract: A microscope system includes: a light source unit that emits linear illumination parallel to a first direction; an objective lens that condenses the linear illumination onto a measurement target region; an acquisition unit that acquires a first optical signal indicating a light intensity value of light emitted from the measurement target region by the linear illumination; and a focus control unit that controls at least one of a relative position or a relative posture of the light source unit and an imaging unit that generates the first optical signal on a basis of a light intensity distribution of the first optical signal.

Abstract: To provide a microscope device capable of efficiently or appropriately acquiring an image of a specific region of a living tissue. The present technology provides a microscope device including: a first imaging element that images a target including a body tissue and acquires image data; and a second imaging element that images the target at a magnification different from a magnification of the first imaging element and acquires image data, in which the first imaging element includes a determination unit that determines a feature related to the target on the basis of the image data, and the second imaging element is controlled on the basis of a result of the determination. Furthermore, the present technology also provides an image acquisition system including the microscope device. Furthermore, the present technology also provides an image acquisition method performed in the microscope device.

Abstract: A measurement apparatus according to an embodiment of the present technology includes a light source, a filling portion, and a detector. The light source emits illumination light. The filling portion includes a first surface portion and a second surface portion which are provided on an optical path of the illumination light and are opposite to each other, the filling portion enabling a cavity between the first and second surface portions to be filled with liquid including a cell. The detector detects an interference fringe of the illumination light passing through the cavity, the interference fringe being caused by the liquid including the cell.

Abstract: A microscope device includes an opening (31) that includes a first slit and a second slit through which a plurality of pieces of light from an observation target resulting from a plurality of pieces of irradiation light emitted to the observation target and having different wavelengths pass, a dispersion element that wavelength-disperses the plurality of pieces of light passing through the opening (31), and an imaging element (32) that receives the plurality of pieces of light wavelength-dispersed by the dispersion element. The imaging element (32) performs light reception so that, as for the plurality of pieces of light wavelength-dispersed, zeroth-order light of light passing through the second slit and first-order light of light passing through the first slit do not overlap with each other.

Abstract: A signal acquisition apparatus includes a light source that irradiates a living tissue with light and a detector that acquires signals from light returned from the living tissue to generate output data on the basis of the signals. The detector includes circuitry that acquires the signals and characteristic data regarding the signals and generates the output data on the basis of the characteristic data. The circuitry is implemented in a single semiconductor chip. Further, the present technology also provides a signal acquisition system including the signal acquisition apparatus and an analysis unit configured to analyze output data output from the image acquisition apparatus.

Abstract: A specimen is analyzed with high accuracy. An information processing device includes an extraction unit (20E) that extracts fluorescence correction information from a bright visual field image of a specimen, and a generation unit (20F) that generates a fluorescence correction image based on fluorescence information of the specimen and the fluorescence correction information.

Abstract: An irradiation unit (14) projects excitation light (LB) having an asymmetric shape with respect to an optical axis (A1, A2). An objective lens (20) concentrates the excitation light (LB) at a measurement-target member (22) including a glass member (22C, 22A) and a measurement-target region (22B). The detection unit (30) includes at least one or more light-receiving units (31) that receive fluorescence emitted from the measurement-target region (22B) in response to the excitation light (LB), and outputs a fluorescence signal indicating intensity values of fluorescence received by the respective light-receiving units (31).

Abstract: A spectroscopic imaging apparatus according to an embodiment of the present technology includes a spectroscopic section, an image sensor, and a control unit. The spectroscopic section disperses incident light for each wavelength. The image sensor is configured to be capable of setting an exposure time or a gain in a unit of a pixel, and detects light of each wavelength dispersed in the spectroscopic section. The control unit is configured to be capable of setting the exposure time or the gain of the image sensor in a unit of a predetermined pixel area.

Abstract: Provided is an information processing apparatus including an image acquisition section (112), an information acquisition section (111), and an analysis section (131). The image acquisition section (112) acquires image information regarding a specimen stained by a fluorescent reagent (30). The information acquisition section (111) acquires information regarding the specimen (11) and information regarding the fluorescent reagent (10). The analysis section (131) separates a first fluorescence signal and a second fluorescence signal from the image information in accordance with the information regarding the specimen and the information regarding the fluorescent reagent.

Abstract: To obtain a more accurate image by improving a utilization efficiency of light energy while at the same time suppressing with a simpler method distortion that may occur in an inline hologram when a plurality of lights having different wavelengths are used, an observation device (1) according to the present disclosure includes a light source part (11) in which a plurality of light emitting diodes (101) having different light emission wavelengths with a length of each light emission point being smaller than 100? (?: light emission wavelength) are arranged such that a separation distance between the adjacent light emitting diodes is equal to or smaller than 100? (?: light emission wavelength); and an image sensor (13) installed so as to be opposed to the light source part with respect to an observation target object.

Abstract: An image display device includes an image formation device and an optical system that brings an image from the image formation device to an eyeball of an observer. 0 (degrees)??2<?1 is satisfied where an image-formation-device first strike point (CP1) is a point where an extended line of an optical axis of the optical system intersects with an image exit surface of the image formation device, an image-formation-device second strike point (CP2) is a point where an extended line of a pupil center line of the eyeball of the observer intersects with the image exit surface of the image formation device, ?1 represents an angle between the extended line of the optical axis of the optical system and a first normal line (NL1), and ?2 represents an angle between the extended line of the pupil center line and a second normal line (NL2).

Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.