Abstract: The present invention provides the compound, 3-[(1S,2S)-1-[5-[(4S)-2,2-Dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a pharmaceutically acceptable salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound.

Abstract: A nebulizer system of the present invention includes a computer device and a nebulizer head directly connected to the computer device by a USB cable. The computer device supplies a DC voltage through a Vbus line and a GND line of the USB cable, and supplies a control signal having a square waveform through a D+ line and a D? line of the USB cable. The nebulizer head includes a first resonance circuit including a first coil and a first capacitor, a conversion circuit that applies a DC voltage intermittently or alternately polarity-reversedly according to a control signal of the first resonance circuit to generate an AC voltage having a sinusoidal waveform, and an atomizer that is driven by the AC voltage having the sinusoidal waveform and atomizes and ejects a liquid.

Abstract: In a nebulizer of the present invention, a main body is being mounted with a power supply unit and an oscillation unit generating an oscillation output including a first frequency component and a second frequency component different from each other. A first replacement member is being mounted with an atomization unit configured to atomize, using the first frequency component, a first liquid that is supplied. A second replacement member is being mounted with an atomization unit configured to atomize, using the second frequency component, a second liquid that is supplied. The first and/or the second replacement members include a functional unit configured to operate with an additional frequency component different from the first and second frequency components. A replacement member attached to the main body receives the oscillation output including the first, second and additional frequency components from the main body.

Abstract: A nebulizer comprising a power supply system of the present invention performs wireless power supply from a power transmission-side circuit to a power reception-side circuit. The power transmission-side circuit transmits a power to the power reception-side circuit at a certain oscillation frequency through a power transmission coil. In the power reception-side circuit, a power reception coil and a load configure a power reception-side resonance circuit to determine a resonance frequency of the power reception-side resonance circuit. When the resonance frequency of the power reception-side resonance circuit changes due to a change in an impedance of a load during power supply, a control unit controls an oscillation frequency to maintain a power transmission efficiency from the power transmission-side circuit to the power reception-side circuit.

Abstract: A method for manufacturing a blood pressure information measurement apparatus includes the following steps: forming a hole in a flexible resin sheet; inserting a connecting pipe into the hole; overlaying a first end portion and a second end portion of the flexible resin sheet such that an inner side of the first end portion contacts an outer side of the second portion; welding a location at which the first end portion and the second end portion overlap to form a first welded portion, such that the flexible resin sheet forms a tube-shaped body having a first end and a second end; flattening the tube-shaped body; welding the first end and the second to form two second welded portions, such that the tube-shaped body forms a bladder having two long sides and two short sides; and welding portions of the resin sheet which overlap along a first long side to form one or more partial welded portions.

Abstract: In a main body of an upper-arm type sphygmomanometer that measures blood pressure of a subject by using a bag-shaped arm cuff to be wound around an arm of the subject, a main body housing includes an upper surface, and a first side surface and a second side surface on left and right sides. The first side surface includes a first side surface electrode region, the second side surface includes a second side surface electrode region, the upper surface includes a first upper surface electrode region, a first electrocardiogram waveform measurement electrode is provided in the first side surface electrode region, a second electrocardiogram waveform measurement electrode is provided in the second side surface electrode region, and a first reference electrode is provided in the first upper surface electrode region.

Abstract: A method for manufacturing a blood pressure information measurement apparatus includes the following steps: forming a hole in a flexible resin sheet; inserting a connecting pipe into the hole; overlaying a first end portion and a second end portion of the flexible resin sheet such that an inner side of the first end portion contacts an outer side of the second portion; welding a location at which the first end portion and the second end portion overlap to form a first welded portion, such that the flexible resin sheet forms a tube-shaped body having a first end and a second end; flattening the tube-shaped body; welding the first end and the second to form two second welded portions, such that the tube-shaped body forms a bladder having two long sides and two short sides; and welding portions of the resin sheet which overlap along a first long side to form one or more partial welded portions.

Abstract: A blood pressure information measurement cuff includes a band-shaped cuff body and a fluid bladder that is connected to the cuff body and is configured to expand/contract with insertion or discharge of a fluid, the blood pressuring information measurement cuff being configured to be used while wrapped around a body being examined. The fluid bladder is formed into a rectangular bag shape by flattening a tube-shaped resin sheet and sealing the two end portions thereof that form openings. A partial welded portion, which is formed by the resin sheet being folded so as to overlap itself and welded, is formed on at least a portion of one of a pair of opposing sides that intersect the sides of the two sealed end portions and extend in a wrapping direction on the body being examined.

Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.

Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.

Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.

Abstract: A compound of the formula (I) in which R1 is —OR11, —SR11, —SOR11, —SO2R11, —NHR11, or —NR12R13 , and R11, R12, and R13 are as defined broadly in the text. R2 is H, C1-C6alkyl, carbamoyl, or an ester group. R3 is thienyl, pyridyl optionally substituted by halogen or C1-C6alkoxy; naphthyl optionally substituted by C1-C6alkoxy; dioxane fused phenyl; dioxacyclopentane fused phenyl; or optionally substituted phenyl. Y is CH or N. A process for preparing such compounds, pharmaceutical compositions containing such compounds, and a method of treating asthma using them are also disclosed and claimed.

Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.

Abstract: A compound of the formula (I) wherein R1 is —X—R4, an optionally substituted heterocyclic residue, an optionally substituted carbocyclic residue or optionally substituted condensed ring moiety; X is CR5R6, O, S, SO, SO2 or NR7; Y is CH or N; R2 is H, an optionally substituted C1-C10 alkyl,etc.; R3 is an optionally substituted aryl, or an optionally substituted heteroaryl, etc.; R4 is an optionally substituted aryl, an optionally substituted heteroaryl, etc.; R5, R6, and R7 can be identical or different and represent H, an optionally substituted C1-C10 alkyl, etc. The compound has an excellent anti-allergic activity and the like.

Abstract: An ATM switching system concentrates cell streams, which are output by respective ones of a plurality of line interfaces, by a concentrator, enters a resulting cell stream into an ATM switch unit, deconcentrates cells, which have been switched by the ATM switch unit, by a deconcentrator on a per line interface basis and sends the cells to lines. Each line interface converts a VPI/VCI included in the header of a cell that has entered from a line to an internal cell address having a number of bits smaller than the number of bits of the VPI/VCI. Each unit in the ATM switching system performs management of various data and controls cell switching based upon a converted cell address without relying upon the VPI/VCI. The line interface restores an internal cell address, which is included in the header of a cell that enters from the side of the ATM switch, to the VPI/VCI and sends the cell to a line.