Abstract: A server may include: a memory; and a controller, wherein the controller may be configured to: execute a registering process, wherein in the registering process, the controller may receive usage information from a terminal device and store the usage information in the memory, and the usage information may include a first attribute inputted to the terminal device by a user; and execute a starting process, wherein in the starting process, the controller may receive from the terminal device specific information and determine whether the first attribute matches a second attribute of a specific function executing device identified by the specific information and execute a service process for starting a provision of the service to the user using the usage information stored in the memory in a case where it is determined that the first attribute matches the second attribute.

Abstract: A food inspection apparatus includes: a conveyance unit; a light irradiation unit; an unit capturing an image of an inspection object A; a wavelength emphasis emphasizing a foreign substance specific wavelength characteristic of a foreign substance F from light having a wavelength of 300 nm to 1100 nm by using a first and/or second optical filter or a wavelength-specific light source; and an identification processing device identifying the foreign substance and including: a lightening unit normalizing the captured image with 256 or less of gradations into lightened data; and an identification unit having been provided with deep-learning of an identification processing of the foreign substance specific wavelength from the lightened data and identifying the foreign substance or a good item S in line from the lightened data obtained through capturing the image during conveyance of the inspection object.

Abstract: A food inspection apparatus 1 includes: a conveyance unit 2; a light irradiation unit 3; an imaging unit 4 capturing an image of an inspection object A; a wavelength emphasis unit 5 emphasizing a foreign substance specific wavelength characteristic of a foreign substance F from light having a wavelength of 300 nm to 1100 nm by using a first and/or second optical filter 51, 52 or a wavelength-specific light source; and an identification processing device 6 identifying the foreign substance and including: a lightening unit 61 normalizing the captured image with 256 or less of gradations into lightened data; and an identification unit 62 having been provided with deep-learning of an identification processing of the foreign substance specific wavelength from the lightened data and identifying the foreign substance or a good item S in line from the lightened data obtained through capturing the image during conveyance of the inspection object.

Abstract: A clip—for a fuel injection valve includes a load transmitting member—and a fitting member. The load transmitting member is formed from a single wire material and includes a contacting portion, which contacts a contactable surface formed in the fuel injection valve, a depressible portion, which is depressible in a downward direction by a pressing surface formed in a fuel supply conduit, and a spring portion, which is formed between one end of the contacting portion and the depressible portion and is resiliently deformable by a load. The fitting member-is formed separately from the load transmitting member and is connected to the load transmitting member on a side of the contacting portion, which is opposite from the spring portion. The fitting member is fittable to a fittable portion of the fuel supply conduit.

Abstract: A clip for a fuel injection valve is formed by one wire member bent at a plurality of parts, and includes a contact part that contacts with a contacted surface formed on a fuel injection valve; a pressed part pressed in a downward direction by a pressing surface formed on a fuel supply pipe; a spring part formed between one end of the contact part and the pressed part and deformed by load in the downward direction received by the pressed part and transmitting the load in the downward direction to the contact part; and a rotation stopping part extended in an upward direction from an end part of the contact part opposite to the spring part and fitting with a rotation stopping fitting part of the fuel supply pipe. Since the spring part, the pressed part, and the rotation stopping part are connected to the respective end parts of the contact part opposite to each other, a stress is hardly transmitted to the rotation stopping part when the pressed part is pressed.

Abstract: A clip-for a fuel injection valve includes a load transmitting member-and a fitting member. The load transmitting member is formed from a single wire material and includes a contacting portion, which contacts a contactable surface formed in the fuel injection valve, a depressible portion, which is depressible in a downward direction by a pressing surface formed in a fuel supply conduit, and a spring portion, which is formed between one end of the contacting portion and the depressible portion and is resiliently deformable by a load. The fitting member-is formed separately from the load transmitting member and is connected to the load transmitting member on a side of the contacting portion, which is opposite from the spring portion. The fitting member is fittable to a fittable portion of the fuel supply conduit.

Abstract: The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.

Abstract: Provided are: a method for detecting bladder cancer with high detection sensitivity, which has a high specificity for bladder cancer and is capable of detecting bladder cancer tissues with low grade of malignancy; and a bladder cancer marker. A method for detecting bladder cancer cells, which comprises detection of the amount of expressed bladder cancer marker in a subject sample collected from a subject, said bladder cancer marker being composed of one or more miRNAs selected from among miR-124, miR-9 and miR-137; a primer which is used in the method for detecting bladder cancer cells; and a bladder cancer marker.

Abstract: The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.

Abstract: The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.

Abstract: A method of identifying epigenetically silenced genes, e.g., methylation silenced genes, in cancer cells is provided. In addition, methods of identifying a cancer by detecting epigenetic silencing of gene expression are provided, as are methods of treating a subject having such a cancer, for example, a colorectal cancer and/or gastric cancer. Reagents for practicing such methods also are provided.

Abstract: Methods of genomic screening to identify epigenetically silenced genes, including epigenetically silenced tumor suppressor genes are provided. Also provided are methods of detecting a cancer, for example, an esophageal squamous cell carcinoma or a head and neck squamous cell carcinoma, as are methods of treating a subject having such a cancer.

Abstract: A method of identifying epigenetically silenced genes, e.g., methylation silenced genes, in cancer cells is provided. In addition, methods of identifying a cancer by detecting epigenetic silencing of gene expression are provided, as are methods of treating a subject having such a cancer, for example, a colorectal cancer and/or gastric cancer. Reagents for practicing such methods also are provided.

Abstract: A genome wide microarray gene expression approach for human colorectal cancer cells was used to identify hundreds of hypermethylated genes for colon cancer. We compared isogenic cells altered pharmacologically versus genetically to induce genomic demethylation, to pinpoint genes activated by DNA demethylation, but not by inhibition of class I and II histone deacetylases (HDACs). We achieve an 82% success rate in predicting genes with densely hypermethylated CpG islands and complete gene silencing. The genes are similarly hypermethylated in primary tumors and have previously undetected tumor suppressor functions. The genes can be used diagnostically to detect cancer, pre-cancer, and likelihood of developing cancer.

Abstract: A method of identifying epigenetically silenced genes, e.g., methylation silenced genes, in cancer cells is provided. In addition, methods of identifying a cancer by detecting epigenetic silencing of gene expression are provided, as are methods of treating a subject having such a cancer, for example, a colorectal cancer and/or gastric cancer. Reagents for practicing such methods also are provided.