Patents by Inventor Hiromi Okigami

Hiromi Okigami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC OR PREVENTIVE AGENT FOR EYE DISEASES
    Publication number: 20240041883
    Abstract: Because 3-[(3S, 4R)-3-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile suppresses an increase of the retinal vascular permeability induced by VEGF, it can be used as an active ingredient of a therapeutic or preventive agent for various eye diseases involving VEGF, such as age-related macular degeneration, diabetic retinopathy, macular edema, neovascular maculopathy, retinal vein occlusion and neovascular glaucoma.
    Type: Application
    Filed: February 17, 2023
    Publication date: February 8, 2024
    Inventors: Hiromi Okigami, Tatsuji Kurose, Koushi Fujisawa, Chinami Kikkawa
  • Therapeutic Agent for Ocular Disease or Prophylactic Agent for Ocular Disease
    Publication number: 20160367556
    Abstract: Because 3-[(3S, 4R)-3-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile suppresses an increase of the retinal vascular permeability induced by VEGF, it can be used as an active ingredient of a therapeutic or preventive agent for various eye diseases involving VEGF, such as age-related macular degeneration, diabetic retinopathy, macular edema, neovascular maculopathy, retinal vein occlusion and neovascular glaucoma.
    Type: Application
    Filed: October 17, 2014
    Publication date: December 22, 2016
    Inventors: Hiromi OKIGAMI, Tatsuji KUROSE, Koushi FUJISAWA, Chinami KIKKAWA
  • Beta-amino acid derivatives as integrin receptor antagonists
    Patent number: 7091242
    Abstract: The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.
    Type: Grant
    Filed: October 8, 2001
    Date of Patent: August 15, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Rölle, Thomas Lehmann, Markus Albers, Gerhard Hessler, Gerhard Müller, Rüdiger Fischer, Masaomi Tajimi, Karl Ziegelbauer, Kevin Bacon, Haruki Hasegawa, Hiromi Okigami
  • Succinic acid derivatives
    Patent number: 7064229
    Abstract: The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: June 20, 2006
    Assignee: Bayer Healthcare AG
    Inventors: Thomas Rolle, Thomas Lehmann, Markus Albers, Gerhard Muller, Gerhard Hessler, Rudiger Fischer, Masaomi Tajimi, Karl Ziegelbauer, Kevin Bacon, Haruki Hasegawa, Hiromi Okigami
  • Para-amino benzoic acids as integrin antagonists
    Publication number: 20050054582
    Abstract: The present invention relates to compounds of the general formula (I), their preparation and use as pharmaceutical compositions asintegrin antagonists, especially as ?4? and/or ?4?7 ?and/or ?9?1 intergrin antagonists and in particular for the production of pharmaceutical compositions suitable for the inhibition or the prevention of cell adhesion and cell-adhesion mediated disorders. Examples are the treatment and the prophylaxis of atherosclerosis, asthma, chronic obstructive pulmonary disease (COPD), allergies, diabetes, inflammatory bowel disease, multiple sclerosis, myocardial ischemia, rheumatoid arthritis, transplant rejection and other inflammatory, autoimmune and immune disorders.
    Type: Application
    Filed: September 20, 2002
    Publication date: March 10, 2005
    Inventors: Thomas Lehmann, Markus Albers, Thomas Rolle, Gerhard Hessler, Gerhard Hessler, Masaomi Tajimi, Karl Ziegelbauer, Hiromi Okigami, Kevin Bacon, Haruki Hasegawa
  • Succinic acid derivatives
    Publication number: 20040254157
    Abstract: The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.
    Type: Application
    Filed: August 4, 2004
    Publication date: December 16, 2004
    Inventors: Thomas Rlle, Thomas Lehmann, Markus Albers, Gerhard Muller, Gerhard Hessler, Rudiger Fischer, Masaomi Tajimi, Karl Ziegelbauer, Kevin Bacon, Haruki Hasegawa, Hiromi Okigami
  • Beta-amino acid compounds as integrin antagonists
    Publication number: 20040229859
    Abstract: The present invention relates to compounds of the general formula (I), 1
    Type: Application
    Filed: May 28, 2004
    Publication date: November 18, 2004
    Applicant: Bayer Aktiengesellschaft
    Inventors: Markus Albers, Thomas Lehmann, Thomas Rolle, Gerhard Muller, Gerhard Hessler, Masaomi Tajimi, Karl Ziegelbauer, Hiromi Okigami, Haruki Hasegawa
  • &bgr;-amino acid compounds as integrin antagonists
    Patent number: 6794386
    Abstract: The present invention relates to a compound of the general formula (I), wherein R1 together with the C atom to which it is attached, and R2 together with the N atom to which it is attached, form a piperidinyl ring; X represents a bond, oxygen or —NR12—; and Y represents oxygen; pharmaceutical compositions containing such a compound, as well as the use of such a compound for the production of pharmaceutical compositions, and for the treatment of inflammatory, auto-immune and immune diseases.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: September 21, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Markus Albers, Thomas Lehmann, Thomas Rölle, Gerhard Müller, Gerhard Hessler, Masaomi Tajimi, Karl Ziegelbauer, Hiromi Okigami, Haruki Hasegawa
  • Regulation of human chemokine-like receptor
    Publication number: 20040076985
    Abstract: Reagents which regulate human chemokine-like receptor and reagents which bind to human chemokine-like receptor gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, HIV infection, cardiovascular disorders, asthma and COPD.
    Type: Application
    Filed: October 27, 2003
    Publication date: April 22, 2004
    Inventors: Alex Smolyar, Zhimin Zhu, Jeffrey Encinas, Shinichi Watanabe, Hiromi Okigami
  • Beta-amino acid derivatives as integrin receptor antagonists
    Publication number: 20040058904
    Abstract: The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.
    Type: Application
    Filed: September 29, 2003
    Publication date: March 25, 2004
    Inventors: Thomas Rolle, Thomas Lehmann, Markus Albers, Gerhard Hebler, Gerhard Muller, Rudiger Fischer, Masaomi Tajimi, Karl Ziegelbauer, Kevin Bacon, Haruki Hasegawa, Hiromi Okigami
  • Beta-amino acid compounds as integrin antagonists
    Publication number: 20040029883
    Abstract: The present invention relates to compounds of general formula (I), wherein the residues R represent organic radicals, X represents a bond, oxygen or —NR12 and Y represents oxygen or sulfur, processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory, autoimmune and immune diseases.
    Type: Application
    Filed: November 19, 2002
    Publication date: February 12, 2004
    Inventors: Markus Albers, Thomas Lehmann, Thomas Rlle, Gerhard Mller, Gerhard Hessler, Masaomi Tajimi, Karl Ziegelbauer, Hiromi Okigami, Haruki Hasegawa
  • Cyclic carboxylic acids as integrin antagonists
    Publication number: 20030232868
    Abstract: The present invention relates to compounds of general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.
    Type: Application
    Filed: May 12, 2003
    Publication date: December 18, 2003
    Inventors: Thomas Lehmann, Rudiger Fischer, Markus Albers, Thomas Rolle, Gerhard Muller, Gerhard Hessler, Masaomi Tajimi, Karl Ziegelbauer, Hiromi Okigami, Kevin Bacon, Haruki Hasegawa