Patents by Inventor Hiromasa Kohama
Hiromasa Kohama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11969525Abstract: Disclosed is a method for producing a medical instrument having a lubricating layer (a coating layer) exhibiting excellent durability (particularly, sliding durability). The method for producing a medical instrument is a method for producing a medical instrument having a base layer, and a lubricating layer that is carried on at least a part of the base layer. The method for producing a medical instrument also includes applying, to the base layer, a solution containing a block copolymer having a structural unit (A) derived from a reactive monomer having an epoxy group and a structural unit (B) derived from a hydrophilic monomer, an alkylammonium salt having 8 to 24 carbon atoms, and a solvent; and washing off the solution applied to the base layer.Type: GrantFiled: March 4, 2020Date of Patent: April 30, 2024Assignee: TERUMO KABUSHIKI KAISHAInventor: Hiromasa Kohama
-
Publication number: 20220168475Abstract: A medical device that exhibits an excellent lubricating property includes: a substrate layer; and a surface lubricious layer formed on at least a part of the substrate layer, and containing a hydroxy group-containing compound selected from a group consisting of a non-volatile alcohol, a partially esterified product thereof, and a partially etherified product thereof, and soluble in water, and a hydrophilic copolymer containing a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from a group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and salt groups thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group.Type: ApplicationFiled: February 18, 2022Publication date: June 2, 2022Applicant: TERUMO KABUSHIKI KAISHAInventors: Yuki UENO, Masanori KURAMOTO, Hiroki HOSONO, Hiromasa KOHAMA
-
Publication number: 20210379250Abstract: A method for manufacturing a medical instrument having a lubricating layer (coating layer) that exhibits excellent durability (particularly, sliding durability) is provided. The method for manufacturing a medical instrument is a method for manufacturing a medical instrument that includes a base layer and a lubricating layer carried on at least a portion of the base layer. The method includes applying a solution including a block copolymer having a structural unit derived from a reactive monomer having an epoxy group and a structural unit derived from a hydrophilic monomer, a choline derivative, and a solvent, on the base layer.Type: ApplicationFiled: August 20, 2021Publication date: December 9, 2021Applicant: TERUMO KABUSHIKI KAISHAInventors: Hiromasa KOHAMA, Keiko KONDO
-
Publication number: 20200197576Abstract: Disclosed is a method for producing a medical instrument having a lubricating layer (a coating layer) exhibiting excellent durability (particularly, sliding durability). The method for producing a medical instrument is a method for producing a medical instrument having a base layer, and a lubricating layer that is carried on at least a part of the base layer. The method for producing a medical instrument also includes applying, to the base layer, a solution containing a block copolymer having a structural unit (A) derived from a reactive monomer having an epoxy group and a structural unit (B) derived from a hydrophilic monomer, an alkylammonium salt having 8 to 24 carbon atoms, and a solvent; and washing off the solution applied to the base layer.Type: ApplicationFiled: March 4, 2020Publication date: June 25, 2020Applicant: TERUMO KABUSHIKI KAISHAInventor: Hiromasa KOHAMA
-
Patent number: 10376614Abstract: A medical device and a method of manufacturing the same which excels in lubricity under severe conditions are provided. The medical device according to the present disclosure is inserted into a living body. The medical device includes a resin coating layer that includes a maleic acid polymer substance and is provided on a surface of a base member. The resin coating layer is formed by covalently bonding the maleic acid polymer substance to a reactive functional group which exists on at least the surface of the base member of the medical device. A ratio of a peak height of carboxylate with respect to a total peak height of carboxylic acid ester and a carboxylic acid in the maleic acid polymer substance ranges from 1.2 to 1.7 when being measured through infrared spectroscopy (IR method).Type: GrantFiled: March 2, 2016Date of Patent: August 13, 2019Assignee: TERUMO KABUSHIKI KAISHAInventors: Hiromasa Kohama, Ayako Tokue
-
Patent number: 10098988Abstract: A medical device includes a base layer, and a lubrication layer supported on at least a part of the base layer, wherein the lubrication layer contains a block copolymer (A) composed of a first constituting unit derived from a reactive monomer that has an epoxy group and a second constituting unit derived from at least one hydrophilic monomer selected from the group consisting of acrylamide and an acrylamide derivative, and a polymer (B) composed of a constituting unit derived from at least one hydrophilic monomer selected from the group consisting of acrylamide and an acrylamide derivative, wherein the block copolymer (A) is contained in a proportion of 20 to 80% by weight relative to the total weight of the block copolymer (A) and the polymer (B), and wherein the block copolymer (A) is crosslinked or polymerized to form a mesh structure.Type: GrantFiled: May 23, 2017Date of Patent: October 16, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Hiromasa Kohama, Ayako Tokue
-
Publication number: 20170258966Abstract: A medical device includes a base layer, and a lubrication layer supported on at least a part of the base layer, wherein the lubrication layer contains a block copolymer (A) composed of a first constituting unit derived from a reactive monomer that has an epoxy group and a second constituting unit derived from at least one hydrophilic monomer selected from the group consisting of acrylamide and an acrylamide derivative, and a polymer (B) composed of a constituting unit derived from at least one hydrophilic monomer selected from the group consisting of acrylamide and an acrylamide derivative, wherein the block copolymer (A) is contained in a proportion of 20 to 80% by weight relative to the total weight of the block copolymer (A) and the polymer (B), and wherein the block copolymer (A) is crosslinked or polymerized to form a mesh structure.Type: ApplicationFiled: May 23, 2017Publication date: September 14, 2017Applicant: TERUMO KABUSHIKI KAISHAInventors: Hiromasa KOHAMA, Ayako TOKUE
-
Patent number: 9523001Abstract: A means for restraining hardening of silicone rubber is provided. In one form, a silicone rubber composition is provided that contains an antioxidant dispersed therein. In addition, a method for preparing the silicone rubber composition is provided that includes: a step of mixing a silicone rubber precursor and the antioxidant and curing the obtained mixture; or a step of wetting the silicone rubber with a liquid antioxidant. A method of manufacturing a medical device is also provided, including: a step of incorporating into a medical device the silicone rubber composition obtained in the preparation method outlined above; a step of seal packaging the obtained medical device; and a step of irradiating the seal-packaged medical device with radiation.Type: GrantFiled: March 13, 2013Date of Patent: December 20, 2016Assignee: TERUMO KABUSHIKI KAISHAInventors: Hiromasa Kohama, Makoto Onishi, Yuki Souma
-
Publication number: 20160175492Abstract: A medical device and a method of manufacturing the same which excels in lubricity under severe conditions are provided. The medical device according to the present disclosure is inserted into a living body. The medical device includes a resin coating layer that includes a maleic acid polymer substance and is provided on a surface of a base member. The resin coating layer is formed by covalently bonding the maleic acid polymer substance to a reactive functional group which exists on at least the surface of the base member of the medical device. A ratio of a peak height of carboxylate with respect to a total peak height of carboxylic acid ester and a carboxylic acid in the maleic acid polymer substance ranges from 1.2 to 1.7 when being measured through infrared spectroscopy (IR method).Type: ApplicationFiled: March 2, 2016Publication date: June 23, 2016Applicant: TERUMO KABUSHIKI KAISHAInventors: Hiromasa Kohama, Ayako Tokue
-
Patent number: 9205232Abstract: A balloon for catheter of the type that has a film body that is inflatable and deflatable using a fluid supplied from a catheter, the film body including a hard layer containing a polyamide and a flexible layer formed on the hard layer and containing a polyamide elastomer having a Shore D hardness that is not larger than 62, and the content of the amide units of the polyamide elastomer in the flexible layer is not less than 60 wt %.Type: GrantFiled: July 20, 2012Date of Patent: December 8, 2015Assignee: TERUMO KABUSHIKI KAISHAInventors: Hideaki Kiminami, Hiromasa Kohama
-
Publication number: 20140171347Abstract: A medical device of which the surface exhibits lubricity and/or antithrombotic activity when wet. The medical device includes a base material layer, and a hydrophilic layer that is supported on at least a portion of the base material layer, in which the hydrophilic layer is obtained by forming a crosslinked structure by reacting a compound having plural thiol groups in a molecule with a compound having reactive functional groups binding to the thiol group and hydrophilic groups in a molecule, and the reactive functional groups are thiol groups, alkenyl groups, acryl groups, or methacryl groups.Type: ApplicationFiled: February 21, 2014Publication date: June 19, 2014Applicant: TERUMO KABUSHIKI KAISHAInventors: Hiromasa Kohama, Kenichi Shimura, Satoshi Sawada
-
Publication number: 20130085519Abstract: A balloon for catheter of the type that has a film body that is inflatable and deflatable by means of a fluid supplied from a catheter, the film body including a hard layer containing a polyamide and a flexible layer formed on the hard layer and containing a polyamide elastomer having a Shore D hardness that is not larger than 62, and the content of the amide units of the polyamide elastomer in the flexible layer is not less than 60 wt %Type: ApplicationFiled: July 20, 2012Publication date: April 4, 2013Applicant: TERUMO KABUSHIKI KAISHAInventors: Hideaki KIMINAMI, Hiromasa KOHAMA
-
Patent number: 8278397Abstract: Disclosed are a medical instrument and a medical material each comprising an aliphatic polyester resin composition, which are hardly reduced in strength and impact resistance upon the sterilization by ionizing radiation or have excellent shape-retaining properties after a heat treatment. Specifically, a medical instrument and a medical material both sterilized by ionizing radiation are provided, each of which contains a biodegradable resin and a polycarbodiimide compound in an amount of 0.1 to 10% by weight on the resin. The biodegradable resin is polybutylene succinate, a copolymer of polybutylene succinate, or a mixture of polybutylene succinate and a copolymer of polybutylene succinate with polylactic acid or poly(3-hydroxyalkanoate). A method of producing such medical instrument and medical material is also provided.Type: GrantFiled: March 23, 2009Date of Patent: October 2, 2012Assignee: Terumo Kabushiki KaishaInventor: Hiromasa Kohama
-
Patent number: 8038658Abstract: A medical needle is made of a synthetic resin which is reinforced, including the point part of the needle, to reduce deformation during puncture, even when the needle is produced by injection molding. The needle is made of a synthetic resin composition which includes synthetic resin and reinforcing fiber having a length of 80 ?m or below and reinforcing fiber having a length exceeding 80 ?m. The number ratio of the former fiber to the whole fiber component is 40% to 90%. A synthetic resin composition for needles includes a synthetic resin and a reinforcing fiber component, wherein the composition is prepared by adding at least two kinds of fibers, namely a fiber having a mean length of 1 mm to 10 mm and a fiber having a mean length of 10 ?m to 100 ?m to the synthetic resin and kneading the obtained mixture.Type: GrantFiled: September 21, 2006Date of Patent: October 18, 2011Assignee: Terumo Kabushiki KaishaInventor: Hiromasa Kohama
-
Publication number: 20110213102Abstract: A medical device and medical material using an aromatic biodegradable resin composition, which is not susceptible to decrease in strength and impact resistance during sterilization by ionizing radiation. Provided are ionizing radiation sterilized medical device and medical material, which contain a composition composed of an aromatic polyester-based biodegradable resin and a polylactic acid, with the polylactic acid being 25 to 70 wt % of the weight of the composition. The medical device and medical material are biodegradable, while having excellent strength and impact resistance.Type: ApplicationFiled: March 29, 2011Publication date: September 1, 2011Applicant: TERUMO KABUSHIKI KAISHAInventors: Hiromasa KOHAMA, Hideaki KIMINAMI
-
Publication number: 20110054065Abstract: Disclosed are a medical instrument and a medical material each comprising an aliphatic polyester resin composition, which are hardly reduced in strength and impact resistance upon the sterilization by ionizing radiation or have excellent shape-retaining properties after a heat treatment. Specifically, a medical instrument and a medical material both sterilized by ionizing radiation are provided, each of which contains a biodegradable resin and a polycarbodiimide compound in an amount of 0.1 to 10% by weight on the resin. The biodegradable resin is polybutylene succinate, a copolymer of polybutylene succinate, or a mixture of polybutylene succinate and a copolymer of polybutylene succinate with polylactic acid or poly(3-hydroxyalkanoate). A method of producing such medical instrument and medical material is also provided.Type: ApplicationFiled: March 23, 2009Publication date: March 3, 2011Applicant: TERUMO KABUSHIKI KAISHAInventor: Hiromasa Kohama
-
Publication number: 20090312480Abstract: A medical needle is made of a synthetic resin which is reinforced, including the point part of the needle, to reduce deformation during puncture, even when the needle is produced by injection molding. The needle is made of a synthetic resin composition which includes synthetic resin and reinforcing fiber having a length of 80 ?m or below and reinforcing fiber having a length exceeding 80 ?m. The number ratio of the former fiber to the whole fiber component is 40% to 90%. A synthetic resin composition for needles includes a synthetic resin and a reinforcing fiber component, wherein the composition is prepared by adding at least two kinds of fibers, namely a fiber having a mean length of 1 mm to 10 mm and a fiber having a mean length of 10 ?m to 100 ?m to the synthetic resin and kneading the obtained mixture.Type: ApplicationFiled: September 21, 2006Publication date: December 17, 2009Applicant: Terumo Kabushiki DaishaInventor: Hiromasa Kohama
-
Patent number: 5789595Abstract: The present invention relates to a tetrahydroisoquinoline derivative represented by the following formula 1 exhibiting an inhibitory action for agglutination caused by fibrinogen, which may be effectively used as an antithrombotic agent or a platelet agglutination-inhibiting agent. The present invention also relates to a medical preparation containing such compound. ##STR1## In formula 1, B and G are an alkylene optionally substituted with an alkyl or the like; D is H, an alkyl, or the like; E is 1,2,3,4-tetrahydroisoquinoline optionally substituted with R.sub.1 to R.sub.4 which binds to G at position 2; R.sub.1 to R.sub.4 are an alkyl or the like; L is hydroxy or the like; and A is a substituent represented by formula (2), and C is carbon. ##STR2## In formula 2, M and R.sub.5 to R.sub.8 are H, an alkyl or the like.Type: GrantFiled: July 21, 1997Date of Patent: August 4, 1998Assignee: Terumo Kabushiki KaishaInventors: Hiromasa Kohama, Nobuyuki Nakata, Masahiro Suzuki, Youko Terajima
-
Patent number: 5155106Abstract: A cysteamine derivative represented by general formula (I): ##STR1## wherein R.sub.1 represents a straight-chain or a branched alkyl radical having 1 to 6 carbon atoms, R.sub.2 represents hydrogen atom or n-propyl radical, and X represents a radical selected from the group consisting of radicals containing cysteamine moiety (N S) represented by formula (II): ##STR2## formula (III): ##STR3## formula (IV): ##STR4## formula (V): ##STR5## or formula (VI): ##STR6## wherein R.sub.2 represents hydrogen atom or a straight-chain or a branched alkyl group having 1 to 10 carbon atoms is provided.The cysteamine derivative is effective as an antirheumatic agent.Type: GrantFiled: July 20, 1990Date of Patent: October 13, 1992Assignee: Terumo Kabushiki KaishaInventors: Masaki Shimizu, Shingo Koyama, Hiromasa Kohama, Ryoichi Nanba, Kazuhito Inoue