Abstract: A compound of formula (I) or a salt thereof: wherein, R1 represents a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group and so on; R2 represents a hydrogen atom, or a C1-6 alkyl group, R3 and R4 each independently represent a hydrogen atom, or a C1-6 alkyl group, R5 represents a substituted or unsubstituted C1-6 alkyl group and so on; Y represents a C1-6 haloalkyl group, X represents a halogeno group, a C1-6 alkyl group and so on; and n represents the number of chemically acceptable groups represented by X and is an integer of 0 to 4, and when n is 2 or more, the groups X is the same as or different from each other.

Abstract: A compound of formula (I) or a salt thereof: wherein, R1 represents a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group and so on; R2 represents a hydrogen atom, or a C1-6 alkyl group, R3 and R4 each independently represent a hydrogen atom, or a C1-6 alkyl group, R5 represents a substituted or unsubstituted C1-6 alkyl group and so on; Y represents a C1-6 haloalkyl group, X represents a halogeno group, a C1-6 alkyl group and so on; and n represents the number of chemically acceptable groups represented by X and is an integer of 0 to 4, and when n is 2 or more, the groups X is the same as or different from each other.

Abstract: A medicinal active ingredient is provided which is useful for the treatment or prevention of inflammatory diseases, diseases caused by lipid oxidation, retinochoroidal disorders. A phenylimidazole derivative represented by Formula (IB) or a salt thereof is provided. A therapeutic medicine or preventive medicine is provided for inflammatory diseases, diseases caused by lipid oxidation, or retinochoroidal disorders, the medicine including at least one selected from the phenylimidazole derivative, a salt thereof, and metabolites thereof as an active ingredient. In Formula (IB), R1a represents an alkyl group etc., R2 represents an amino group etc., R3 represents a halogen atom, an alkyl group etc., R4 represents a cyano group etc., R5 represents an alkyl group etc., and R6 represents an alkyl group etc.

Abstract: The present invention is directed to compounds represented by the formula (1): B-D-Z (1), wherein B represent the following formula (B-1), A represents an optionally substituted imidazole or pyrazole group; E represents the following formula (1a): X represents an oxygen atom, the formula: SOu, or the formula: N—R9; Y represents a carbon atom or a nitrogen atom; D represents an oxygen atom, a sulfur atom or the formula (1a); Z represents (a chroman-2-yl group, a chroman-4-yl group, a 2,3-dihydrobenzofuran-2-yl group, a 2,3-dihydrobenzofuran-3-yl group, etc.) which is substituted with NHR10 or OR11)] or pharmaceutically acceptable salts thereof, and to antioxidants, therapeutic agents for kidney diseases or cerebrovascular disorder, and retinal oxidative damage inhibitors, which include the compounds as the active ingredient.

Abstract: The present invention is directed to compounds represented by the formula (1): B-D-Z??(1) [wherein B represent the following formula (B-1), (B-2) or (B-3); A represents an optionally substituted imidazole or pyrazole group; E represents the following formula (1a): X represents an oxygen atom, the formula: SOu, or the formula: N—R9; Y represents a carbon atom or a nitrogen atom; D represents an oxygen atom, a sulfur atom or the formula (1a); Z represents (a chroman-2-yl group, a chroman-4-yl group, a 2,3-dihydrobenzofuran-2-yl group, a 2,3-dihydrobenzofuran-3-yl group, etc.) which is substituted with NHR10 or OR11)] or pharmaceutically acceptable salts thereof, and to antioxidants, therapeutic agents for kidney diseases or cerebrovascular disorder, and retinal oxidative damage inhibitors, which include the compounds as the active ingredient.