Abstract: The present invention provides a stable percutaneous absorption-type pharmaceutical preparation for the percutaneous absorption of basic drugs which does not cause a decrease in the cohesive force of the pressure-sensitive adhesive layer even in the presence of sweat components due to perspiration during wear; and a process for producing the pharmaceutical preparation. The percutaneous absorption-type pharmaceutical preparation comprises a substrate and, superposed on one side thereof in this order, a pressure-sensitive adhesive layer (A) comprising a pressure-sensitive adhesive and a basic drug and a pressure-sensitive adhesive layer (B) comprising a pressure-sensitive adhesive crosslinked with a crosslinking agent which is other than an organometallic compound, metal alcoholate, and metal chelate compound.

Abstract: The present invention provides a percutaneous absorption preparation which hardly causes the coloration phenomenon and is excellent in the stability of the drug content. The percutaneous absorption preparation comprises a support and a pressure-sensitive adhesive layer formed on at least one side of the support, wherein the pressure-sensitive adhesive layer contains a percutaneous absorptive drug and at least one of 2-mercaptobenzimidazole and propyl gallate, with the proviso that the percutaneous absorptive drug is not 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole and pharmacologically acceptable salt thereof.

Abstract: The present invention relates to a percutaneous preparation comprising an adhesive layer formed on at least one side of a substrate, the layer containing an acrylic copolymer, 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole or an acid addition salt thereof, and 2-mercaptobenzimidazole. This preparation exhibits superior percutaneous absorption of the benzimidazole compound and long sustention of efficacy, and shows an improved stability of the active ingredient, benzimidazole compound, in the preparation.