Patents by Inventor Hironobu Isogawa
Hironobu Isogawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230158505Abstract: A specimen collection container is provided, the specimen collection container being capable of suppressing a change in a mixing ratio of a specimen collected to a liquid contained even when a long period of time has elapsed after manufacturing. A specimen collection container according to the present invention is a specimen collection container into which a specimen is collected, the specimen collection container including: a container main body having an opening; a plug attached to the opening; a barrier film disposed on an outer surface of the container main body; and a liquid contained in the container main body, the barrier film having a water vapor transmission rate at 40° C. and 90% RH of 0.8 g/(m2·day) or less.Type: ApplicationFiled: March 23, 2021Publication date: May 25, 2023Applicants: SEKISUI MEDICAL CO., LTD., TOKUYAMA SEKISUI CO., LTD.Inventors: Takaya UCHIYAMA, Kuniya KOMAI, Masatoshi NIUNOYA, Yuuki GOTOU, Hironobu ISOGAWA
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Publication number: 20230133626Abstract: Provided is a storage container for cell-containing solutions, which makes it possible to enhance the storage stability of cfDNA contained in a cell-containing solution even when the cell-containing solution is stored under a room temperature environment. The storage container for cell-containing solutions according to the present invention is intended to be used for storing a predetermined amount of a cell-containing solution, the storage container being provided with a container main body and a preservative solution contained in the container main body, in which the storage container has a first configuration such that the preservative solution contains a cell-membrane-permeable compound that has a molecular weight of 100 or less and cannot be frozen at 0° C.Type: ApplicationFiled: March 3, 2021Publication date: May 4, 2023Applicants: SEKISUI MEDICAL CO., LTD., TOKUYAMA SEKISUI CO., LTD.Inventors: Yuuki GOTOU, Hironobu ISOGAWA, Takaya UCHIYAMA, Tomonori INOUE
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Publication number: 20230090675Abstract: Provided is a blood collection container with which a specimen with a high leukocyte recovery rate and a small amount of contaminating erythrocytes can be obtained. A blood collection container according to the present invention is a blood collection container by which a predetermined amount of blood is collected, the blood collection container including: a blood collection container main body; and a hemocyte separation material contained in the blood collection container main body, the hemocyte separation material having a specific gravity at 25° C. of 1.075 or more and 1.Type: ApplicationFiled: March 11, 2021Publication date: March 23, 2023Applicants: SEKISUI MEDICAL CO., LTD., TOKUYAMA SEKISUI CO., LTD.Inventors: Kuniya KOMAI, Hironobu ISOGAWA
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Publication number: 20230050815Abstract: Provide is a blood collection container capable of suppressing the occurrence of blood clots involving bubbles when blood containing heparin is coagulated, and capable of suppressing the production of fibrin in serum after separation when blood containing heparin is separated into serum and blood clots. A blood collection container according to the present invention includes: a blood collection container main body having an opening at one end thereof and a closed bottom at the other end thereof; a serine protease disposed in the blood collection container main body; and a heparin neutralizing agent disposed in the blood collection container main body, wherein when a region in which the serine protease is disposed is defined as a first region, and a region in which the heparin neutralizing agent is disposed is defined as a second region, the second region includes a region present on an other end side with respect to an end on the other end side of the first region.Type: ApplicationFiled: November 30, 2020Publication date: February 16, 2023Applicants: SEKISUI MEDICAL CO., LTD., TOKUYAMA SEKISUI CO., LTD.Inventors: Yuji SETOGUCHI, Hironobu ISOGAWA
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Publication number: 20220226752Abstract: Provided is a composition for mononuclear cell-containing plasma separation capable of suppressing a flow of the composition for mononuclear cell-containing plasma separation during storage, capable of satisfactorily forming a partition during centrifugation, and capable of yielding mononuclear cell-containing plasma with little admixture of blood cell components other than mononuclear cells. The composition for mononuclear cell-containing plasma separation according to the present invention contains an organic component having fluidity at 25° C. and two or more kinds of inorganic fine powders, and has a specific gravity of 1.060 or more and 1.080 or less at 25° C.Type: ApplicationFiled: May 19, 2020Publication date: July 21, 2022Applicants: SEKISUI MEDICAL CO., LTD., TOKUYAMA SEKISUI CO., LTDInventors: Kuniya KOMAI, Hironobu ISOGAWA, Hideo ANRAKU
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Patent number: 8685713Abstract: The present invention relates to a blood testing bottomed tube, which comprises a tubular member having an open one end and closed another end, and a coating layer formed on at least a part to be contacted with blood on said tubular member, said coating layer being made of a polyoxyalkylene alkyl ether or a polyoxyalkylene glycol ether, the present invention also relates to a stopper for a blood testing bottom tube and a blood testing container.Type: GrantFiled: July 7, 2008Date of Patent: April 1, 2014Assignee: Sekisui Chemical Co., Ltd.Inventors: Masaaki Minamoto, Hironobu Isogawa
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Patent number: 8586323Abstract: The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability; and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom.Type: GrantFiled: April 21, 2004Date of Patent: November 19, 2013Assignee: Sekisui Chemical Co., Ltd.Inventors: Ryusuke Okamoto, Katsuya Togawa, Hironobu Isogawa
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Patent number: 7993847Abstract: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.Type: GrantFiled: December 7, 2006Date of Patent: August 9, 2011Assignees: Sekisui Medical Co., Ltd., Nittobo Medical Co., Ltd., Toyo Boseki Kabushiki KaishaInventors: Katsuya Togawa, Ryusuke Okamoto, Hironobu Isogawa
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Patent number: 7927810Abstract: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.Type: GrantFiled: November 18, 2003Date of Patent: April 19, 2011Inventors: Katsuya Togawa, Ryusuke Okamoto, Hironobu Isogawa
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Publication number: 20100248329Abstract: The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability, and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom.Type: ApplicationFiled: April 9, 2010Publication date: September 30, 2010Inventors: Ryusuke Okamoto, Katsuya Togawa, Hironobu Isogawa
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Patent number: 7767466Abstract: A method for filtrating liquid sample such as blood or the like with a filter member utilizing inner vacuum, the same enabling completion of filtration without removing a stopper, and superior in safety and being free from contamination. In collecting and filtrating the liquid sample using a sample collection vessel 1, in which a sample-collecting part 3 containing a filter member 4 is inserted in a vacuumed sample-storing part 2, the sample storing part 2 and sample-collecting part 3 are air-tightly sealed with a stopper 5, the liquid sample such as blood or the like collected in the sample-collecting part 3 is filtrated by the filter member 4. When the filtration stops, a hollow needle 12 is pierced through the stopper 5 and thus the sample-collecting part 3 is communicated with atmosphere, thereby the pressure in the sample-collecting part 3 being enhanced upper than in atmosphere to enable the filtration again.Type: GrantFiled: April 22, 2004Date of Patent: August 3, 2010Assignees: Sekisui Medical Co., Ltd., I-Design Co., Ltd., Nittobo Medical Co., Ltd.Inventors: Katsuya Togawa, Hironobu Isogawa
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Patent number: 7744820Abstract: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.Type: GrantFiled: December 7, 2006Date of Patent: June 29, 2010Inventors: Katsuya Togawa, Ryusuke Okamoto, Hironobu Isogawa
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Patent number: 7595028Abstract: The present invention relates to a blood testing bottomed tube, which comprises a tubular member having an open one end and closed another end, and a coating layer formed on at least a part to be contacted with blood on said tubular member, said coating layer being made of a polyoxyalkylene alkyl ether and/or a polyoxyalkylene glycol ether; the present invention also relates to a stopper for a blood testing bottomed tube and a blood testing container.Type: GrantFiled: May 29, 2003Date of Patent: September 29, 2009Assignee: Sekisui Chemical Co., Ltd.Inventors: Masaaki Minamoto, Hironobu Isogawa
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Publication number: 20080274540Abstract: The present invention relates to a blood testing bottomed tube, which comprises a tubular member having an open one end and closed another end, and a coating layer formed on at least a part to be contacted with blood on said tubular member, said coating layer being made of a polyoxyalkylene alkyl ether or a polyoxyalkylene glycol ether, the present invention also relates to a stopper for a blood testing bottom tube and a blood testing container.Type: ApplicationFiled: July 7, 2008Publication date: November 6, 2008Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Masaaki Minamoto, Hironobu Isogawa
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Publication number: 20070105156Abstract: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.Type: ApplicationFiled: December 7, 2006Publication date: May 10, 2007Inventors: Katsuya Togawa, Ryusuke Okamoto, Hironobu Isogawa
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Publication number: 20070082370Abstract: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.Type: ApplicationFiled: December 7, 2006Publication date: April 12, 2007Inventors: Katsuya Togawa, Ryusuke Okamoto, Hironobu Isogawa
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Publication number: 20060199275Abstract: A method for filtrating liquid sample such as blood or the like with a filter member utilizing inner vacuum, the same enabling completion of filtration without removing a stopper, and superior in safety and being free from contamination. In collecting and filtrating the liquid sample using a sample collection vessel 1, in which a sample-collecting part 3 containing a filter member 4 is inserted in a vacuumed sample-storing part 2, the sample storing part 2 and sample-collecting part 3 are air-tightly sealed with a stopper 5, the liquid sample such as blood or the like collected in the sample-collecting part 3 is filtrated by the filter member 4. When the filtration stops, a hollow needle 12 is pierced through the stopper 5 and thus the sample-collecting part 3 is communicated with atmosphere, thereby the pressure in the sample-collecting part 3 being enhanced upper than in atmosphere to enable the filtration again.Type: ApplicationFiled: April 22, 2004Publication date: September 7, 2006Inventors: Katsuya Togawa, Hironobu Isogawa
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Publication number: 20060182663Abstract: It is intended to provide a filter for removing fibrinogen and a filter device for removing fibrinogen and a method of removing fibrinogen using the same by which a serum sample not affecting blood examination data can be quickly prepared from plasma. A filter for removing fibrinogen from plasma which is made of a fiber mass, microparticles or a porous polymer capable of adsorbing fibrinogen, has a surface area of 0.5 m2/g or larger and a porosity of 85% or lower.Type: ApplicationFiled: January 21, 2004Publication date: August 17, 2006Inventors: Yoshinori Uji, Hironobu Isogawa
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Publication number: 20060171915Abstract: The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability; and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom.Type: ApplicationFiled: April 21, 2004Publication date: August 3, 2006Inventors: Ryusuke Okamoto, Katsuya Togawa, Hironobu Isogawa
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Publication number: 20060029923Abstract: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.Type: ApplicationFiled: November 18, 2003Publication date: February 9, 2006Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Katsuya Togawa, Ryusuke Okamoto, Hironobu Isogawa