Abstract: [Problem] To provide a compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer. [Means for resolution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a quinazoline compound has an excellent degradation-inducing action on a G12D mutant KRAS protein and a G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The quinazoline compound or a salt thereof of the present invention can be used as a therapeutic agent for pancreatic cancer.

Abstract: [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided. [Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a 4-aminoquinazoline compound has an excellent G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The 4-aminoquinazoline compound of the present invention or a salt thereof can be used as a therapeutic agent for pancreatic cancer.

Abstract: An automatic frequency monitoring circuit automatically monitors a frequency of a clock related to an operation of a device to be monitored. In the automatic frequency monitoring circuit, a frequency detecting unit detects, upon detecting a predetermined momentum, the frequencies of a monitoring target clock during a predetermined time for a predetermined number of times and treats as a detection frequency of the monitoring target clock, an average of the frequencies that are detected for the predetermined number of times. A frequency monitoring unit monitors, upon the frequency detecting unit detecting the detection frequency of the monitoring target clock, whether the frequency of the monitoring target clock during the predetermined time is within a predetermined fluctuation range based on the detection frequency.

Abstract: An automatic frequency monitoring circuit automatically monitors a frequency of a clock related to an operation of a device to be monitored. In the automatic frequency monitoring circuit, a frequency detecting unit detects, upon detecting a predetermined momentum, the frequencies of a monitoring target clock during a predetermined time for a predetermined number of times and treats as a detection frequency of the monitoring target clock, an average of the frequencies that are detected for the predetermined number of times. A frequency monitoring unit monitors, upon the frequency detecting unit detecting the detection frequency of the monitoring target clock, whether the frequency of the monitoring target clock during the predetermined time is within a predetermined fluctuation range based on the detection frequency.