Patents by Inventor Hiromasa Miyaji

Hiromasa Miyaji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating cancer using a chimera antibody
    Patent number: 5807548
    Abstract: A humanized chimera antibody, a process for its production and methods for its use are disclosed. The chimera antibody is produced without changing any amino acids of its mouse antibody variable region.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 15, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kenya Shitara, Nobuo Hanai, Mamoru Hasegawa, Hiromasa Miyaji, Yoshihisa Kuwana
  • Polypeptide derivatives of human granulocyte colony stimulating factor
    Patent number: 5795968
    Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
    Type: Grant
    Filed: January 10, 1997
    Date of Patent: August 18, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
  • Process for producing humanized chimera antibody
    Patent number: 5750078
    Abstract: A humanized chimera antibody, a pharmaceutical composition comprising a humanized chimera antibody and a pharmaceutically acceptable carrier, and a method of treating cancer which comprises administering to a patient a pharmaceutically acceptable amount of said humanized chimera antibody, are disclosed.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: May 12, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kenya Shitara, Nobuo Hanai, Mamoru Hasegawa, Hiromasa Miyaji, Yoshihisa Kuwana
  • Polypeptide derivatives of human granulocyte colony stimulating factor
    Patent number: 5714581
    Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: February 3, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
  • DNA encoding human granulocyte colony stimulating factor plasmids and host cells comprising same, and methods of expressing the encoded polypeptide
    Patent number: 5681720
    Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: October 28, 1997
    Assignee: Kyowa Hakko Co., Ltd.
    Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
  • Polypeptide derivatives of human granulocyte colony stimulating factor
    Patent number: 5362853
    Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: November 8, 1994
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Yoshinori Komatsu
  • Polypeptide derivatives of human granulocyte colony stimulating factor
    Patent number: 5214132
    Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: May 25, 1993
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
  • Novel human interleukin-2 polypeptide derivative
    Patent number: 4851512
    Abstract: Novel human IL-2 polypeptide derivatives characterized by deletion of at least one amino acid from the amino acid sequence of the human IL-2 polypeptide, recombinant plasmids containing DNAs coding for the above derivatives, microorganisms harboring these plasmids and methods of producing the above derivatives in these microorganisms are provided.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: July 25, 1989
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hiromasa Miyaji, Seiga Itoh