Abstract: A fixed-pattern noise reduction system comprising a receiver, a determination circuit, an image sensor driver, a subtracter and an output circuit is provided. The receiver receives optical pixel signals and artificial black pixel signals. The determination circuit determines whether the signal intensity of the optical pixel signal is less than a threshold. The image sensor driver orders the image sensor to carry out a second capture at least one time after the signal intensity of the optical pixel signal is less than the threshold. The subtracter subtracts noise signals from the optical pixel signals. The noise signals are generated on the basis of the artificial black pixel signal. The output circuit outputs the optical pixel signals that the subtracter subtracts the noise signals from after carrying out the second capture after carrying out the second capture.