Patents by Inventor Hiroko Okano

Hiroko Okano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING BRAIN ORGANOID INCLUDING AGGREGATED TAU PROTEIN
    Publication number: 20240151712
    Abstract: A method for producing a brain organoid having an aggregated tau protein including (a) culturing pluripotent stem cells in the presence of a SMAD inhibitor to form an embryoid body, (b) embedding the embryoid body in an extracellular matrix and three-dimensionally culturing the embryoid body in the presence of a SMAD inhibitor and a GSK3? inhibitor to form an organoid that includes neural precursor cells, (c) extracting the organoid from the extracellular matrix and suspension-culturing the organoid in the presence of LIF to form a brain organoid, (d) forcing the brain organoid to express a mutant MAPT gene, and (e) further suspension-culturing the brain organoid after (d) to obtain a brain organoid having an aggregated tau protein.
    Type: Application
    Filed: March 18, 2022
    Publication date: May 9, 2024
    Inventors: Hiroko ISHII, Hideyuki OKANO, Takahiro KONDO, Yuta SATO
  • Tire tread
    Patent number: D464025
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: October 8, 2002
    Assignee: The Goodyear Tire & Rubber Company
    Inventor: Hiroko Okano