Abstract: A method for producing a rubbery polymer includes a step of preparing a mixture containing an alkyl (meth)acrylate, a hydrophobe, and an emulsifier, wherein an amount of the hydrophobe is 0.1-10 parts by mass relative to 100 parts by mass of the alkyl (meth)acrylate, and an amount of emulsifier is 0.01-1.0 part by mass relative to 100 parts by mass of the alkyl (meth)acrylate; a step of applying a shear force to the mixture to prepare a pre-emulsion, and a step of heating the pre-emulsion to polymerize the resulting mixture by miniemulsion polymerization.

Abstract: A graft copolymer (B-III) includes a rubbery polymer (A-III) that is a miniemulsion polymerization reaction product of an alkyl (meth)acrylate; and at least one monomer selected from aromatic vinyl compounds, (meth)acrylic acid esters, and vinyl cyanide compounds graft-polymerized onto the rubbery polymer (A-III).

Abstract: A method for producing a rubbery polymer includes a step of preparing a mixture containing an alkyl (meth)acrylate, a hydrophobe, and an emulsifier, wherein an amount of the hydrophobe is 0.1-10 parts by mass relative to 100 parts by mass of the alkyl (meth)acrylate, and an amount of emulsifier is 0.01-1.0 part by mass relative to 100 parts by mass of the alkyl (meth)acrylate; a step of applying a shear force to the mixture to prepare a pre-emulsion, and a step of heating the pre-emulsion to polymerize the resulting mixture by miniemulsion polymerization.

Abstract: A graft copolymer (B-III) includes a rubbery polymer (A-III) that is a miniemulsion polymerization reaction product of an alkyl (meth)acrylate; and at least one monomer selected from aromatic vinyl compounds, (meth)acrylic acid esters, and vinyl cyanide compounds graft-polymerized onto the rubbery polymer (A-III).

Abstract: A thermoplastic resin composition includes 10 to 95 parts by weight of a polycarbonate resin (A); 5 to 90 parts by weight of a graft copolymer (B); and 0 to 50 parts by weight of a copolymer (C). The graft copolymer (B) is produced by the graft polymerization of 10 to 80 parts by weight of a rubbery polymer with 20 to 90 parts by weight of a monomer component including an aromatic vinyl monomer and/or a cyanide vinyl monomer, wherein the rubbery polymer has a weight average particle size of 150 to 450 nm and also has a 10 wt % particle size of 50 to 250 nm and a 90 wt % particle size of 450 to 650 nm in a particle size cumulative weight fraction. The copolymer (C) is produced by copolymerizing an aromatic vinyl monomer, a cyanide vinyl monomer and another vinyl monomer with one another.

Abstract: A thermoplastic resin composition is highly resistant to thermal discoloration during retention in a molding process and provides molded articles excellent in fluidity, impact resistance, heat resistance, surface appearance, color reproduction properties and vibration damping properties. A thermoplastic resin composition includes 20 to 70 parts by mass of a graft copolymer (A) obtained by graft copolymerizing a vinyl monomer selected from unsaturated nitrile monomers, aromatic vinyl monomers and (meth)acrylate ester monomers, in the presence of a rubbery polymer having a volume average particle diameter of 80 to 600 nm; and 30 to 80 parts by mass of a copolymer (B) obtained by copolymerizing a vinyl monomer mixture including vinyl monomers selected from unsaturated nitrile monomers, aromatic vinyl monomers and (meth)acrylate ester monomers, the vinyl monomer mixture including styrene and ?-methylstyrene as the aromatic vinyl monomers, (total of the graft copolymer (A) and copolymer (B) is 100 parts by mass).

Abstract: Provided is a graft copolymer that has an excellent impact-resistance-imparting effect and that can provide a thermoplastic resin composition excellent in weather resistance and color developability. A graft copolymer (C) obtained by graft-polymerizing one or two or more monomers (B), which are selected from (meth)acrylic acid esters, aromatic vinyls, vinyl cyanides, N-substituted maleimides, and maleic acid, onto a composite rubber-like polymer (A), which is obtained by polymerizing a mixture (Ac) containing a polyorganosiloxane (Aa) and an acrylic acid ester (Ab) after forming a miniemulsion in water solvent. A thermoplastic resin composition that contains the graft copolymer (C) and a thermoplastic resin (D).

Abstract: A thermoplastic resin composition includes 10 to 95 parts by weight of a polycarbonate resin (A); 5 to 90 parts by weight of a graft copolymer (B); and 0 to 50 parts by weight of a copolymer (C). The graft copolymer (B) is produced by the graft polymerization of 10 to 80 parts by weight of a rubbery polymer with 20 to 90 parts by weight of a monomer component including an aromatic vinyl monomer and/or a cyanide vinyl monomer, wherein the rubbery polymer has a weight average particle size of 150 to 450 nm and also has a 10 wt % particle size of 50 to 250 nm and a 90 wt % particle size of 450 to 650 nm in a particle size cumulative weight fraction. The copolymer (C) is produced by copolymerizing an aromatic vinyl monomer, a cyanide vinyl monomer and another vinyl monomer with one another.

Abstract: A thermoplastic resin composition is highly resistant to thermal discoloration during retention in a molding process and provides molded articles excellent in fluidity, impact resistance, heat resistance, surface appearance, color reproduction properties and vibration damping properties. A thermoplastic resin composition includes 20 to 70 parts by mass of a graft copolymer (A) obtained by graft copolymerizing a vinyl monomer selected from unsaturated nitrile monomers, aromatic vinyl monomers and (meth)acrylate ester monomers, in the presence of a rubbery polymer having a volume average particle diameter of 80 to 600 nm; and 30 to 80 parts by mass of a copolymer (B) obtained by copolymerizing a vinyl monomer mixture including vinyl monomers selected from unsaturated nitrile monomers, aromatic vinyl monomers and (meth)acrylate ester monomers, the vinyl monomer mixture including styrene and ?-methylstyrene as the aromatic vinyl monomers, (total of the graft copolymer (A) and copolymer (B) is 100 parts by mass).

Abstract: An acrylic rubber graft copolymer is obtained by graft polymerizing a vinyl monomer in the presence of a rubbery polymer including acrylate ester monomer units and polyfunctional monomer units, wherein the total amount of the polyfunctional monomer units in the rubbery polymer is 0.3 to 3 parts by mass with respect to 100 parts by mass of the acrylate ester monomer units, and the polyfunctional monomer units include 30 to 95 mass % of polyfunctional monomer units having two unsaturated bonds and 5 to 70 mass % of polyfunctional monomer units having three unsaturated bonds with respect to 100 mass % of the total of the polyfunctional monomer units. A thermoplastic resin composition includes the acrylic rubber graft copolymer.

Abstract: [Object] To provide acrylic rubber graft copolymers capable of giving thermoplastic resin compositions exhibiting excellent impact resistance, rigidity and appearance, and to provide thermoplastic resin compositions including the acrylic rubber graft copolymers. [Solution] An acrylic rubber graft copolymer is obtained by graft polymerizing a vinyl monomer in the presence of a rubbery polymer including acrylate ester monomer units and polyfunctional monomer units, wherein the total amount of the polyfunctional monomer units in the rubbery polymer is 0.3 to 3 parts by mass with respect to 100 parts by mass of the acrylate ester monomer units, and the polyfunctional monomer units include 30 to 95 mass % of polyfunctional monomer units having two unsaturated bonds and 5 to 70 mass % of polyfunctional monomer units having three unsaturated bonds with respect to 100 mass % of the total of the polyfunctional monomer units. A thermoplastic resin composition includes the acrylic rubber graft copolymer.

Abstract: The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.

Abstract: An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.

Abstract: The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.

Abstract: An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group -Z-R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.