Patents by Inventor Hiroko Isoda
Hiroko Isoda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230113829Abstract: The invention provides an HIF-1 activator for treatment, prevention, alleviation, improvement or recovery from diseases or symptoms associated with reduced HIF-1 activity, as well as a pharmaceutical composition, cosmetic and food composition comprising the activator. Provided is an HIF-1 activator comprising olive leaf extract. Also provided is an HIF-1 activator which is for maintaining the undifferentiated state of stem cells via HIF-1 activation and/or improving dysdifferentiation of stem cells.Type: ApplicationFiled: October 4, 2022Publication date: April 13, 2023Applicants: NUTRITION ACT. CO.,LTD., UNIVERSITY OF TSUKUBAInventors: HIROKO ISODA, SHINJI KONDO, FARHANA FERDOUSI, MASAHITO ISHIKAWA, YOUKO WATANABE, KEN YAMAUCHI, MIKI YOKOZAWA
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Publication number: 20220241308Abstract: Provided is a neuronal function modulating agent effective for neuronal cell protection and exerts a neuronal function modulating effect through neuronal cell protection. The disclosed neuronal function modulating agent comprises malvidin-3,5-diglucoside as an active ingredient, the disclosed pharmaceutical composition comprises the neuronal function modulating agent, and the disclosed food composition comprises the neuronal function modulating agent.Type: ApplicationFiled: May 22, 2020Publication date: August 4, 2022Applicants: University of Tsukuba, National Institute of Advanced Industrial Science and Technology, ZEON CORPORATIONInventors: Hiroko ISODA, Kazunori SASAKI, Kazuhiko SATO, Masumi ASAKAWA, Kenichi TOMINAGA, Hiroshi FUJISAWA, Masami KOSHIYAMA
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Publication number: 20220233626Abstract: Provided is a grape pericarp extract that exhibits neuronal function modulating effects. The grape pericarp extract comprises 15 mg/g or more of malvidin-3,5-diglucoside in dry mass.Type: ApplicationFiled: May 22, 2020Publication date: July 28, 2022Applicants: University of Tsukuba, National Institute of Advanced Industrial Science and Technology, ZEON CORPORATIONInventors: Hiroko ISODA, Kazunori SASAKI, Kazuhiko SATO, Masumi ASAKAWA, Kenichi TOMINAGA, Hiroshi FUJISAWA, Masami KOSHIYAMA
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Patent number: 9420820Abstract: The present invention relate to a highly efficient and novel method, using clean technologies, for obtaining a natural bioactive concentrate that is rich on polyphenols from olive mill water (OMW). The clean technologies integrate centrifugation, a drowning-out crystallization-based separation process, and vacuum evaporation. The method provides a highly-concentrated polyphenol isolate (up to 99% (mass fraction)) from other components presents in OMW, with up to half of the polyphenol content being hydroxytyrosol. The isolated polyphenols exhibit anti-oxidant, anti-microbial, anti-inflammatory, and anti-carcinogenic activities; they can be prepared as solid particles, as an aqueous solution, in an emulsion, or as lipidic-based nanoparticles. The isolated polyphenols can be used in the food industry, cosmetic industry, or pharmaceutical industry.Type: GrantFiled: August 9, 2013Date of Patent: August 23, 2016Assignees: University of Tsukuba, Center of Biotechnology of Sfax, University of Sfax, MESRSInventors: Mitsutoshi Nakajima, Marcos Neves, Hiroko Isoda, Ilyes Dammak, Sami Sayadi
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Publication number: 20150045449Abstract: The present invention relate to a highly efficient and novel method, using clean technologies, for obtaining a natural bioactive concentrate that is rich on polyphenols from olive mill water (OMW). The clean technologies integrate centrifugation, a drowning-out crystallization-based separation process, and vacuum evaporation. The method provides a highly-concentrated polyphenol isolate (up to 99% (mass fraction)) from other components presents in OMW, with up to half of the polyphenol content being hydroxytyrosol. The isolated polyphenols exhibit anti-oxidant, anti-microbial, anti-inflammatory, and anti-carcinogenic activities; they can be prepared as solid particles, as an aqueous solution, in an emulsion, or as lipidic-based nanoparticles. The isolated polyphenols can be used in the food industry, cosmetic industry, or pharmaceutical industry.Type: ApplicationFiled: August 9, 2013Publication date: February 12, 2015Applicants: Center of Biotechnology of Sfax, University of Sfax, MESRS, UNIVERSITY OF TSUKUBAInventors: Mitsutoshi Nakajima, Marcos Neves, Hiroko Isoda, Ilyes Dammak, Sami Sayadi
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Publication number: 20140147848Abstract: The present disclosure provides a method for assessing the environmental effects of alkylbenzenesulfonate (LAS). For example, the method includes contacting a population of cells with a sample, measuring an expression level of one or more LAS biomarkers in the cell population, comparing the level of expression of the one or more LAS biomarker to one or more reference values corresponding to the one or more LAS biomarkers, and determining an LAS risk associated with the sample.Type: ApplicationFiled: November 26, 2012Publication date: May 29, 2014Applicants: CENTER OF BIOTECHNOLOGY OF SFAX, UNIVERSITY OF TSUKUBAInventors: Hiroko Isoda, Junkyu Han, Sayadi Sami, Mohamed Bradai
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Publication number: 20140148399Abstract: Obesity is one of the major health concerns in the Twenty-First Century and is one of the leading causes of preventable death. It is a strong risk factor for Type 2 Diabetes. Disclosed herein are compositions and methods using Nitraria retusa extracts for enhancing energy metabolism, inhibiting fat accumulation, inhibiting preadipocyte differentiation, reducing diabetic hypercholesterolemia, and for treating or ameliorating obesity.Type: ApplicationFiled: November 26, 2012Publication date: May 29, 2014Applicants: CENTER OF BIOTECHNOLOGY OF BORJ CEDRIA, UNIVERSITY OF TSUKUBAInventors: Hiroko Isoda, Junkyu Han, Zar Kalai Feten, Chedly Abdelly, Riadh Ksouri
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Publication number: 20140147527Abstract: Cymbopogon schoenanthus is used in folk medicine in North-African for the treatment of rheumatism and to diminish fever. However, whether it possesses anti-stress properties had not previously been established in vivo. Disclosed herein are data demonstrating the effectiveness of C. schoenanthus ethanol extracts on stressors in vitro (heat shock and oxidative stress) and on stressors in vivo (forced swimming test and tail suspension test). Moreover, disclosed are statistically significant anti-stress effects in vivo which occur in a dose-dependent manner. Additionally, the effects of C. schoenanthus ethanol extract exposure is shown to be comparable to a commercially-available antidepressant drug. Accordingly, C. schoenanthus ethanol extracts are useful in new compositions and methods for treating or ameliorating emotional-psychological stress.Type: ApplicationFiled: November 26, 2012Publication date: May 29, 2014Applicants: INSTITUTE OF ARID REGIONS, TUNISIA, TSUKUBA UNIVERSITYInventors: Hiroko Isoda, Junkyu Han, Mahmoud Ben Othman, Mohamed Neffati
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Publication number: 20080160111Abstract: The present invention aims to elucidate the relationship between fulvic acid contained in a humic substance and the onset mechanism of the type I allergy, and inhibits the onset of the type I allergy using the fulvic acid. The present invention provides a type I allergy inhibitor which inhibits an antigen sensitization phase or/and an antibody sensitization phase, and the degranulation phase of cells with fulvic acid and a composition containing at least the fulvic acid. Moreover, the present invention provides a method for inhibiting the onset of the type I allergy by performing a specific hyposensitization treatment using the fulvic acid and, in particularly, a method for inhibiting an antigen sensitization phase or/and an antibody sensitization phase with fulvic acid. Or, the present invention provides a method for inhibiting the onset of the type I allergy by performing a nonspecific hyposensitization treatment using fulvic acid.Type: ApplicationFiled: January 5, 2006Publication date: July 3, 2008Inventors: Hiroko Isoda, Parida Yamada, Yukuo Abe
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Patent number: 6833266Abstract: A mushroom fungus belonging to the order of Agaricales, is cultured with good efficiency by using a liquid culture medium in such a way as to prepare the mycelia separated from the culture medium such that the culturing liquid can be served for food use. A liquid culture medium containing 3 to 16 g/liter of sucrose and 1 to 6 g/liter of maltose as a carbon source and 0.3 to 1.2 g/liter of yeast extract as a nitrogen source is inoculated with Agaricus mycelia and culturing is conducted by blowing into the culture medium sterilized air of 20 to 90% of the oxygen concentration.Type: GrantFiled: January 25, 2002Date of Patent: December 21, 2004Assignee: Tsukuba Biosystem, Ltd.Inventors: Takaaki Maekawa, Hiroko Isoda
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Patent number: 6740521Abstract: The present invention provides a bioassay system, for detection of hazardous chemical substances, natural toxic substances in the environment and unknown toxic compounds, with high sensitivity, simplicity and speed. The invention provides cells and a method of using the cells for use in the bioassay system. The cell provided by the invention contains a heat shock factor binding DNA sequence and a transcriptional regulatory sequence necessary on an occasion of stress induction as a transcriptional regulatory factor binding site. The cell also possesses a reporter gene under the control of the promoter. The reporter gene is connected, on the downstream side, to the SV40pA signal without any intervening intron.Type: GrantFiled: March 11, 2002Date of Patent: May 25, 2004Assignees: Kaneka Corporation, Agency of Industrial Science and Technology, Ministry of International Trade and IndustryInventors: Hiroko Isoda, Takashi Koyama, Masako Tasaki, Syuichi Oka, Norio Sugiura, Takaaki Maekawa, Yuhei Inamori, Shinichi Yokota, Mikio Kitahara, Kazuhiro Nagata
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Publication number: 20030104006Abstract: Disclosed is a novel hyaluronidase activity and allergenic cell activity inhibitive substance useful as an effective ingredient in an anti-inflammatory or antiallergic medicament, which is an ethyl alcohol extract from body tissues or mycelia tissues of a fungus Agaricus blazei. The desired inhibitive activity of the ethyl alcohol extract is significantly higher than the corresponding hot water extract of the same fungous tissues. This difference is very prominent when the Agaricus blazei fungus cultured in a culture medium containing wheat bran and pinewood chips in combination is used as the starting material of the ethyl alcohol extraction.Type: ApplicationFiled: September 26, 2002Publication date: June 5, 2003Inventors: Takaaki Maekawa, Hiroko Isoda
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Publication number: 20030082793Abstract: A physiologically active extract is prepared by disintegrating mycelial bodies of agaricus fungus belonging to the basidiomycetous order of matsutake to give a disintegrated material, heating a slurry containing the disintegrated material or keeping a slurry containing the disintegrated material with addition of ethyl alcohol or a mixture of ethyl alcohol and water and removing solid materials from the slurry. The physiologically active extract is useful for therapy of dementia and Alzheimer's disease.Type: ApplicationFiled: August 27, 2002Publication date: May 1, 2003Inventors: Takaaki Maekawa, Hiroko Isoda
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Publication number: 20030049737Abstract: The present invention is aimed to provide a bioassay system that can detect hazardous chemical substances or natural toxic substances in the environment, inclusive of the unknown homologs, with high sensitivity, simplicity and speed.Type: ApplicationFiled: March 11, 2002Publication date: March 13, 2003Applicant: KANEKA CORPORATION AND THE NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (AIST),Inventors: Hiroko Isoda, Takashi Koyama, Masako Tasaki, Syuichi Oka, Norio Sugiura, Takaaki Maekawa, Yuhei Inamori, Shinichi Yokota, Mikio Kitahara, Kazuhiro Nagata
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Publication number: 20030005488Abstract: A fungus belonging to the order of Agaricales, such as mushroom, is cultured with good efficiency by using a liquid culture medium in such a way as to prepare the mycelia separated from the culture medium and the culturing liquid thereof can be served as such for food use. A liquid culture medium containing 3 to 16 g/liter of sucrose and 1 to 6 g/liter of maltose as the carbon source and 0.3 to 1.2 g/liter of yeast extract as the nitrogen source is inoculated with Agaricus mycelia and culturing is conducted by blowing thereinto sterilized air of 20 to 90% of the oxygen concentration.Type: ApplicationFiled: January 25, 2002Publication date: January 2, 2003Inventors: Takaaki Maekawa, Hiroko Isoda
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Patent number: 5330975Abstract: Sialic acid binding proteins, sialic acid-binding peptides and sialic acid containing oligo-saccharides are active ingredients of a novel bacterial enterotoxin neutralizer and interfere with the binding of enterotoxins, including cholera toxin, to receptors so as to exert an effect of neutralizing the toxicity, thus being utilized as an effective neutralizer and are safe and available cheaply and abundantly from by-products produced during the processing of cow's milk which renders the enterotoxin neutralizer economically advantageous for commercial use.Type: GrantFiled: July 14, 1992Date of Patent: July 19, 1994Assignee: Snow Brand Milk Products Co., Ltd.Inventors: Hiroko Isoda, Yoshihiro Kawasaki, Morimasa Tanimoto, Shunichi Dosako, Tadashi Idota
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Patent number: 5260280Abstract: Sialic acid binding proteins, sialic acid-binding peptides and sialic acid containing oligo-saccharides are active ingredients of a novel bacterial enterotoxin neutralizer and interfere with the binding of enterotoxins, including cholera toxin, to receptors so as to exert an effect of neutralizing the toxicity, thus being utilized as an effective neutralizer and are safe and available cheaply and abundantly from by-products produced during the processing of cow's milk which renders the enterotoxin neutralizer economically advantageous for commercial use.Type: GrantFiled: July 14, 1992Date of Patent: November 9, 1993Assignee: Snow Brand Milk Products Co., Ltd.Inventors: Hiroko Isoda, Yoshihiro Kawasaki, Morimasa Tanimoto, Shunichi Dosako, Tadashi Idota