Abstract: In an embodiment, an object of the present invention is to provide a double-stranded nucleic acid complex having a novel structure. In an embodiment, the present invention relates to a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein said first nucleic acid strand: (1) is capable of hybridizing to at least a part of a target transcriptional product; (2) has an antisense effect on the target transcriptional product; and (3) is a gapmer comprising a central region, and a 5? wing region and a 3? wing region, said second nucleic acid strand comprises at least one sugar-unmodified central region (first exposed region) consisting of one sugar-unmodified ribonucleoside or two or three contiguous sugar-unmodified ribonucleosides linked by an internucleoside bond, which is or are complementary to a part of said first nucleic acid strand, and said first nucleic acid strand is annealed to said second nucleic acid strand.

Abstract: A pharmaceutical composition includes a cell-free conditioned medium (CM) or extract or concentrate thereof obtained from a mammalian cell culture medium comprising a cultured substantially homogenous cancerous mammalian cell population. At least a portion of the cancerous mammalian cell population is contacted by at least one small molecule cell growth signaling pathway activator before being cultured in the cell culture medium.

Abstract: An indwelling needle having: inner needle that punctures living body; outer needle inserted into living body with inner needle as inner needle penetrates outer needle and punctures living body; main body disposed along axis of inner needle; branch part that branches from main body. Indwelling needle includes: outer needle hub has passage in communication with interior of outer needle; elastic member disposed within outer needle hub, penetrated by inner needle, and flexible solid part that blocks fluid flow to proximal end side of main body when inner body is removed; holder attached to proximal end of elastic member. Elastic member forms at least part of passage that allows communication between interior of outer needle and branch part, has end surface inclined relative to axial direction. Outer needle hub has guide part engaged with elastic member or holder and guides rotation direction of elastic member around axis to certain direction.

Abstract: A surface treatment method is for processing a surface of a substrate. The method includes irradiating a surface having unevenness with a laser beam satisfying all of the three following requirements: a power density in a range with a radius of 25 ?m from a center of a laser beam spot is 1.0×103 to 1.0×105 kW/cm2; a power density of an entire laser beam spot is 0.08 to 0.12 times the power density in the range with the radius of 25 ?m from the center of the laser beam spot; and an action time in the range with the radius of 25 ?m from the center of the laser beam spot is 1.7×10-6 to 1.0×10-5 seconds. The method leaves a certain roughness on the surface of the substrate while removing fine and sharp protrusions on the surface.

Abstract: A volume measurement apparatus comprises: a point group conversion part converting depth information from a depth sensor into point group data; a raw material heap detection part detecting a point group related to a raw material heap from the point group data, using repose angle information; and a raw material heap volume calculation part that calculates a volume of the raw material heap non-occlusion part based on the point group related to the raw material heap; estimates a volume of the raw material heap occlusion part in the raw material heap, using at least the point group related to the raw material heap; and calculates a volume of the raw material heap, which is a sum of the calculated volume of the raw material heap non-occlusion part and the estimated volume of the raw material heap occlusion part.

Abstract: An object detection apparatus comprising: an input part configured to input video data, an extraction part configured to extract image data from the video data, and a determination part configured to determine whether or not the image data includes an object, wherein the determination part is configured to: set a plurality of regions in a learning image data such that the object appearing in the learning image data extracted from a learning video data captured in advance extends over at least the plurality of regions, assign a learning teach label to each of the regions set, and determine whether or not the image data includes the object by using a prediction model generated by utilizing the learning teach label assigned to each of the regions set.

Abstract: A ceramic substrate is irradiated in an atmospheric air with a laser having a power density of 1.0×107-1.0×109 W/cm2 for an action time on an irradiation area of 1.0×10?7-1.0×10?5 s to roughen a surface of the ceramic substrate, as well as to form an oxide layer on a roughened surface. A thermal sprayed coating formed on the ceramic substrate sufficiently adheres to the ceramic substrate via the oxide layer.

Abstract: A method for producing a surface-modified component includes: a process of forming a thermal sprayed coating on a substrate; a process of irradiating a surface of the thermal sprayed coating with a high energy beam so as to cause an entirety of the thermal sprayed coating and a part of the substrate in a thickness direction to melt and then solidify, and thereby forming a densified modified layer; a process of forming a thermal sprayed coating on the modified layer which has been formed in the latest; and a process of irradiating a surface of the thermal sprayed coating with a high energy beam so as to cause an entirety of the thermal sprayed coating and a part of the modified layer which has been formed in the latest in the thickness direction to melt and then solidify, and thereby forming a densified modified layer.

Abstract: An object detection apparatus comprising: an input part configured to input video data, an extraction part configured to extract image data from the video data, and a determination part configured to determine whether or not the image data includes an object, wherein the determination part is configured to: set a plurality of regions in a learning image data such that the object appearing in the learning image data extracted from a learning video data captured in advance extends over at least the plurality of regions, assign a learning teach label to each of the regions set, and determine whether or not the image data includes the object by using a prediction model generated by utilizing the learning teach label assigned to each of the regions set.

Abstract: A method for producing a surface-modified component includes: a process of forming a thermal sprayed coating on a substrate; a process of irradiating a surface of the thermal sprayed coating with a high energy beam so as to cause an entirety of the thermal sprayed coating and a part of the substrate in a thickness direction to melt and then solidify, and thereby forming a densified modified layer; a process of forming a thermal sprayed coating on the modified layer which has been formed in the latest; and a process of irradiating a surface of the thermal sprayed coating with a high energy beam so as to cause an entirety of the thermal sprayed coating and a part of the modified layer which has been formed in the latest in the thickness direction to melt and then solidify, and thereby forming a densified modified layer.

Abstract: A log management apparatus includes a memory configured to store log information and identification information in association with each other, and a processor configured to store, in association with first identification information in the memory, first log information output, before a semaphore returns to an initial value but after the semaphore decreases from the initial value, from a program employing the semaphore, associate the first identification information with information relative to deletion of the log information when the semaphore has returned to the initial value, and perform deletion of the first log information among the log information stored in the memory in accordance with the first identification information associated with the information.

Abstract: An information processing apparatus takes each currently executing job as a candidate job, and when determining that a migration of a candidate job to a migration destination node selected from free nodes, which are not executing any jobs, is expected to expand a continued range of free nodes, specifies the migration as a possible migration. Then, on the basis of the amounts of communication needed to perform individual migrations based on a plurality of possible migrations and the numbers of nodes used for executing candidate jobs to be migrated in the individual possible migrations, the information processing apparatus determines a possible migration to be performed.

Abstract: A log management apparatus includes a memory configured to store log information and identification information in association with each other, and a processor configured to store, in association with first identification information in the memory, first log information output, before a semaphore returns to an initial value but after the semaphore decreases from the initial value, from a program employing the semaphore, associate the first identification information with information relative to deletion of the log information when the semaphore has returned to the initial value, and perform deletion of the first log information among the log information stored in the memory in accordance with the first identification information associated with the information.

Abstract: A ceramic substrate is irradiated in an atmospheric air with a laser having a power density of 1.0×107-1.0×109 W/cm2 for an action time on an irradiation area of 1.0×10?7-1.0×10?5 s to roughen a surface of the ceramic substrate, as well as to form an oxide layer on a roughened surface. A thermal sprayed coating formed on the ceramic substrate sufficiently adheres to the ceramic substrate via the oxide layer.

Abstract: An information processing apparatus takes each currently executing job as a candidate job, and when determining that a migration of a candidate job to a migration destination node selected from free nodes, which are not executing any jobs, is expected to expand a continued range of free nodes, specifies the migration as a possible migration. Then, on the basis of the amounts of communication needed to perform individual migrations based on a plurality of possible migrations and the numbers of nodes used for executing candidate jobs to be migrated in the individual possible migrations, the information processing apparatus determines a possible migration to be performed.

Abstract: A system includes a plurality of information processing devices and a management device configured to manage execution of jobs performed by the plurality of information processing devices. The management device detects any one of the plurality of information processing devices which is executing a first job, at a predetermined time, and determines whether a second information processing device different from the first information processing device is able to be allocated to a second job which is scheduled to use the first information processing device being used by the first job after the predetermined time, among the plurality of information processing devices. The management device modifies an execution schedule of the jobs such that the second job is executed using the second information processing device when it is determined that the second information processing device is able to be allocated to the second job.

Abstract: Described herein are methods for treating bone diseases or defects. The methods include administering to a host animal therapeutically effective amounts of one or more compounds that are selective inhibitors of dephosphorylation of eIF2?.

Abstract: Described herein are compounds, compositions, and methods useful for treating bone diseases or defects. Also described herein are compounds, compositions and methods for treating bone diseases or defects by inhibiting phosphatase complexes.

Abstract: A system includes a plurality of information processing devices and a management device configured to manage execution of jobs performed by the plurality of information processing devices. The management device detects any one of the plurality of information processing devices which is executing a first job, at a predetermined time, and determines whether a second information processing device different from the first information processing device is able to be allocated to a second job which is scheduled to use the first information processing device being used by the first job after the predetermined time, among the plurality of information processing devices. The management device modifies an execution schedule of the jobs such that the second job is executed using the second information processing device when it is determined that the second information processing device is able to be allocated to the second job.

Abstract: A method is disclosed for the in vivo treatment of a breast cancer tumor utilizing a therapeutically effective amount of an agent that inactivates the Rac1 GTPase and results in a reduction in cancer cell invasion, reduced cancer cell motility, and reduced volume and weight of the tumor. Agents that can be used in this treatment include salubrinal, guanabenz, and combinations thereof. The agents additionally have proven useful in reducing the development of osteoclastogenesis and reducing bone metastasis.