Patents by Inventor Hiroki Ishioka

Hiroki Ishioka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazopyridine compounds
    Patent number: 9278968
    Abstract: [Problem] A pharmaceutical composition for treating or preventing various cardiovascular diseases, which have sGC activities based on improvement of cGMP signals, is provided. [Means for Solution] It was found that imidazo[1,2-a]pyridine compounds having a carbamoyl group at the 3-position and a particular cyclic group at the 8-position via a methyleneoxy group, or a salt thereof have sGC activation, and are useful as active ingredients of pharmaceutical compositions for treating or preventing various sGC-related cardiovascular diseases, in particular, peripheral arterial diseases, intermittent claudication, critical limb ischemia, hypertension, and pulmonary hypertension, thereby completing the present invention.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: March 8, 2016
    Assignee: Astellas Pharma Inc.
    Inventors: Toshio Kurosaki, Tsubasa Watanabe, Kazuhiko Ohne, Hiroki Ishioka, Eisuke Nozawa, Takeshi Hanazawa, Shunichiro Hachiya, Hiroshi Shibata, Yuji Koga, Ryo Mizoguchi
  • IMIDAZOPYRIDINE COMPOUNDS
    Publication number: 20150232464
    Abstract: [Problem] A pharmaceutical composition for treating or preventing various cardiovascular diseases, which have sGC activities based on improvement of cGMP signals, is provided. [Means for Solution] It was found that imidazo[1,2-a]pyridine compounds having a carbamoyl group at the 3-position and a particular cyclic group at the 8-position via a methyleneoxy group, or a salt thereof have sGC activation, and are useful as active ingredients of pharmaceutical compositions for treating or preventing various sGC-related cardiovascular diseases, in particular, peripheral arterial diseases, intermittent claudication, critical limb ischemia, hypertension, and pulmonary hypertension, thereby completing the present invention.
    Type: Application
    Filed: November 28, 2013
    Publication date: August 20, 2015
    Applicant: ASTELLAS PHARMA INC.
    Inventors: Toshio Kurosaki, Tsubasa Watanabe, Kazuhiko Ohne, Hiroki Ishioka, Eisuke Nozawa, Takeshi Hanazawa, Shunichiro Hachiya, Hiroshi Shibata, Yuji Koga, Ryo Mizoguchi
  • CONDENSED PYRROLOPYRIDINE DERIVATIVE
    Publication number: 20120034250
    Abstract: [Problem] The present invention provides a condensed pyrrolopyridine derivative which is useful as an active ingredient for a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases caused by undesirable cytokine signal transduction or diseases caused by abnormal cytokine signal transduction. [Means for Solution] The present inventors have extensively studied a compound having a JAK inhibitory action, and as a result, they have found that a condensed pyrrolopyridine derivative which is the compound of the present invention has an excellent JAK inhibitory action, and is therefore useful as an agent for preventing or treating diseases caused by undesirable cytokine signal transduction or diseases caused by abnormal cytokine signal transduction, thereby completing the present invention.
    Type: Application
    Filed: April 13, 2010
    Publication date: February 9, 2012
    Applicant: Astellas Pharma Inc.
    Inventors: Shohei Shirakami, Yutaka Nakajima, Jun Maeda, Hiroaki Tominaga, Hiroaki Yamagishi, Takeshi Hondo, Masamichi Inami, Hiroki Morio, Takayuki Inoue, Tsuyoshi Mizutani, Hiroki Ishioka