Patents by Inventor Hiroko Ogino
Hiroko Ogino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6093714Abstract: Tricyclic benzazepine compounds represented by the following formula (I) and pharmacologically acceptable salts thereof are disclosed. These compounds have antiallergic activity and are useful for treatment and prevention of bronchial asthma, eczema, hives, allergic gastrointestinal troubles, allergic rhinitis, allergic conjunctivitis, etc. wherein R represents a hydrogen atom, substituted C.sub.1-6 alkyl or a protective group and R.sup.1, R.sup.2, R.sup.3, and R.sup.4 represent a hydrogen atom, a hydroxyl group, substituted C.sub.1-4 alkyl, substituted C.sub.2-12 alkenyl, substituted C.sub.1-12 alkoxy, or substituted amino.Type: GrantFiled: June 17, 1998Date of Patent: July 25, 2000Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yasuo Ohtsuka, Toshio Nishizuka, Sohjiro Shiokawa, Seiji Tsutsumi, Kenichi Fusihara, Mami Kawaguchi, Megumi Imai, Keiko Shito, Koji Tsuchiya, Takako Iwasaki, Hiroko Ogino, Takashi Shishikura
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Patent number: 5840895Abstract: Compounds of formulae (II), (III), (IV) and (V) or salts thereof are intermediates for pharmacologically active tricyclic benzazepine and benzothiazepine derivatives, ##STR1## wherein R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl, and R.sup.41 represents hydrogen, C.sub.1-6 alkyl which may be optionally substituted, or a protective group for a carboxyl group.Type: GrantFiled: June 26, 1997Date of Patent: November 24, 1998Assignee: Meiji Seika Kabushiki KaishaInventors: Yasuo Ohtsuka, Takashi Shishikura, Hiroko Ogino, Kenichi Fushihara, Mami Kawaguchi, Seiji Tsutsumi, Megumi Imai, Keiko Shito, Koji Tsuchiya, Junko Tanaka, Takako Iwasaki, Shigeru Hoshiko, Takashi Tsuruoka
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Patent number: 5686442Abstract: The tricyclic benzazepine and benzothiazepine derivatives represented by the formula (I) and pharmacologically acceptable salts thereof are disclosed. ##STR1## wherein Z represents CO, --CR.sup.6 R.sup.7 -- or --S(O).sub.n, R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl. These compounds have anti-allergic effect and are useful for the treatment and prophylaxis of allergic diseases.Type: GrantFiled: October 26, 1995Date of Patent: November 11, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Yasuo Ohtsuka, Takashi Shishikura, Hiroko Ogino, Kenichi Fushihara, Mami Kawaguchi, Seiji Tsutsumi, Megumi Imai, Keiko Shito, Koji Tsuchiya, Junko Tanaka, Takako Iwasaki, Shigeru Hoshiko, Takashi Tsuruoka
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Patent number: 5399566Abstract: The invention provides compounds represented by the following formula (I) ##STR1## or a pharmaceutically acceptable salts thereof wherein A represents ##STR2## B represents a carboxy or tetrazolyl group; and X represents --O--, --NH-- or --S(O).sub.t --.The compounds possess angiotensin II antagonism, and may be used as an antihypertensive agent, a therapeutic agent to congestive heart failure, an antianxiety agent and a cognitive enhancing agent.Type: GrantFiled: September 10, 1991Date of Patent: March 21, 1995Assignee: Meiji Seika Kabushiki KaishaInventors: Kiyoaki Katano, Hiroko Ogino, Eiki Shitara, Hiromi Watanabe, Jun Nagura, Naomi Osada, Yasuyuki Ichimaru, Fukio Konno, Tomoya Machinami, Takashi Tsuruoka
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Patent number: 5200407Abstract: Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.Type: GrantFiled: June 14, 1991Date of Patent: April 6, 1993Assignee: Meiji Seika Kaburhiki KaishaInventors: Kiyoaki Katano, Tamako Tomomoto, Hiroko Ogino, Naoki Yamazaki, Fumiya Hirano, Yasukatsu Yuda, Fukio Konno, Motohiro Nishio, Tomoya Machinami, Seiji Shibahara, Takashi Tsuruoka, Shigeharu Inouye
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Patent number: 5185347Abstract: A piperidine compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, a hydroxymethyl group, --CO.sub.2 R.sup.3, or ##STR2## wherein R.sup.3 represents a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms; R.sup.4 represents a hydroxyl group, a lower alkoxy group having from 1 to 4 carbon atoms or --NR.sup.6 R.sup.7 (wherein R.sup.6 and R.sup.7, which may be the same or different, each represent a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms); and R.sup.5 represents a hydrogen atom, a lower alkanoyl group having from 1 to 4 carbon atoms, or a chlorobenzoyl group; R.sup.Type: GrantFiled: May 16, 1991Date of Patent: February 9, 1993Assignee: Meiji Seika Kaisha Ltd.Inventors: Kiyoaki Katano, Tamako Tomomoto, Hiroko Ogino, Fumiya Hirano, Yasukatsu Yuda, Fukio Konno, Tomoya Machinami, Takashi Tsuruoka, Shigeharu Inoye
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Patent number: 5141946Abstract: Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in whichA, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represnts a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.Type: GrantFiled: June 14, 1991Date of Patent: August 25, 1992Assignee: Meiji Seika Kabushiki KaishaInventors: Kiyoaki Katano, Tamako Tomomoto, Hiroko Ogino, Naoki Yamazaki, Fumiya Hirano, Yasukatsu Yuda, Fukio Konno, Motohiro Nishio, Tomoya Machinami, Seiji Shibahara, Takashi Tsuruoka, Shigeharu Inouye
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Patent number: 5079255Abstract: Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.Type: GrantFiled: June 27, 1990Date of Patent: January 7, 1992Assignee: Meiji Seika Kabushiki KaishaInventors: Kiyoaki Katano, Tamako Tomomoto, Hiroko Ogino, Yamazaki Naoki, Fumiya Hirano, Yasukatsu Yuda, Fukio Konno, Motohiro Nishio, Tomoya Machinami, Seiji Shibahara, Takashi Tsuruoka, Shigeharu Inouye
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Patent number: 5028601Abstract: Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom or a nucleophilic compound residue or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.Type: GrantFiled: April 21, 1988Date of Patent: July 2, 1991Assignees: Meiji Saika Kaisha, Ltd., Zaidanhojin Biseibutsu Kagaku KenkyukaiInventors: Shinichi Kondo, Takashi Tsuruoka, Katsuyoshi Iwamatsu, Kiyoaki Katano, Satoru Nakabayashi, Hiroko Ogino, Takashi Yoshida, Masaji Sezaki
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Patent number: 4988686Abstract: Disclosed is a novel cephem compound which is either one of a cis- or trans-isomer or a mixture of the cis-and trans-isomers, represented by the following general formula (I) and a pharmacologically acceptable salt thereof: ##STR1## wherein all of the substituents are as defined hereinbefore. Also disclosed are a process for producing the above compound and its use as an anti-bacterial agent comprising the same.Type: GrantFiled: June 28, 1989Date of Patent: January 29, 1991Assignee: Meiji Seika Kabushiki KaishaInventors: Kunio Atsumi, Katsuyoshi Iwamatsu, Kenji Sakagami, Hiroko Ogino, Takashi Yoshida
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Patent number: 4785090Abstract: This is a class of antibacterial compounds of the formula: ##STR1## wherein Y is straight or branched alkyl or alkenyl chain, cycloalkanomethyl of 3-6 carbon atoms, each group being optionally substituted by halogen, or a group ##STR2## wherein n is 0 or an integer of 1-3, A is a group --COR.sup.3 wherein R.sup.3 is hydroxy, a group ##STR3## wherein R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or alkyl of 1-5 carbon atoms, a group ##STR4## or a 5- or 6-membered heterocyclic group containing nitrogen and/or sulfur, and R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, alkyl of 1-5 carbon atoms, or R.sup.1 and R.sup.2 may be combined together to form cycloalkylidene of 3-5 carbon atoms, and Z is a group of the formula: ##STR5## wherein m is 0 or an integer of 3-5, R.sup.6 is hydrogen or alkyl of 1-3 carbon atoms, and R.sup.7, when m is an integer of 3-5, is alkyl of 1-5 carbon atoms, alkenyl, cyclopropyl, a group --(CH.sub.2).sub.Type: GrantFiled: February 21, 1985Date of Patent: November 15, 1988Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takashi Tsuruoka, Seiji Shibahara, Katsuyoshi Iwamatsu, Tsuneo Okonogi, Satoru Nakabayashi, Yasushi Murai, Hiroko Ogino, Kiyoaki Katano, Takashi Yoshida, Shigeharu Inoue, Shunzo Fukatsu, Shinichi Kondo
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Patent number: 4758557Abstract: Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: ##STR1## wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); ##STR2## or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): ##STR3## or an unsubstituted or substituted pyridinium group of a formula (I-3); ##STR4## or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):--S--Het (I-4).Type: GrantFiled: June 9, 1986Date of Patent: July 19, 1988Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takashi Tsuruoka, Katsuyoshi Iwamatsu, Kiyoaki Katano, Hiroko Ogino, Ryoichi Okamoto, Takashi Yoshida, Masaji Sezaki, Fumio Kai, Shigeharu Inoue, Shinichi Kondo