Abstract: New therapeutic agent of carboxymethylidenecycloheptimidazole derivatives and method for the manufacture thereof are disclosed, which are represented by the following formula or its alkali addition salts ##STR1## (wherein R.sub.1 represents a lower alkyl; R.sub.2 represents H or isopropyl group; R.sub.3 represent H, a lower alkyl or --C(CH.sub.3)H--OCOOR.sub.4 (R.sub.4 is a lower alkyl or cyclohexyl) and .dbd.CHCOOR.sub.3 is substituted group at 4 or 8 position; A represents ##STR2## These compounds are useful as anti-hypertensive, anti-congestive heart failure agents and intraocular pressure lowering agents.

Abstract: New therapeutic agents of cycloheptimidazole derivatives are disclosed, which are represented by the following formula or its alkali-addition salts. ##STR1## (wherein R.sub.1 represents H or isopropyl group; R.sub.2 represents a lower alkyl; R.sub.3 represents a carboxylic acid or tetrazole group. A and A.sub.1 are substituted groups at 4 or 8 position and A.sub.1 is a hydrogen or hydroxy group when A is a hydrogen or A and A.sub.1 is an oxo group. The dotted line "- - - -" is two double bonds or saturated single bonds).These compounds are useful as anti-hypertensive or anti-congestive heart failure agents.

Abstract: An absorbent article including a liquid permeable outer material, a liquid impermeable antileakage material, and a liquid retentive absorbent element interposed therebetween, and formed in a generally vertically elongated shape, the improvement including a pair of fixing elements extending outwardly in a width direction from both longitudinal edges of the absorbent article, each of the fixing element being provided on at least a back side thereof with a first adhesive portion having no separate paper, the pair of fixing elements being able to be adhered to and separated from a back side of the absorbent article through the first adhesive portions.

Abstract: In an absorbent article including a liquid permeable outer material, a liquid impermeable antileakage material, a liquid retentive absorbent element interposed therebetween, and a fixing device mounted on a back side of a generally vertically elongated absorbent article body and adapted to fix the body to a crotch portion of shorts, the fixing device has a pair of fixing elements, each of the fixing elements extending outwardly in a width direction from each lateral edge of the absorbent article body, the fixing element being provided on at least a back side thereof with an adhesive portion, the pair of fixing elements being able to be adhered to and separated from a back side of the absorbent article body through the adhesive portions.