Abstract: Provided is a sulfonamide derivative represented by the following general formula (1) and having an ?4 integrin inhibitory effect with high selectivity with a low effect on ?4?1 and a high effect on ?4?7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).

Abstract: Sulfonamide compounds of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent ?4 integrin-inhibitory action.

Abstract: Provided is a sulfonamide derivative represented by the following general formula (1) and having an ?4 integrin inhibitory effect with high selectivity with a low effect on ?4?1 and a high effect on ?4?7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).

Abstract: Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent ?4 integrin-inhibitory action.

Abstract: The present invention provides a pharmaceutical which possesses an excellent inhibitory effect on NHE3 (Na+/H+ exchanger type 3) and effectively improves diseases or conditions of organs in which NHE3 is expressed.

Abstract: The present invention provides a pharmaceutical which possesses an excellent inhibitory effect on NHE3 (Na+/H+ exchanger type 3) and effectively improves diseases or conditions of organs in which NHE3 is expressed.

Abstract: A guide hole 16b is formed in the insulation cap 16 of a starter motor electromagnetic switch, and a coil terminal 30 inserted through the guide hole has one or more projections 30b formed at a location corresponding to the guide hole so that the projections are wedged against an inner surface of the hole, thus preventing any resonant vibrations of the terminal and the attendant severing of its attached lead wire 1a.

Abstract: A starter for an automotive engine wherein the front bracket 9 forming part of the housing of the starter is provided with first and second drainage port 12, 16. An electromagnetic switch a of the starter is situated substantially horizontally, alongside of the motor portion. The first drainage port is formed at the bottom of the switch box portion 10 of the front bracket accommodating the front end portion of the plunger 8a of the electromagnetic switch, to communicate the interior of the switch box portion to the exterior. The second drainage port communicates with to the first drainage port from the interior of the lever box portion 11 which accommodates the fulcrum portion 7a of the lever transmitting the movement of the plunger of the electromagnetic switch to the pinion assembly of the starter axially slidably supported on the output shaft coupled to the rotor shaft of the motor of the starter.

Abstract: An overhang-type starter comprising a ball bearing fixedly fitted in a front bracket; a pinion drive shaft supported by the bearing; and a pinion formed on the shaft at the front end thereof so that the pinion is located in front of the bearing at least when the pinion is moved forward, wherein a water drain hole is provided in the ball bearing support portion of said bracket at the lowermost point of the portion and communicates with the interior of the bracket.