Abstract: A pneumatic tire includes a tread portion provided with main grooves and land potions. The main grooves include an outboard shoulder main groove, an inboard shoulder main groove and a central main groove disposed therebetween. The land portions include an outboard central land portion and an inboard central land portion. The outboard central land portion is provided with first central sipes with a width of less than 2 mm, and is not provided with any grooves with a width equal to or more than 2 mm. The inboard central land portion is provided with second central sipes with a width of less than 2 mm, and is not provided with any grooves with a width equal to or more than 2 mm. The inboard central land portion is greater than the outboard central land portion in axial width.

Abstract: The present invention provides a novel alkylating agent specifically binding to the genetic mutation site of a driver oncogene. There are provided are a complex formed by binding an alkylating agent to a pyrrole imidazole polyamide specifically binding to the genetic mutation site of a driver oncogene, a driver oncogene mutation-specific alkylating agent comprising the aforementioned complex, and a pharmaceutical composition comprising the aforementioned complex.

Abstract: A pneumatic tire includes a tread portion provided with a first shoulder main groove, a second shoulder main groove and at least one main groove to separate a first crown portion and a second crown portion. The first crown portion is provided with first crown sipes with a width less than 2 mm, but is not provided with any grooves with a width equal to or more than 2 mm. The second crown portion is provided with second crown sipes having a width less than 2 mm, but is not provided with any grooves with a width equal to or more than 2 mm. Each first crown sipe extends from the crown main groove to the first shoulder main groove with a first inclination direction. Each second crown sipe extends from the crown main groove to the second shoulder main groove with the first inclination direction.

Abstract: A cooling-fan-apparatus fan shroud includes: a cover wall that closes a space between a heat exchanger and a circumference of a fan; and a passing permitting frame part that is positioned between the fan and an attachment part to a vehicle at an outer side of the cover wall and that allows free passing of traveling air, wherein a reinforcement rib is provided at an opening of the passing permitting frame part, and at least part of the reinforcement rib is a deflection louver that guides the traveling air to a predetermined direction.

Abstract: A method of separating a target double-stranded nucleic acid molecule from a sample including the target double-stranded nucleic acid molecule and a non-target double-stranded nucleic acid molecule, including (1) mixing the sample, a pyrrole-imidazole-containing polyamide (first PI polyamide) modified with a first linker molecule and capable of specifically binding to a sequence of the target double-stranded nucleic acid molecule, and a carrier a modified with a first ligand capable of specifically binding and/or adsorbing to the first linker molecule such that a mixed solution is produced, (2) forming a complex A by binding the carrier a to the first PI polyamide with which the target double-stranded nucleic acid molecule is bound in the mixed solution, and (3) separating the complex A from the mixed solution.

Abstract: The present invention relates to an oil pump for use in and attached to a device (e.g., chain saw) having an oil-supplied portion requiring an oil supply. An oil pump supplies lubricating oil to a guide groove of a guide bar in such a manner that a plunger having a gear portion meshing with a drive worm provided on a chain saw reciprocally moves in a pump body while rotating. Two guide pins for positioning an oil pump when attaching the oil pump to a chain saw body are provided on an attachment surface of the pump body to the chain saw body. The two guide pins are spaced apart in an axial direction of the plunger, each disposed on a centerline of a transverse cross section of the plunger.

Abstract: A pneumatic tire includes a tread portion provided with main grooves and land potions. The main grooves include an outboard shoulder main groove, an inboard shoulder main groove and a central main groove disposed therebetween. The land portions include an outboard central land portion and an inboard central land portion. The outboard central land portion is provided with first central sipes with a width of less than 2 mm, and is not provided with any grooves with a width equal to or more than 2 mm. The inboard central land portion is provided with second central sipes with a width of less than 2 mm, and is not provided with any grooves with a width equal to or more than 2 mm. The inboard central land portion is greater than the outboard central land portion in axial width.

Abstract: The present invention provides a novel alkylating agent specifically binding to the genetic mutation site of a driver oncogene. There are provided are a complex formed by binding an alkylating agent to a pyrrole imidazole polyamide specifically binding to the genetic mutation site of a driver oncogene, a driver oncogene mutation-specific alkylating agent comprising the aforementioned complex, and a pharmaceutical composition comprising the aforementioned complex.

Abstract: A pneumatic tire includes a tread portion provided with a first shoulder main groove, a second shoulder main groove and at least one main groove to separate a first crown portion and a second crown portion. The first crown portion is provided with first crown sipes with a width less than 2 mm, but is not provided with any grooves with a width equal to or more than 2 mm. The second crown portion is provided with second crown sipes having a width less than 2 mm, but is not provided with any grooves with a width equal to or more than 2 mm. Each first crown sipe extends from the crown main groove to the first shoulder main groove with a first inclination direction. Each second crown sipe extends from the crown main groove to the second shoulder main groove with the first inclination direction.

Abstract: The present invention relates to an oil pump for use in and attached to a device (e.g., chain saw) having an oil-supplied portion requiring an oil supply. An oil pump supplies lubricating oil to a guide groove of a guide bar in such a manner that a plunger having a gear portion meshing with a drive worm provided on a chain saw reciprocally moves in a pump body while rotating. Two guide pins for positioning an oil pump when attaching the oil pump to a chain saw body are provided on an attachment surface of the pump body to the chain saw body. The two guide pins are spaced apart in an axial direction of the plunger, each disposed on a centerline of a transverse cross section of the plunger.

Abstract: An engine includes: a carburetor configured to supply an air-fuel mixture of fuel and air; a crank case defining a crank chamber; a cylinder block which includes: a cylinder bore in which a reciprocable piston is disposed; and an intake port which supplies the air-fuel mixture supplied from the carburetor to the crank chamber; a control valve configured to open and close the intake port; and a controller configured to control the control valve. The controller controls the number of times that the control valve closes the intake port with respect to the number of times that the piston moves up to thereby reduce pressure of the crank chamber.

Abstract: In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.

Abstract: Disclosed is a topical therapeutic agent for ophthalmic diseases, which comprises a compound capable of binding specifically to a DNA sequence. More preferably disclosed is a topical therapeutic agent for ophthalmic diseases, which comprise a pyrrole-imidazole polyamide having a specific structure. The topical therapeutic agent for ophthalmic diseases comprises a pyrrole-imidazole polyamide which can inhibit transforming growth factor-? gene and matrix metalloproteinase 9 gene.

Abstract: The present invention provides a target gene-specific histone modification regulator, which comprises a conjugate between a histone modification regulator and a polyamide capable of recognizing a regulatory region in a target gene. This enables the provision of a target gene-specific histone modification regulator.

Abstract: Disclosed are: an inhibitor of the expression of matrix metalloproteinase-9 gene; a therapeutic agent for a disease associated with matrix metalloproteinase-9; and a carcinostatic agent. Each of the agents comprises a pyrrole-imidazole polyamide having an N-methylpyrrole unit, an N-methylimidazole unit and a ?-aminobutyric acid unit. The pyrrole-imidazole polyamide can be folded at the site of the ?-aminobutyric acid unit to form a U-shaped conformation in a minor groove of a double-stranded domain comprising a part or the whole of a specific nucleotide sequence (SEQ ID NO:2, SEQ ID NO:4) included in a human matrix metalloproteinase-9 gene promoter and a strand complementary to the part or the whole of the specific nucleotide sequence. In the U-shaped conformation, a Py-Im pair, an Im/Py pair and a Py/Py pair in the pyrrole-imidazole polyamide target a C-G base pair, a G-C base pair, and both of an A-T base pair and a T-A base pair in the minor groove, respectively.

Abstract: In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.