Abstract: A cannulation method includes inserting an endoscope into a duodenum, bringing a distal end section of the endoscope to a position where a duodenal papilla is within a field of view of the endoscope, promoting secretion of pancreatic juice or bile by administering a drainage stimulant, determining an amount of relaxation of the duodenal papilla, and performing cannulation into a biliary duct through the duodenal papilla where the amount of relaxation is greater than a predetermined amount.

Abstract: The purpose of the present invention is to provide a method for evaluating the possibility of suffering from pancreatic disease on the basis of the concentration of a pancreatic disease marker in a duodenal juice sample. The method for evaluating the possibility of suffering from pancreatic disease of the present invention has a step for (a) measuring the concentration of the pancreatic disease marker in a duodenal juice sample taken from a subject and a step for (b) evaluating the possibility of the subject suffering from pancreatic disease on the basis of the concentration of the pancreatic disease marker measured in step (a) and the age of the subject.

Abstract: The purpose of the present invention is to provide a method for evaluating the possibility of suffering from pancreatic disease on the basis of the concentration of a pancreatic disease marker in a duodenal juice sample. The method for evaluating the possibility of suffering from pancreatic disease of the present invention has a step for (a) measuring the concentration of the pancreatic disease marker in a duodenal juice sample taken from a subject and a step for (b) evaluating the possibility of the subject suffering from pancreatic disease on the basis of the concentration of the pancreatic disease marker measured in step (a) and the age of the subject.

Abstract: A method for collecting tissue includes a body fluid removal step in which a body fluid inside a pancreatic cyst is moved to an outside of the pancreatic cyst, an injecting step in which a liquid different from the body fluid is injected into the pancreatic cyst, a collecting step in which the liquid is collected from the pancreatic cyst, and a separating step in which tissue of an inner wall of the pancreatic cyst, which is contained in the liquid collected from the pancreatic cyst, is separated from the liquid.

Abstract: A method of determining pancreatic disease of the present invention is a method of determining whether an IPMN patient has pancreatic disease, the method including: a first step of measuring a concentration of S100P in duodenal juice of the IPMN patient; and a second step of determining the IPMN patient is a malignant IPMN patient or a pancreatic cancer patient when the concentration of the S100P is equal to or greater than a predetermined cutoff value, and the IPMN patient is a benign IPMN patient when the concentration of the S100P is smaller than the predetermined cutoff value.

Abstract: The present invention provides a method for preserving biological components in pancreatic juice, and a kit suited for this method. The method involves adding, to a pancreatic juice-containing biological sample, at least one sulfonyl fluoride-containing protease inhibitor and at least one trypsin-like serine protease inhibitor belonging to a group of amino acid chloromethyl ketones.

Abstract: Provided are a method for exclusively selecting a duodenal fluid sample having a high possibility of containing pancreatic fluid and favorable sample suitability for subjecting to detection of a pancreatic disease marker by evaluating the quality of the sample prior to detecting the pancreatic disease marker, and a method for detecting a pancreatic disease marker using a duodenal fluid sample selected according to that method. Namely, a method is provided for selecting a duodenal fluid sample for detecting a pancreatic disease marker, comprising: (a1) a step of comparing the color depth of a duodenal fluid sample with a prescribed standard color, and (b1) a step of determining that a duodenal fluid sample is subjected to a test for a pancreatic disease marker if the color depth thereof is equal to or higher than the standard color, but that the duodenal fluid sample is not subjected to a test for a pancreatic disease marker if the color depth thereof is lower than the standard color.

Abstract: A pancreatic disease is tested for with high sensitivity even with simple equipment and a simple procedure. Provided is a method of detecting pancreatic disease including detecting a concentration of S100P in at least one of a pancreatic juice and a body fluid containing pancreatic juice collected from a test subject by immunochromatography. Additionally provided is a pancreas testing kit including an immunochromatography device that holds an anti-S100P antibody and a collection vessel that retains a protease inhibitor that inhibits an activity of a protease contained in the pancreatic juice.

Abstract: The present invention provides a method for preserving biological components in pancreatic juice, and a kit suited for this method. The method involves adding, to a pancreatic juice-containing biological sample, at least one sulfonyl fluoride-containing protease inhibitor and at least one trypsin-like serine protease inhibitor belonging to a group of amino acid chloromethyl ketones.

Abstract: The present invention relates to a method for detecting a marker for pancreatic disease for obtaining highly reliable results while reducing the risk of complications. It also relates to a method for a detecting a marker for pancreatic disease comprising: measuring the concentration of a marker for pancreatic disease in duodenal juice that is collected from a subject and contains spontaneously discharged pancreatic juice, by a measurement method including detecting antigen or antibody immobilized on a solid phase using an antigen-antibody reaction, and the aforementioned method for detecting a marker for pancreatic disease further including judging the subject to have the possibility of being afflicted with a pancreatic disease in the case the concentration of the marker for pancreatic disease is equal to or greater than a prescribed threshold value.

Abstract: A pancreatic disease is tested for with high sensitivity even with simple equipment and a simple procedure. Provided is a method of detecting pancreatic disease including detecting a concentration of S100P in at least one of a pancreatic juice and a body fluid containing pancreatic juice collected from a test subject by immunochromatography. Additionally provided is a pancreas testing kit including an immunochromatography device that holds an anti-S100P antibody and a collection vessel that retains a protease inhibitor that inhibits an activity of a protease contained in the pancreatic juice.

Abstract: A method of collecting a specimen of the present invention is used in detecting upper digestive system disease. The method of collecting a specimen includes: a step of positioning sampling equipment in the duodenum of the subject into which duodenal juice is secreted, the sampling equipment being used to collect and store the duodenal juice; a step of collecting duodenal juice naturally secreted in the duodenum using the sampling equipment; and a step of stopping collection of the duodenal juice when collection quantity of the duodenal juice reaches a predetermined quantity which is 3.0 ml or less.

Abstract: A method of collecting a specimen of the present invention detects upper digestive system disease. The method of collecting a specimen includes: a step of administering a stimulant of pancreatic juice secretion or a stimulant of bile secretion to a subject; a step of positioning sampling equipment in the duodenum of the subject into which duodenal juice is secreted, the sampling equipment being used to collect and store the duodenal juice; a step of starting collection of the duodenal juice by the sampling equipment within five minutes from the administration of the stimulant of pancreatic juice secretion or the stimulant of bile secretion; and a step of stopping collection of the duodenal juice such that collection time for the duodenal juice is within five minutes from the start of collection.

Abstract: A method of collecting a specimen of the present invention is used in detecting upper digestive system disease. The method of collecting a specimen includes: a step of positioning sampling equipment in the duodenum of the subject into which duodenal juice is secreted, the sampling equipment being used to collect and store the duodenal juice; a step of collecting duodenal juice naturally secreted in the duodenum using the sampling equipment; and a step of stopping collection of the duodenal juice when collection quantity of the duodenal juice reaches a predetermined quantity which is 3.0 ml or less.

Abstract: A method of collecting a specimen of the present invention detects upper digestive system disease. The method of collecting a specimen includes: a step of administering a stimulant of pancreatic juice secretion or a stimulant of bile secretion to a subject; a step of positioning sampling equipment in the duodenum of the subject into which duodenal juice is secreted, the sampling equipment being used to collect and store the duodenal juice; a step of starting collection of the duodenal juice by the sampling equipment within five minutes from the administration of the stimulant of pancreatic juice secretion or the stimulant of bile secretion; and a step of stopping collection of the duodenal juice such that collection time for the duodenal juice is within five minutes from the start of collection.

Abstract: A display method of measurement information of a biologically relevant material according to the invention displays measurement information on a computer screen when measuring the amount of a biologically relevant material of a test sample or the amount ratio of a biologically relevant material among a plurality of test samples with a microarray.

Abstract: A living-tissue sampling instrument includes a hollow tubular member having a sampling part configured to sample living tissues at a distal end of the tubular member, and a suction mechanism configured to draw the living tissue sampled by the sampling part at a proximal end of the tubular member. Projections extending inwards are provided on least one part of the inner circumferential surface of the tubular member.

Abstract: An object of the invention is to provide a quick, easy, and highly-sensitive method of detecting a substance to be analyzed, and to provide a method of supporting the analysis results by quantitativeness even if the amount of samples to be handled is a very small amount. The invention is a method of detecting a substance to be analyzed, including: measuring a intensity of a signal derived from a labeled substance to be analyzed, in a time series during an increase in the signal intensity; and representing the signal intensity by a function of time, and using the quantitative value of the signal intensity for when the slope of an approximated line of the measured signal intensity is within a range between 0.5 and 1.5 times the slope of the approximated line of the previously measured signal intensity.

Abstract: A biopsy device includes an catching member that is able to catch and release a living sample, a sheath through which the catching member is able to be inserted, and a container that stores the living sample. The container includes a container portion that is able to contain a sample preservation reagent and the living sample, a first removable insertion portion connected detachably and liquid-tightly to an end portion of the sheath, through which the catching member is able to be removably inserted from an outside of the container to the container portion, and a second removable insertion portion through which the catching member is able to be removably inserted from the container portion to an outside of the container in a liquid-tight manner.