Patents by Inventor Hiromitsu Nakauchi

Hiromitsu Nakauchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210032595
    Abstract: According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.
    Type: Application
    Filed: August 12, 2020
    Publication date: February 4, 2021
    Inventors: Hiromitsu NAKAUCHI, Shin KANEKO, Toshinobu NISHIMURA
  • Publication number: 20200315146
    Abstract: The present invention provides a method for preparing a somatic chimera by using a pluripotent cell genetically engineered not to differentiate into a predetermined type of cell. The present invention particularly provides a method for preventing a pluripotent cell from contributing to the brain and gonad in a somatic chimera animal.
    Type: Application
    Filed: October 9, 2018
    Publication date: October 8, 2020
    Applicant: The University of Tokyo
    Inventors: Hiromitsu NAKAUCHI, Hideyuki SATO, Hideki MASAKI, Motoo WATANABE
  • Publication number: 20200315148
    Abstract: The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 8, 2020
    Applicants: THE UNIVERSITY OF TOKYO, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Hiromitsu NAKAUCHI, Hideki MASAKI, Motoo WATANABE, Irving WEISSMAN
  • Patent number: 10787642
    Abstract: According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: September 29, 2020
    Assignee: The University of Tokyo
    Inventors: Hiromitsu Nakauchi, Shin Kaneko, Toshinobu Nishimura
  • Patent number: 10645912
    Abstract: [Problem to be Solved] The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. [Solution] The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: May 12, 2020
    Assignees: THE UNIVERSITY OF TOKYO, THE BOARD OF REGENTS OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Hiromitsu Nakauchi, Hideki Masaki, Motoo Watanabe, Irving Weissman
  • Publication number: 20200137991
    Abstract: The present invention has found that chimeric animals suffer from noticeable inflammation after birth, though neither immune response nor inflammation in the fetal period of these animals has been reported hitherto. This is an unexpected finding since chimeric animals in the fetal period were exclusively analyzed in prior studies and thus it is deemed that immunotolerance has been theoretically established therein. The present invention provides a composition for suppressing immune response or inflammation in the fetal period of a born chimeric animal.
    Type: Application
    Filed: January 25, 2018
    Publication date: May 7, 2020
    Inventors: Hiromitsu NAKAUCHI, Tomoyuki YAMAGUCHI, Sanae HAMANAKA, Hideyuki SATO, Hideki MASAKI, Naoaki MIZUNO, Motoo WATANABE
  • Patent number: 10533185
    Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: January 14, 2020
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Hiromitsu Nakauchi, Naoya Takayama, Sou Nakamura
  • Publication number: 20200008404
    Abstract: An object of the present invention is to produce a mammalian organ having a complicated cellular composition composed of multiple kinds of cells, such as kidney, pancreas, thymus and hair, in the living body of a non-human animal. The inventors of the present invention applied the chimeric animal assay described above, to a novel solid organ production method. More specifically, the inventors has shown that a model mouse which is deficient of kidney, pancreas, thymus or hair due to the dysfunction of the metanephric mesenchyme that is differentiated into most of an adult kidney, is rescued by blastocyst complementation by the chimeric animal assay, and whereby a kidney, a pancreas, thymus or hair can be newly produced.
    Type: Application
    Filed: March 18, 2019
    Publication date: January 9, 2020
    Inventors: Hiromitsu Nakauchi, Toshihiro Kobayashi, Younsu Lee, Joichi Usui, Tomoyuki Yamaguchi, Sanae Hamanaka
  • Publication number: 20190282602
    Abstract: An object of the present invention is to provide a method which constantly enables organ regeneration for the purpose of achieving organ regeneration with higher efficiency. It has been discovered that, in a blastocyst complementation method, a next generation is born when a deficiency in an organ, such as pancreas and kidney, is complemented by injection of ES cells into a generated blastocyst, and further discovered that a transgenic animal having a pancreas or a kidney thus complemented can transmit the phenotype to the next generation as a founder. This discovery has revealed that organ regeneration can be accomplished by using such a founder. Thus, the present invention achieved the above-described object.
    Type: Application
    Filed: March 25, 2019
    Publication date: September 19, 2019
    Inventors: Hiromitsu NAKAUCHI, Toshihiro KOBAYASHI
  • Publication number: 20190269638
    Abstract: A nutrition formulation, which is substantially free of at least one of valine and methionine and which is capable of parenteral or enteral administration. The nutrition formulation supplies sufficient nutrients to sustain life for at least three weeks by successive administration. A composition containing the nutrition formulation can be used for treating adult cell leukemiallymphoma.
    Type: Application
    Filed: August 4, 2017
    Publication date: September 5, 2019
    Applicant: The University of Tokyo
    Inventors: Hiromitsu NAKAUCHI, Tomohiro ISHIGAKI, Satoshi YAMAZAKI, Yuki TAYA
  • Patent number: 10383836
    Abstract: Problem to be Solved The present invention provides a technique replacing radiation exposure in decreasing or eliminating hematopoietic stem cells in an animal (particularly human) body. Solution A parenteral nutrition formula or an enteral nutrition formula substantially free of valine.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: August 20, 2019
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Hiromitsu Nakauchi, Satoshi Yamazaki, Yuki Taya
  • Publication number: 20190133093
    Abstract: It is revealed that an organ such as pancreas can be regenerated by utilizing a fact that the deficiency of an organ is complemented by injecting an induced pluripotent stem cell (iPS cell) into a developed blastocyst in a blastocyst complementation method. Thus, the present invention has solved the above-described object. This provides a method for producing a target organ, using an iPS cell, in a living body of a non-human mammal having an abnormality associated with a lack of development of the target organ in a development stage, the target organ produced being derived from a different individual mammal that is an individual different from the non-human mammal.
    Type: Application
    Filed: November 15, 2018
    Publication date: May 9, 2019
    Inventors: Hiromitsu NAKAUCHI, Toshihiro KOBAYASHI, Tomoyuki YAMAGUCHI, Sanae HAMANAKA
  • Patent number: 10246679
    Abstract: The present invention provides a method for putting a primed pluripotent stem cell in a less differentiated state, a method for producing a pluripotent stem cell having an improved chimera forming ability from a primed pluripotent stem cell, and a method for producing a chimeric animal by using the pluripotent stem cell obtained by any of these methods. The present invention also provides a composition containing a Wnt/? catenin signal inhibitor.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: April 2, 2019
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Hiromitsu Nakauchi, Hideki Masaki, Hideyuki Murayama
  • Publication number: 20180360004
    Abstract: [Problem to be Solved] The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. [Solution] The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell.
    Type: Application
    Filed: January 17, 2018
    Publication date: December 20, 2018
    Applicants: THE UNIVERSITY OF TOKYO, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Hiromitsu Nakauchi, Hideki Masaki, Motoo Watanabe, Irving Weissman
  • Patent number: 10087419
    Abstract: The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: October 2, 2018
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi
  • Publication number: 20180177164
    Abstract: The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal, such as a human, at a high percentage is sustained for a long period of time, even in cases where a medium to large domestic animal is used as a recipient. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified. The gene that acts on the hematopoietic system is, for example, Lnk gene.
    Type: Application
    Filed: June 20, 2016
    Publication date: June 28, 2018
    Applicants: National Federation of Agricultural Cooperative Associations, The University of Tokyo
    Inventors: Kazuo FUKAWA, Tetsuya ITO, Mai KAMIKAWA, Yutaka SENDAI, Hiromitsu NAKAUCHI, Satoshi YAMAZAKI, Motoo WATANABE
  • Publication number: 20180016597
    Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
    Type: Application
    Filed: August 18, 2017
    Publication date: January 18, 2018
    Applicant: The University of Tokyo
    Inventors: Koji Eto, Hiromitsu Nakauchi, Naoya Takayama, Sou Nakamura
  • Publication number: 20170354626
    Abstract: Problem to be Solved The present invention provides a technique replacing radiation exposure in decreasing or eliminating hematopoietic stem cells in an animal (particularly human) body. Solution A parenteral nutrition formula or an enteral nutrition formula substantially free of valine.
    Type: Application
    Filed: November 25, 2015
    Publication date: December 14, 2017
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Hiromitsu NAKAUCHI, Satoshi YAMAZAKI, Yuki TAYA
  • Publication number: 20170280692
    Abstract: An object of the present invention is to produce a mammalian organ having a complicated cellular composition composed of multiple kinds of cells, such as kidney, pancreas, thymus and hair, in the living body of a non-human animal. The inventors of the present invention applied the chimeric animal assay described above, to a novel solid organ production method. More specifically, the inventors has shown that a model mouse which is deficient of kidney, pancreas, thymus or hair due to the dysfunction of the metanephric mesenchyme that is differentiated into most of an adult kidney, is rescued by blastocyst complementation by the chimeric animal assay, and whereby a kidney, a pancreas, thymus or hair can be newly produced.
    Type: Application
    Filed: December 12, 2016
    Publication date: October 5, 2017
    Inventors: Hiromitsu NAKAUCHI, Toshihiro KOBAYASHI, Younsu LEE, Joichi USUI, Tomoyuki YAMAGUCHI, Sanae HAMANAKA
  • Patent number: 9738906
    Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: August 22, 2017
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Hiromitsu Nakauchi, Naoya Takayama, Sou Nakamura