Abstract: Antimicrobial peptide provided by present invention is an artificially designed antimicrobial peptide that does not occur naturally, and includes a sequence composed of at least 6 contiguous amino acid residues selected from an amino acid sequence constituting laminin binding site (LBS), or said sequence with one or a plurality of amino acid residue(s) conservatively replaced, and an amino acid sequence that can express antimicrobial activity against at least one kind of bacteria or fungi. It is desirable that the total number of amino acid residues is 100 or less.

Abstract: Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: (R or Q)-(L or F or I)—I—K-(L or F or I or V)-L-Y-Q; and/or, modified sequence composed of said sequence with partial modification.

Abstract: Provided are novel pyridine compounds represented by the following formula (7): wherein R1 and R4 may be the same or different and are each a linear or branched alkyl group having 1 to 4 carbon atoms; R2 and R5 are hydrogen atoms, or may be the same or different and are each a halogen atom, lower alkyl group or lower alkoxy group; R3 is a linear or branched alkyl group having 2 to 12 carbon atoms; R6 is a linear or branched alkyl group having 1 to 18 carbon atoms; and Z is a chlorine atom, bromine atom or iodine atom or an OSO2R7 group in which R7 is a lower alkyl group or a substituted or unsubstituted phenyl group. Also provided is their production process, which can easily provide them at low cost from readily-available pyridine compounds as starting raw materials.

Abstract: The present invention provides an artificially synthesized antimicrobial polypeptide that does not occur in nature and an antimicrobial agent comprising this polypeptide as the main component. This polypeptide contains in its peptide chain one or more types of nuclear localization signal sequences (NLSs) and/or one or more units of sequences prepared by partially modifying the NLS(s). The one or more units of NLSs and/or modified NLSs contain at least 5 amino acid residues in total and amount to 30% or more of the total amino acid residues constituting the peptide chain.

Abstract: Provided are novel pyridine compounds represented by the following formula (7): wherein R1 and R4 may be the same or different and are each a linear or branched alkyl group having 1 to 4 carbon atoms; R2 and R5 are hydrogen atoms, or may be the same or different and are each a halogen atom, lower alkyl group or lower alkoxy group; R3 is a linear or branched alkyl group having 2 to 12 carbon atoms; R6 is a linear or branched alkyl group having 1 to 18 carbon atoms; and Z is a chlorine atom, bromine atom or iodine atom or an OSO2R7 group in which R7 is a lower alkyl group or a substituted or unsubstituted phenyl group. Also provided is their production process, which can easily provide them at low cost from readily-available pyridine compounds as starting raw materials.

Abstract: An object of the invention is to provide an antimicrobial peptide having an amino acid sequence which is different from a peptide existing and functioning as an antimicrobial peptide in the natural world and is not based on the conventional developmental approach for an antimicrobial peptide-containing antimicrobial agent, and a polynucleotide coding for said peptide. Another object is to provide an antimicrobial agent which contains such an antimicrobial peptide. Namely, an antimicrobial peptide represented by a general formula (1) (Xa)n-S??(1) wherein Xa of the formula (1) is a hydrophilic amino acid residue, n is an integer of from 1 to 6, two or more of the Xa may be the same or different from one another, S is a peptide represented by hydrophobic amino acid part-basic amino acid part-bridge part-basic amino acid part-hydrophobic amino acid part, and amino acid residue of the bridge part is selected from the group consisting of hydrophobic amino acids and neutral amino acids.

Abstract: Antimicrobial peptide provided by present invention is an artificially designed antimicrobial peptide that does not occur naturally, and includes a sequence composed of at least 6 contiguous amino acid residues selected from an amino acid sequence constituting laminin binding site (LBS), or said sequence with one or a plurality of amino acid residue(s) conservatively replaced, and an amino acid sequence that can express antimicrobial activity against at least one kind of bacteria or fungi. It is desirable that the total number of amino acid residues is 100 or less.

Abstract: Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: (R or Q)-(L or F or I)—I—K-(L or F or I or V)-L-Y-Q; and/or, modified sequence composed of said sequence with partial modification.

Abstract: An object of the invention is to provide an antimicrobial peptide having an amino acid sequence which is different from a peptide existing and functioning as an antimicrobial peptide in the natural world and is not based on the conventional developmental approach for an antimicrobial peptide-containing antimicrobial agent, and a polynucleotide coding for said peptide. Another object is to provide an antimicrobial agent which contains such an antimicrobial peptide. Namely, an antimicrobial peptide represented by a general formula (1) (Xa)n-S??(1) wherein Xa of the formula (1) is a hydrophilic amino acid residue, n is an integer of from 1 to 6, two or more of the Xa may be the same or different from one another, S is a peptide represented by hydrophobic amino acid part-basic amino acid part-bridge part-basic amino acid part-hydrophobic amino acid part, and amino acid residue of the bridge part is selected from the group consisting of hydrophobic amino acids and neutral amino acids.

Abstract: The novel quaternary ammonium salt according to the invention has two quaternary ammonium groups connected to a benzene ring, wherein two C4-12 alkyl groups and one C1-2 alkyl group are connected per one nitrogen atom constituting the quaternary ammonium. The compound is used as an antimicrobial agent, exhibits a high safety to human as compared with known antimicrobial agents, exerts an excellent sterilizing effect itself and exhibits a wide sterilizing spectrum. In particular, the compound is used as a presevative for eye drop.

Abstract: It is disclosed that an antibacterial acrylonitrile fiber having a photocatalytic activity in which an acrylonitrile fiber containing an antibacterially active metal compound is subjected to a heat treatment within a range of pH 1-6.

Abstract: The present invention provides an antimicrobial detergent composition containing, as an antimicrobial agent, a bis-quaternary ammonium compound of the general formula wherein the two R1 may be the same or different and each represents an alkyl group of 1 to 18 carbon atoms or an alkenyl group of 3 to 18 carbon atoms; the two R2 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, an alkyl group of 1 to 6 carbon atoms or an alkoxy group of 1 to 3 carbon atoms; R3 represents an alkylene group of 1 to 18 carbon atoms, an alkenylene group of 3 to 18 carbon atoms or a phenylene or xylylene group which may optionally be substituted by an alkyl group of 1 to 18 carbon atoms, an alkoxy group of 1 to 6 carbon atoms or an alkoxycarbonyl group of 2 to 6 carbon atoms; Y1 represents —NHCO—, —CONH—, —NHCS—, —COO—, —COS—, —O— or —S—; Y2 represents —CONH&md

Abstract: The novel quaternary ammonium salt according to the invention has two quaternary ammonium groups connected to a benzene ring, wherein two C4-12 alkyl groups and one C1-2 alkyl group are connected per one nitrogen atom constituting the quaternary ammonium. The compound is used as an antimicrobial agent, exhibits a high safety to human as compared with known antimicrobial agents, exerts an excellent sterilizing effect itself and exhibits a wide sterilizing spectrum. In particular, the compound is used as a presevative for eye drop.

Abstract: The present invention provides an antibacterial and antifungal resin composition comprising a polymeric resin and an antibacterial bis-pyridinium compound of the general formula wherein the two R1 may be the same or different, and each represent an alkyl group of 1 to 18 carbon atoms or an alkenyl group of 3 to 18 carbon atoms; the two R2 may be the same or different, and each represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, an alkyl group of 1 to 6 carbon atoms, or an alkoxy group of 1 to 3 carbon atoms; R3 represents an alkylene group of 2 to 18 carbon atoms, an alkenylene group of 3 to 18 carbon atoms, or a phenylene or xylylene group which may optionally be substituted by an alkyl group of 1 to 18 carbon atoms, an alkoxy group of 1 to 6 carbon atoms, or an alkoxycarbonyl group of 2 to 6 carbon atoms; Y1 represents —NHCO—, —CONH—, —NHCS—, —COO—, —COS—, —O— or —S—; Y2 represents

Abstract: The present invention provides a polymerizable monomer represented by the general formula (1), polymer thereof, process for preparing the polymer and the use of the polymer ##STR1## wherein R.sup.1 is a hydrogen atom, methyl, chlorine or cyano, R.sup.2 is alkylene having 1 to 4 carbon atoms, R.sup.3 is alkylene having 3 to 10 carbon atoms, R.sup.4 is alkyl having 6 to 18 carbon atoms, R.sup.6 to R.sup.8 are the same or different and are each alkyl or substituted alkyl having 1 to 3 carbon atoms, A is methylene, phenylene, substituted phenylene, --CH.sub.2 O--, --CH.sub.2 CH.sub.2 O--, --CO--, --CO--N(R.sup.9)-- (wherein R.sup.9 is a hydrogen atom or methyl) or vinylene, m is 0 or 1, and X and Y are the same or different, and are each a monovalent anion or form a bivalent anion when taken together.

Abstract: The present invention provides a microbicide which comprises a phosphate represented by the following general formula:M.sub.a.sup.1 A.sub.b M.sub.c.sup.2 (PO.sub.4).sub.d.nH.sub.2 Owherein M.sup.1 represents at least one element selected from the group consisting of silver, copper, zinc, tin, mercury, lead, iron, cobalt, nickel, manganese, arsenic, antimony, bismuth, barium, cadmium and chromium, M.sup.2 represents at least one element selected from tetravelent metal elements, A represents at least one ion selected from the group consisting of hydrogen ion, alkali metal ions, alkaline earth metal ions and ammonium ion, n represents a number which satisfies 0.ltoreq.n.ltoreq.6, a and b each represents a positive number and satisfy la+mb=1 or la+mb=2, and when a and b satisfy la+mb=1, c is 2 and d is 3, and when a and b satisfy la+mb=2, c is 1 and d is 2, where 1 is valence of M.sup.1 and m is valence of A.

Abstract: An antibacterial polymer containing a repeating unit of the formula ##STR1## wherein A, l and n are defined in the specification.

Abstract: An antibacterial polymer containing a repeating unit of the formula ##STR1## wherein A, l and n are defined in the specification.