Abstract: A novel therapeutic agent effective for the treatment of intellectual disability or autism is disclosed. The therapeutic agent for intellectual disability or autism contains, as an active component(s), at least one selected from the group consisting of tipifarnib and lonafarnib. Examples of the intellectual disability include memory impairment. Examples of the memory impairment include memory impairment caused by abnormality of the Tsc1 gene and/or Tsc2 gene, and epilepsy-induced memory impairment. Also provided is a method of treating intellectual disability or autism, comprising administering an effective amount of at least one selected from the group consisting of tipifarnib and lonafarnib to a patient with intellectual disability or autism.

Abstract: A novel therapeutic agent effective for the treatment of intellectual disability or autism is disclosed. The therapeutic agent for intellectual disability or autism contains, as an active component(s), at least one selected from the group consisting of tipifarnib and lonafarnib. Examples of the intellectual disability include memory impairment. Examples of the memory impairment include memory impairment caused by abnormality of the Tsc1 gene and/or Tsc2 gene, and epilepsy-induced memory impairment. Also provided is a method of treating intellectual disability or autism, comprising administering an effective amount of at least one selected from the group consisting of tipifarnib and lonafarnib to a patient with intellectual disability or autism.

Abstract: A topsheet for absorbent articles having absorbing performance for smoothly transferring liquid body waste, e.g., menstrual blood or urine, to an underlying absorbent member and surface characteristics such that the surface thereof in contact with wearer's skin is soft enough not to cause skin irritation. The topsheet 1 comprises a first layer 11 disposed on the side of a wearer and a second layer 12 disposed on the side of an absorbent member, the first layer and the second layer being partly joined together, and having protrusions and depressions on the side of a wearer, wherein the first and second layers each comprise a fiber aggregate, the first layer has fusion-bonded fiber intersections, the first layer has an apparent thickness (t1) of 0.1 to 5 mm, the second layer has an apparent thickness (t2) of 0.2 to 3 mm, the apparent thickness ratio of the first layer to the second layer (t1/t2) is 0.5 to 8, the first layer has a fiber density (d1) of 0.001 to 0.

Abstract: A topsheet for absorbent articles is disclosed. The topsheet is used on the side of an absorbent article to be brought into contact with a wearer's body. The topsheet has an air permeability of 10 ml/cm2·sec or more in the horizontal direction under a pressure of 10 cN/cm2. The topsheet also has an air permeability of 10 to 500 ml/cm2·sec in the horizontal direction under a pressure of 50 cN/cm2.

Abstract: A topsheet for an absorbent article which has an uneven profile formed on a surface thereof to be brought into contact with a wearer's skin, the uneven profile being flexibly deformable in conformity to the contour of the wearer's body and to the wearer's movement, and depressions of the uneven profile being capable of trapping high-viscosity excreta thereby separating the high-viscosity excreta from the wearer's skin while an absorbent article having the topsheet is worn.

Abstract: A topsheet for an absorbent article which has an uneven profile formed on a surface thereof to be brought into contact with a wearer's skin, the uneven profile being flexibly deformable in conformity to the contour of the wearer's body and to the wearer's movement, and depressions of the uneven profile being capable of trapping high-viscosity excreta thereby separating the high-viscosity excreta from the wearer's skin while an absorbent article having the topsheet is worn.

Abstract: A topsheet for an absorbent article which has an uneven profile formed on a surface thereof to be brought into contact with a wearer's skin, the uneven profile being flexibly deformable in conformity to the contour of the wearer's body and to the wearer's movement, and depressions of the uneven profile being capable of trapping high-viscosity excreta thereby separating the high-viscosity excreta from the wearer's skin while an absorbent article having the topsheet is worn.

Abstract: A topsheet 10 for an absorbent article comprising a first fiber layer 1 disposed on the side of a wearer and a second fiber layer 2 disposed on the side of an absorbent member, the first fiber layer 1 and the second fiber layer 2 being partially bonded together at joints 3 in a prescribed pattern, the first fiber layer 1 having protrusions 4 on the wearer's side in portions other than the joints 3, and the second fiber layer 2 being a fiber aggregate containing heat shrinkable fiber and having heat shrunken parts 5 that have shrunken and densified parts 6 that have been inhibited from heat shrinkage.

Abstract: An absorbent article having a substantially oblong shape and comprising a liquid permeable topsheet, a liquid impermeable backsheet, and a liquid retentive absorbent member interposed between the topsheet and the backsheet is disclosed. The topsheet is a bulky sheet which exhibits elastomeric behavior as a whole and comprises a first layer disposed on the side of a wearer and a second layer disposed on the side of the absorbent member. The first layer and the second layer are partially bonded together at joints in a prescribed pattern. The first layer has protrusions on the side of a wearer in portions other than the joints. The second layer is made of a material exhibiting elastomeric behavior. The topsheet is fixed in an extended state in at least one of the longitudinal direction and the width direction of the absorbent article.

Abstract: A topsheet 10 for an absorbent article comprising a first fiber layer 1 disposed on the side of a wearer and a second fiber layer 2 disposed on the side of an absorbent member, the first fiber layer 1 and the second fiber layer 2 being partially bonded together at joints 3 in a prescribed pattern, the first fiber layer 1 having protrusions 4 on the wearer's side in portions other than the joints 3, and the second fiber layer 2 being a fiber aggregate containing heat shrinkable fiber and having heat shrunken parts 5 that have shrunken and densified parts 6 that have been inhibited from heat shrinkage.

Abstract: A topsheet for absorbent articles having absorbing performance for smoothly transferring liquid body waste, e.g., menstrual blood or urine, to an underlying absorbent member and surface characteristics such that the surface thereof in contact with wearer's skin is soft enough not to cause skin irritation. The topsheet 1 comprises a first layer 11 disposed on the side of a wearer and a second layer 12 disposed on the side of an absorbent member, the first layer and the second layer being partly joined together, and having protrusions and depressions on the side of a wearer, wherein the first and second layers each comprise a fiber aggregate, the first layer has fusion-bonded fiber intersections, the first layer has an apparent thickness (t1) of 0.1 to 5 mm, the second layer has an apparent thickness (t2) of 0.2 to 3 mm, the apparent thickness ratio of the first layer to the second layer (t1/t2) is 0.5 to 8, the first layer has a fiber density (d1) of 0.001 to 0.

Abstract: A topsheet for absorbent articles is disclosed. The topsheet is used on the side of an absorbent article to be brought into contact with a wearer's body. The topsheet has an air permeability of 10 ml/cm2·sec or more in the horizontal direction under a pressure of 10 cN/cm2. The topsheet also has an air permeability of 10 to 500 ml/cm2·sec in the horizontal direction under a pressure of 50 cN/cm2.

Abstract: A topsheet for an absorbent article which has an uneven profile formed on a surface thereof to be brought into contact with a wearer's skin, the uneven profile being flexibly deformable in conformity to the contour of the wearer's body and to the wearer's movement, and depressions of the uneven profile being capable of trapping high-viscosity excreta thereby separating the high-viscosity excreta from the wearer's skin while an absorbent article having the topsheet is worn.