Abstract: An objective of the present invention is to provide a chemically-modified siRNA that has polydeoxyadenylic acid added to the 5? end of the sense strand, and, when complexed with schizophyllan, is high in resistance against RNase and moreover effectively exhibits RNAi activity. To achieve the objective, in the chemically-modified siRNA with polydeoxyadenylic acid added to the 5? end of the sense strand, specific chemical modification is performed for dinucleotide sequences of CA, UA, and UG in the base sequence of the sense strand and dinucleotide sequences of CA, UA, and UG in the base sequence at and after the eighth base from the 5? end of the antisense strand.

Abstract: Chemically-modified siRNA may have polydeoxyadenylic acid added to the 5? end of the sense strand thereof, wherein when complexed with schizophyllan, the chemically-modified siRNA can be highly resistant to RNase and effectively exhibit RNAi activity. Modified siRNA may have polydeoxyadenylic acid at the 5? end of the sense strand thereof, based on a particular chemical modification is applied to CA, UA, and UG dinucleotide sequences in the base sequence of the sense strand thereof, and CA, UA, and UG dinucleotide sequences in the base sequence beyond the eighth base from the 5? end of the antisense strand thereof.

Abstract: The purpose of the present invention is to provide a drug that is capable of effectively inhibiting adhesion activity, growth, and engraftment of cancer cells, using an oligodeoxynucleotide (ODN) in which phosphodiester bonds are phosphorothioated (S-configured). Adhesion activity, growth inhibitory capacity, and engraftment inhibitory capacity of cancer cells are rapidly improved as a result of S-configured ODN being formed into a composite with a polysaccharide having a ?-1,3-glucan backbone.

Abstract: An objective of the present invention is to provide a chemically-modified siRNA that has polydeoxyadenylic acid added to the 5? end of the sense strand, and, when complexed with schizophyllan, is high in resistance against RNase and moreover effectively exhibits RNAi activity. To achieve the objective, in the chemically-modified siRNA with polydeoxyadenylic acid added to the 5? end of the sense strand, specific chemical modification is performed for dinucleotide sequences of CA, UA, and UG in the base sequence of the sense strand and dinucleotide sequences of CA, UA, and UG in the base sequence at and after the eighth base from the 5? end of the antisense strand.

Abstract: A nucleic acid-antigen peptide conjugate is described that is capable of forming a complex with polysaccharides that have a ?-1,3-glucan skeleton, such as schizophyllan, and which can efficiently present the antigen peptide in an antigen-presenting cell. A conjugate bonded, via a linker added to polydeoxyadenine and a disulfide bond, to an N-terminal cysteine residue of an antigen peptide that has eight or more amino acid residues having a cysteine residue at the N-terminal is capable of forming a complex with polysaccharides that have a ?-1,3-glucan skeleton, and can efficiently present the antigen peptide in an antigen-presenting cell.

Abstract: An object of the present invention is to provide a drug and a method for effectively inducing donor-specific immune tolerance in a recipient in transplantation therapy. A complex of an siRNA for a costimulatory factor and schizophyllan is delivered to a Dectin-1 expressing cell which specifically recognizes schizophyllan to regulate the function of the Dectin-1 expressing cell, and therefore can induce immunosuppression effect as well as induce immune tolerance effectively.

Abstract: A highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA and schizophyllan to form a complex.

Abstract: {circle around (1)} A spindle motor includes a fixing portion defined by a bearing portion, a holder portion, a gap between the bearing portion and the holder portion, and an adhesive arranged in the gap. {circle around (2)} The fixing portion includes first and second protruding surfaces arranged to protrude radially from a first and a second one, respectively, of an outside surface of the bearing portion and an inside surface of the holder portion; and first and second boundary surfaces arranged to join the first and second surfaces, respectively, to the first and second protruding surfaces, respectively. {circle around (3)} At least a portion of the first boundary surface is arranged above the second boundary surface. {circle around (4)} The first and second protruding surfaces are arranged radially opposite to the second and first surfaces, respectively, with a first and a second gap, respectively, intervening therebetween.

Abstract: {circle around (1)} A spindle motor includes a fixing portion defined by a bearing portion, a holder portion, a gap between the bearing portion and the holder portion, and an adhesive arranged in the gap. {circle around (2)} The fixing portion includes first and second protruding surfaces arranged to protrude radially from a first and a second one, respectively, of an outside surface of the bearing portion and an inside surface of the holder portion; and first and second boundary surfaces arranged to join the first and second surfaces, respectively, to the first and second protruding surfaces, respectively. {circle around (3)} At least a portion of the first boundary surface is arranged above the second boundary surface. {circle around (4)} The first and second protruding surfaces are arranged radially opposite to the second and first surfaces, respectively, with a first and a second gap, respectively, intervening therebetween.

Abstract: A spindle motor includes a recording disk and a clamper. A cylindrical portion includes a first screw portion positioned in an outer circumferential portion of the cylindrical portion. The clamper includes an annular raised portion configured to be fitted in a through hole of the recording disk. An inner circumferential portion of the clamper includes a second screw portion configured to be screwed to the first screw portion. At least a portion of the second screw portion is positioned in an inner circumferential portion of the annular raised portion. Each of the first screw portion and the second screw portion includes at least one of a screw groove and a screw thread. An axial position of at least a portion of the second screw portion overlaps with an axial position of the recording disk.

Abstract: A spindle motor includes a stationary portion and a rotating portion. The stationary portion includes a shaft, a first cup portion. The first cup portion includes a circular plate member and an annular member. The rotating portion includes an annular concave portion that accommodates at least a lower end portion of the annular member. A lubricant is interposed in a gap between a surface of a stationary portion and a surface of the rotating portion. The shaft, the rotating portion, and the lubricant define a fluid dynamic pressure bearing. A connection gap that reaches an inner side of the first cup portion from an outer circumferential surface of the first cup portion is configured between the circular plate member and the annular member. At least a portion of the connection gap is filled with an adhesive.

Abstract: A spindle motor includes a recording disk and a clamper. A cylindrical portion includes a first screw portion positioned in an outer circumferential portion of the cylindrical portion. The clamper includes an annular raised portion configured to be fitted in a through hole of the recording disk. An inner circumferential portion of the clamper includes a second screw portion configured to be screwed to the first screw portion. At least a portion of the second screw portion is positioned in an inner circumferential portion of the annular raised portion. Each of the first screw portion and the second screw portion includes at least one of a screw groove and a screw thread. An axial position of at least a portion of the second screw portion overlaps with an axial position of the recording disk.

Abstract: A spindle motor includes a stationary portion and a rotating portion. The stationary portion includes a shaft, a first cup portion. The first cup portion includes a circular plate member and an annular member. The rotating portion includes an annular concave portion that accommodates at least a lower end portion of the annular member. A lubricant is interposed in a gap between a surface of a stationary portion and a surface of the rotating portion. The shaft, the rotating portion, and the lubricant define a fluid dynamic pressure bearing. A connection gap that reaches an inner side of the first cup portion from an outer circumferential surface of the first cup portion is configured between the circular plate member and the annular member. At least a portion of the connection gap is filled with an adhesive.

Abstract: An object of the present invention is to provide a drug and a method for effectively inducing donor-specific immune tolerance in a recipient in transplantation therapy. A complex of an siRNA for a costimulatory factor and schizophyllan is delivered to a Dectin-1 expressing cell which specifically recognizes schizophyllan to regulate the function of the Dectin-1 expressing cell, and therefore can induce immunosuppression effect as well as induce immune tolerance effectively.

Abstract: An object of the present invention is to provide a highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan. A nucleic acid-polysaccharide complex is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA and schizophyllan to form a complex.

Abstract: A motor includes a seal cap and a tubular portion. The seal cap includes a first seal cap lower surface which is an annular surface facing axially downward, and a second seal cap lower surface which is an annular surface facing axially downward and arranged radially outward of the first seal cap lower surface. The tubular portion includes a first tubular portion upper surface which is an annular surface arranged axially opposite to the first seal cap lower surface, and a second tubular portion upper surface which is an annular surface arranged radially outward of the first tubular portion upper surface and in contact with the second seal cap lower surface. The first tubular portion upper surface includes an oil-repellent film region covered with an oil-repellent film. A substantially annular radially extending gap is defined between the first tubular portion upper surface and the first seal cap lower surface.

Abstract: An object of the present invention is to provide a highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan. A nucleic acid-polysaccharide complex is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA and schizophyllan to form a complex.

Abstract: A spindle motor includes a base portion, a rotor hub, a stator, and a circuit board. The base portion preferably includes a through hole and is arranged to spread out radially around a central axis. The rotor hub is arranged above the base portion to rotate about the central axis. The stator is arranged above the base portion, and includes coils each including at least one lead wire. The circuit board is arranged radially outward of the through hole, and arranged on a lower surface of the base portion. The base portion includes a communicating groove arranged to join the through hole and the circuit board to each other. The at least one lead wire of the coils is arranged to pass inside the through hole and the communicating groove to be electrically connected to the circuit board. The through hole is sealed with a sealant.

Abstract: A bearing mechanism includes a shaft, a sleeve portion, a thrust portion, and a cover portion. Lubricating oil is arranged in a communicating channel in the sleeve portion, a thrust gap between the sleeve portion and the thrust portion, and a tapered gap between an outside surface of the thrust portion and the cover portion. A lower end opening of the communicating channel is defined in an outer circumferential portion of a lower surface of the sleeve portion radially outward of the thrust gap. A radially outermost portion of the thrust portion is arranged either tangent to a wall surface of the communicating channel or closer to a central axis than the wall surface. The tapered gap is arranged closer to the central axis than a radially outermost point of the wall surface. The outer circumferential portion and the cover portion define a guide gap therebetween.

Abstract: A fluid dynamic bearing mechanism includes a stationary shaft, a sleeve portion arranged to rotate with respect to the shaft, and a thrust portion including an upper end surface arranged oppose to a lower end surface of the sleeve portion. An inside surface of the thrust portion includes an inside surface contact portion arranged in contact with an outside surface of the shaft, and an inside surface lower non-contact portion spaced away from the outside surface of the shaft, and arranged to extend downward from a lower end of the inside surface contact portion. An outside surface of the thrust portion includes an outside surface inclined portion arranged in contact with an interface of a lubricating oil. The lower end of the inside surface contact portion is arranged at a level axially higher than that of a lower end of the outside surface inclined portion.