Patents by Inventor Hiromasa Oka

Hiromasa Oka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Azole compound
    Patent number: 8207199
    Abstract: A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that an azole compound substituted with an N-(pyridine-3-yl)oxycarbonyl-piperidin-4-yl group and a phenyl group or a pharmaceutically acceptable salt thereof has an excellent FAAH inhibitory activity, thereby completing the present invention. The compound of the present invention is confirmed to have an excellent FAAH inhibitory activity and an antiallodynic effect in rat models with neuropathic pain, and thus is useful as an agent for preventing and/or an agent for treating neuropathic pain.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: June 26, 2012
    Assignee: Astellas Pharma Inc.
    Inventors: Satoshi Aoki, Ryosuke Munakata, Noriyuki Kawano, Kiyohiro Samizu, Hiromasa Oka, Takahiro Ishii, Takashi Sugane
  • AZOLE COMPOUND
    Publication number: 20110118311
    Abstract: A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that an azole compound substituted with an N-(pyridine-3-yl)oxycarbonyl-piperidin-4-yl group and a phenyl group or a pharmaceutically acceptable salt thereof has an excellent FAAH inhibitory activity, thereby completing the present invention. The compound of the present invention is confirmed to have an excellent FAAH inhibitory activity and an antiallodynic effect in rat models with neuropathic pain, and thus is useful as an agent for preventing and/or an agent for treating neuropathic pain.
    Type: Application
    Filed: July 13, 2009
    Publication date: May 19, 2011
    Inventors: Satoshi Aoki, Ryosuke Munakata, Noriyuki Kawano, Kiyohiro Samizu, Hiromasa Oka, Takahiro Ishii, Takashi Sugane