Patents by Inventor Hiromichi Murai

Hiromichi Murai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230190854
    Abstract: A method of reducing muscle damage in a human being includes providing an extract of Kenyan purple tea (scientific name: Camellia sinensis; variety name: TRFK306) containing 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-?-D-glucose (GHG). Then, an effective amount of the purple tea extract is administered to a body of a human being engaged in intensive exercise to reduce muscle damage associated with the intensive exercise.
    Type: Application
    Filed: February 9, 2023
    Publication date: June 22, 2023
    Inventors: Hiroshi SHIMODA, Hiromichi MURAI
  • Publication number: 20220370539
    Abstract: A 5?-reductase inhibitor contains saw palmetto extract and seaberry extract as an active ingredient in a synergistic compounding ratio, wherein the compounding ratio by weight of the saw palmetto extract and the seaberry extract is 3:1˜2. The 5?-reductase inhibitor containing the saw palmetto extract and seaberry extract or just the seaberry extract as a 5?-reductase inhibitor can be administered to the human body in order to inhibit 5?-reductase. The 5?-reductase inhibitor is useful as a prostate enlargement inhibitor, an androgenic alopecia inhibitor, and an acne prevention and amelioration agent. The 5?-reductase inhibitor can be part of a food or drink composition or a cosmetic composition.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 24, 2022
    Inventors: Kenchi MIYASAKA, Norihito SHIMIZU, Hiroshi SHIMODA, Hiromichi MURAI
  • Patent number: 11478495
    Abstract: An AMP-activated protein kinase (AMPK) activating agent comprises 1,2-di-O-galloyl-4,6-O—(S)-hexahydroxydiphenoyl-b-D-glucose (“GHG”) as an active ingredient. The AMPK activating agent can be a GHG-containing composition wherein the GHG is an active ingredient of the composition. The GHG-containing composition can be derived from Kenyan purple tea, whose scientific name is Camellia sinensis, variety name: TRFK306. An effective amount of the GHG can be administered to a cell to activate the AMPK. Drinks, foods, and cosmetics can have the GHG as an active ingredient.
    Type: Grant
    Filed: November 10, 2019
    Date of Patent: October 25, 2022
    Assignee: ORYZA OIL & FAT CHEMICAL CO., LTD.
    Inventors: Toru Takarada, Hiroshi Shimoda, Hiromichi Murai
  • Publication number: 20210228673
    Abstract: A method of promoting NO-production in a human being includes providing an extract of Kenyan purple tea (scientific name: Camellia sinensis; variety name: TRFK306) containing 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-?-D-glucose (GHG). Then, an effective amount of the purple tea extract is administered to a body of a human being in need of NO-production promotion.
    Type: Application
    Filed: January 7, 2021
    Publication date: July 29, 2021
    Inventors: Hiroshi SHIMODA, Hiromichi MURAI
  • Patent number: 11033566
    Abstract: This invention provides a prophylactic and therapeutic agent for dry eye, having new ingredients to reduce the deterioration of the lacrimal secretory ability and to inhibit the generation of radical oxygen in lacrimal gland tissue. The prophylactic and therapeutic agent for dry eye of this invention contains the maqui berry extract as the active substance of this invention, i.e. containing delphinidin glycoside extracted from the maqui berry and at least one or more of the active substances delphinidin-3-sambubioside-5-glucoside, delphinidin-3,5-diglucoside, delphinidin-3-sambubioside and delphinidin-3-glucoside, preferably delphinidin-3,5-diglucoside.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: June 15, 2021
    Assignees: ORYZA OIL & FAT CHEMICAL CO., LTD., KEIO UNIVERSITY
    Inventors: Kazuo Tsubota, Shigeru Nakamura, Toshihiro Imada, Junji Tanaka, Takashi Kadekaru, Hiroshi Shimoda, Hiromichi Murai
  • Publication number: 20210096077
    Abstract: A weak light detection system includes an excitation light radiator that irradiates a test piece with excitation light in an excitation light radiation pattern modulated by an error correction code sequence provided by applying an error correction code coding scheme to a predetermined transmitted information sequence, a light receiver that receives light stimulated by the excitation light at the test piece, a received code sequence identifier that identifies a received code sequence based on a change in the intensity of the light received by the light receiver, and a signal processor that applies an error correction code decoding scheme to the received code sequence to generate a decoded information sequence, compares the transmitted information sequence with the decoded information sequence, and determines that the test piece has emitted light according to the excitation light radiation pattern in a case where the transmitted information sequence coincides with the decoded information sequence.
    Type: Application
    Filed: November 27, 2018
    Publication date: April 1, 2021
    Applicant: PHOTO MEDICAL LIMITED LIABILITY COMPANY
    Inventors: Hiromichi MURAI, Takashi YAMAMOTO
  • Publication number: 20200360338
    Abstract: A method for activating energy metabolism in muscle cells by administering to human beings at least one active substance comprising methoxyflavone for energy metabolism activation, the at least one active substance shown in the following Chemical Formula 1, wherein for Chemical Formula 1, R1 means an alkyl group with the number of carbons being 1 and R2 is hydrogen, and neither the B-ring nor the C-ring of the flavone skeleton has a substituent The active substance can be part of a composition of food.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 19, 2020
    Inventors: Kazuya TODA, Shogo TAKEDA, Hiroshi SHIMODA, Hiromichi MURAI
  • Publication number: 20190343858
    Abstract: This invention provides a new application to 1,2-di-O-galloyl-4,6-O—(S)-hexahydroxydiphenoyl-ß-D-glucose (i.e. GHG) that is contained in Kenyan purple tea (scientific name: Camellia sinensis; variety name: TRFK306), as well as a new circadian-rhythm regulator that can be widely used in medicines, foods and drinks, and cosmetics. The circadian-rhythm regulator of this invention is characterized in containing the GHG as an active ingredient for promoting the BMAL1 gene-expression. Also, the circadian-rhythm regulator of this invention is characterized in containing the GHG-content extract derived from Kenyan purple tea as an active ingredient for promoting the BMAL1 gene-expression.
    Type: Application
    Filed: January 30, 2017
    Publication date: November 14, 2019
    Inventors: Hiroshi SHIMODA, Marina KOHATSU, Kazuya TODA, Hiromichi MURAI
  • Publication number: 20190328701
    Abstract: A method for activating metabolism for muscle cells involves administering an energy-metabolic activating agent to a human patient, the energy-metabolic activing agent as follows: (1) a sugar transporter (GLUT4) gene-expression promoting agent, including at least one active substance selected from the following: 5-hydroxy-3,7-dimethoxyflavone; techtochrysin; 3,7,4?-trimethylkaempferol; retusine; pentamethyiquercetin; trimethylapigenin; tetramethylkaempferol; and 5, 7-dimethoxyflavone, (2) a sugar transporter (GLUT4) gene-expression promoting agent, including at least one active substance selected from either techtochrysin or 5,7-dimethoxyflavone, and (3) a sugar transporter (GLUT4) gene-expression promoting agent within the muscle cells that includes any one of the chemical compounds shown in the following chemical formula 1. (Of such formula 1, R1 and R2, respectively, mean an alkyl group with hydrogen or with 1˜3-carbon.
    Type: Application
    Filed: July 8, 2019
    Publication date: October 31, 2019
    Inventors: Kazuya TODA, Shogo TAKEDA, Hiroshi SHIMODA, Hiromichi MURAI
  • Publication number: 20180117000
    Abstract: This invention provides a new energy-metabolic activating agent for muscle cells and provides compounds that are widely used in foods and drinks and in medicines and in quasi-drugs or the like. The technical features of this invention are as follows: (1) A sugar transporter (GLUT4) gene-expression promoting agent, including at least one active substance selected from the following: 5-hydroxy-3,7-dimethoxyflavone; techtochrysin; 3,7,4?-trimethylkaempferol; retusine; pentamethylquercetin; trimethylapigenin; tetramethylkaempferol; and 5,7-dimethoxyflavone, (2) A sugar transporter (GLUT4) gene-expression promoting agent, including at least one active substance selected from either techtochrysin or 5,7-dimethoxyflavone, and (3) A sugar transporter (GLUT4) gene-expression promoting agent within the muscle cells that includes any one of the chemical compounds shown in the following chemical formula 1. (Of such formula 1, R1 and R2, respectively, mean an alkyl group with hydrogen or with 1˜3-carbon.
    Type: Application
    Filed: March 24, 2016
    Publication date: May 3, 2018
    Inventors: Kazuya TODA, Shogo TAKEDA, Hiroshi SHIMODA, Hiromichi MURAI
  • Publication number: 20180036328
    Abstract: This invention provides a prophylactic and therapeutic agent for dry eye, having new ingredients to reduce the deterioration of the lacrimal secretory ability and to inhibit the generation of radical oxygen in lacrimal gland tissue. The prophylactic and therapeutic agent for dry eye of this invention contains the maqui berry extract as the active substance of this invention, i.e. containing delphinidin glycoside extracted from the maqui berry and at least one or more of the active substances delphinidin-3-sambubioside-5-glucoside, delphinidin-3,5-diglucoside, delphinidin-3-sambubioside and delphinidin-3-glucoside, preferably delphinidin-3,5-diglucoside.
    Type: Application
    Filed: October 5, 2017
    Publication date: February 8, 2018
    Inventors: Kazuo TSUBOTA, Shigeru Nakamura, Toshihiro Imada, Junji Tanaka, Takashi Kadekaru, Hiroshi Shimoda, Hiromichi Murai
  • Patent number: 9381223
    Abstract: Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains en extract of cherry tree (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active substance. The AGE production inhibitor or the like contains, as an active substance, at least one compound that is selected from among 1-O-(E)-Caffeoyl-?-D-glucopyranoside, 1-O-(E)-Coumaroyl-?-D-glucopyranoside, 1-O-(E)-Cinnamoyl-?-D-glucopyranoside, Kaempferol 3-O-?-D-glucopyranoside, Quercetin 3-O-?-D-glucopyranoside, Kaempferol 3-O-(6?-malony)-?-D-glucopyranoside, and Quercetin 3-O-(6?-malony)-?-D-glucopyranoside.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: July 5, 2016
    Assignee: ORYZA OIL & FAT CHEMICAL CO., LTD.
    Inventors: Hiroshi Shimoda, Takashi Watanabe, Hiromichi Murai, Masayuki Yoshikawa
  • Publication number: 20150359812
    Abstract: This invention provides a prophylactic and therapeutic agent for dry eye, having new ingredients to reduce the deterioration of the lacrimal secretory ability and to inhibit the generation of radical oxygen in lacrimal gland tissue. The prophylactic and therapeutic agent for dry eye of this invention contains the maqui berry extract as the active substance of this invention, i.e. containing delphinidin glycoside extracted from the maqui berry and at least one or more of the active substances delphinidin-3-sambubioside-5-glucoside, delphinidin-3,5-diglucoside, delphinidin-3-sambubioside and delphinidin-3-glucoside, preferably delphinidin-3,5-diglucoside.
    Type: Application
    Filed: December 17, 2013
    Publication date: December 17, 2015
    Inventors: Kazuo TSUBOTA, Shigeru NAKAMURA, Toshihiro IMADA, Junji TANAKA, Takashi KADEKARU, Hiroshi SHIMODA, Hiromichi MURAI
  • Publication number: 20150174188
    Abstract: Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains en extract of cherry tree (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active substance. The AGE production inhibitor or the like contains, as an active substance, at least one compound that is selected from among 1-O-(E)-Caffeoyl-?-D-glucopyranoside, 1-O-(E)-Coumaroyl-?-D-glucopyranoside, 1-O-(E)-Cinnamoyl-?-D-glucopyranoside, Kaempferol 3-O-?-D-glucopyranoside, Quercetin 3-O-?-D-glucopyranoside, Kaempferol 3-O-(6?-malony)-?-D-glucopyranoside, and Quercetin 3-O-(6?-malony)-?-D-glucopyranoside.
    Type: Application
    Filed: March 26, 2014
    Publication date: June 25, 2015
    Inventors: Hiroshi SHIMODA, Takashi Watanabe, Hiromichi Murai, Masayuki Yoshikawa
  • Patent number: 8802164
    Abstract: (PROBLEMS) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes. (MEANS FOR SOLVING PROBLEMS) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt/wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: August 12, 2014
    Assignee: Oryza Oil & Fat Chemical Co., Ltd.
    Inventors: Hiroshi Shimoda, Michio Aitani, Tomoko Sugishita, Tadashi Okada, Hiromichi Murai, Emi Yamada
  • Publication number: 20130196937
    Abstract: Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains en extract of cherry tree (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active substance. The AGE production inhibitor or the like contains, as an active substance, at least one compound that is selected from among 1-O-(E)-Caffeoyl-?-D-glucopyranoside, 1-O-(E)-Coumaroyl-?-D-glucopyranoside, 1-O-(E)-Cinnamoyl-?-D-glucopyranoside, Kaempferol 3-O-?-D-glucopyranoside, Quercetin 3-O-?-D-glucopyranoside, Kaempferol 3-O-(6?-malony)-?-D-glucopyranoside, and Quercetin 3-O-(6?-malony)-?-D-glucopyranoside.
    Type: Application
    Filed: February 10, 2011
    Publication date: August 1, 2013
    Applicant: ORYZA OIL & FAT CHEMICAL CO., LTD.
    Inventors: Hiroshi Shimoda, Takashi Watanabe, Hiromichi Murai, Masayuki Yoshikawa
  • Patent number: 8017162
    Abstract: This invention provides an anti-inflammatory agent or the like which is safer and less adverse and has the great effectiveness to prevent and treat arthritis, or the like. An anti-inflammatory agent or the like in this invention is characterized by comprising anthocyanidin and gingerol as an active substance. Also, the abovementioned anthocyanidin and gingerol are preferably extracted from red ginger.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: September 13, 2011
    Assignee: Oryza Oil & Fat Chemical Co., Ltd.
    Inventors: Hiroshi Shimoda, Shaojie Shan, Junji Tanaka, Tadashi Okada, Hiromichi Murai
  • Publication number: 20110189313
    Abstract: (Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes. (Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt/wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia.
    Type: Application
    Filed: March 2, 2011
    Publication date: August 4, 2011
    Applicant: ORYZA OIL & FAT CHEMICAL CO., LTD.
    Inventors: Hiroshi SHIMODA, Michio AITANI, Tomoko SUGISHITA, Tadashi OKADA, Hiromichi MURAI, Emi YAMADA
  • Publication number: 20100208231
    Abstract: Object is to provide a light wave distance measuring system and a light wave distance measuring device which are capable of realizing prolonged measurable distance as well as improved distance measuring accuracy and which enable a distance measuring device to be constructed inexpensively.
    Type: Application
    Filed: March 14, 2008
    Publication date: August 19, 2010
    Inventor: Hiromichi Murai
  • Publication number: 20090274777
    Abstract: (Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes. (Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt/wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia.
    Type: Application
    Filed: October 5, 2004
    Publication date: November 5, 2009
    Inventors: Hiroshi Shimoda, Michio Aitani, Tomoko Sugishita, Tadashi Okada, Hiromichi Murai, Emi Yamada