Patents by Inventor Hiroo Hoshino
Hiroo Hoshino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6596720Abstract: The present invention provides: an anti-HIV composition comprising at least one member selected from the group consisting of trifluridine and derivatives thereof, and a pharmaceutically acceptable carrier; an anti-HIV composition comprising (a) at least one member selected from the group consisting of trifluridine and derivatives thereof, (b) a thymidine phosphorylase inhibitor, and a pharmaceutically acceptable carrier; and a composition for potentiating the anti-HIV activity of trifluridine and derivatives thereof, comprising a thymidine phosphorylase inhibitor and a pharmaceutically acceptable carrier.Type: GrantFiled: May 3, 2002Date of Patent: July 22, 2003Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Hiroo Hoshino, Kenji Kitazato, Masakazu Fukushima
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Patent number: 5849797Abstract: Now are provided (R)-3,6-diamino-N-(.omega.-aminoalkyl)-hexanamides which are novel compounds having the general formula (I): ##STR1## wherein n stands for 2-5, and which may be for example, (R)-3,6-diamino-N-(2-aminoethyl)hexanamide (n=2) and (R)-3,6-diamino-N-(3-aminopropyl)hexanamide (n=3). Their preparation process is also provided. These novel compounds and acid addition salts thereof have activities inhibitory against Gram-positive bacteria, Gram-negative bacteria and AIDS virus, as well as tumor cells and are chemically stable.These novel compounds and their salts are useful as chemotherapeutic agents for diseases caused by these bacteria or virus and also as antitumor agent.Type: GrantFiled: February 24, 1997Date of Patent: December 15, 1998Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Shinichi Kondo, Yoko Ikeda, Tomio Takeuchi, Rie Shinei, Shuichi Gomi, Seiji Shibahara, Hiroo Hoshino
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Patent number: 5665779Abstract: D-.beta.-Lysylmethanediamine represented by the formula (I) ##STR1## or a salt or a hydrate thereof has now been found to have an activity of inhibiting the infection with AIDS virus (a virus causative of acquired human immunodeficiency syndrome), mamely HIV. A pharmaceutical composition comprising the above compound or a salt or hydrate thereof as active ingredient is provided and expectable as one of remedial agents for treating AIDS which is now thought to be difficult to cure.Type: GrantFiled: June 24, 1994Date of Patent: September 9, 1997Assignee: Zaidan, Hojin, Biseibutsu, Kagaku, Kenkyu, KaiInventors: Shinichi Kondo, Yoko Ikeda, Masa Hamada, Tomio Takeuchi, Hiroo Hoshino
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Patent number: 5374625Abstract: A novel nucleic acid derivative represented by the following general formula (I) and physiologically acceptable salt thereof which are expected to have an antiviral activity: ##STR1## wherein B represents a nucleic acid base derivative; A.sup.1 and A.sup.2 represent, independently of each other, OR.sup.1 or OCOR.sup.1 ; R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; l represents a number of 0 or 1; and m and n each represents an integer of 0-2; provided that when l and m are 0, n is 0 or 2.Type: GrantFiled: July 17, 1991Date of Patent: December 20, 1994Assignee: Nippon Kayaku Kabushiki KaishaInventors: Yuh-ichiro Ichikawa, Hiroshi Akaba, Yuka Sugawara, Akira Shiozawa, Kenichi Matsubara, Takemitsu Nagahata, Hiroo Hoshino, Jun-ichi Seki
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Patent number: 5283331Abstract: It was found that 2-halogeno-oxetanocin A and 4'-phosphate thereof represented by the following general formula (1): ##STR1## wherein X represents a halogen atom and R represents a hydrogen atom or a phosphoric acid residue ##STR2## or salts thereof exhibit a strong antiviral activity and are useful as an active ingredient of therapeutic drug for viral diseases. Further, it was also found that the compounds of this invention are characterized in that they are not inactivated by adenosine deaminase widely present in living bodies and exhibit a high residual activity.Type: GrantFiled: December 9, 1991Date of Patent: February 1, 1994Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Akira Masuda, Masayuki Kitagawa, Nobuyoshi Shimada, Jun-ichi Seki, Hiroo Hoshino, Yukihiro Nishiyama
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Patent number: 5214048Abstract: This invention relates to novel oxetanocins represented by the following general formula (I): ##STR1## wherein R represents a group represented by ##STR2## and their pharmacologically acceptable salts which have antiviral activities.Type: GrantFiled: November 20, 1989Date of Patent: May 25, 1993Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Shigeru Hasegawa, Takayuki Tomizawa, Seiichi Saito, Kyoichi Shibuya, Akio Fujii, Hiroo Hoshino, Kenichi Matsubara, Takemitsu Nagahata, Katsutoshi Takahashi, Yukihiro Nishiyama
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Patent number: 5179084Abstract: The present invention relates to phosphoric acid esters of oxetanocins having an antiviral activity which are represented by general formula (I): ##STR1## wherein R.sub.1 represents a phosphoric acid ester residue, X represents hydrogen, hydroxy or hydroxymethyl group, and B represents a purine base residue, and pharmacologically acceptable salts thereof.Type: GrantFiled: April 4, 1990Date of Patent: January 12, 1993Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Shigeru Hasegawa, Masayuki Kitagawa, Nobuyoshi Shimada, Katsutoshi Takahashi, Jun-ichi Seki, Hiroo Hoshino, Yukihiro Nishiyama, Kenichi Matsubara, Takemitsu Nagahata
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Patent number: 5120717Abstract: Pharmaceutical compositions containing at least one of benanomicins A and B and their salts are now provided, which are useful to inhibit the infection of human T-cells with HIV, namely a virus causative of acquired human immunodeficiency syndrome (AIDS). Thus, benanomicins A and B as well as their salts are useful as antiviral agent against HIV.Type: GrantFiled: August 16, 1989Date of Patent: June 9, 1992Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Shinichi Kondo, Hiroo Hoshino
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Patent number: 5093323Abstract: As a new compound is now provided N-acetylbenanomicin B which is useful as an antifungal agent and also as antiviral agent for inhibiting infection of human T-cell with HIV, namely a virus causative of acquired human immunodeficiency syndrome. N-acetylbenanomicin B may be prepared by acetylation of 4"-amino group of benanomicin B which is fermentatively produced by a new microorganism, MH193-16F4 strain of actinomycetes.Type: GrantFiled: December 29, 1989Date of Patent: March 3, 1992Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Shinichi Kondo, Shuichi Gomi, Hiroo Hoshino
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Patent number: 5041447Abstract: This invention relates to oxetanocin-related compounds represented by the following formula (I): ##STR1## [in formula (I), R.sub.1, Y and B have the following meanings: (a) R.sub.1 represents --CH.sub.2 OH or --CH.sub.2 OCO-(alkyl),(b) Y represents ##STR2## provided that R.sub.2 is --H, --OH or --CH.sub.2 OH and R.sub.3 is --H, --OH, halogen atom, --CH.sub.2 OH, lower alkyl group, --CH.sub.2 -N.sub.3, --CH.sub.2 -F, --N.sub.3, --COOH, --NH.sub.2, --CH.sub.2 OSO.sub.3 H or --CH.sub.2 OCO-(lower alkyl), and(c) B represents a residue of purine base,(d) provided that R.sub.1 and R.sub.3 cannot simultaneously represents --CH.sub.2 OH]and their salts which have activities such as an antiviral activity and the like and are expectedly useful as a pharmaceutical and the like.Type: GrantFiled: March 17, 1989Date of Patent: August 20, 1991Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Shigeru Hasegawa, Katsutoshi Takahashi, Nobuyoshi Shimada, Jun-ichi Seki, Hiroo Hoshino, Yukihiro Nishiyama, Kenichi Matsubara, Takemitsu Nagahata
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Patent number: 5028598Abstract: Oxetanocin derivatives represented by formula: ##STR1## wherein X represents H or ##STR2## or a pharmacologically acceptable salt thereof exhibit an anti-viral activity. Anti-viral compositions comprising the oxetanocin derivatives or their pharmacologically acceptable salts as the effective ingredient are also provided.Type: GrantFiled: August 27, 1990Date of Patent: July 2, 1991Assignee: Nippon Kayaku Kabushiki KaishaInventors: Katsuhiko Kurabayashi, Junichi Seki, Haruo Machida, Hiroshi Yoshikawa, Hiroo Hoshino, Seiichi Saito, Masayuki Kitagawa
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Patent number: 4892876Abstract: A pharmaceutical composition for inhibiting Human Immunodeficiency Virus (HIV), which is characterized by comprising a compound represented by the formula (1) ##STR1## or a pharmaceutically acceptable salt thereof as an active ingredient.Type: GrantFiled: March 24, 1988Date of Patent: January 9, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Hiroo Hoshino, Nobuyoshi Shimada
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Patent number: 4845215Abstract: The present invention relates to a novel compound having hypoxanthine base represented by the following formula: ##STR1## as well as to use of said compound and process for producing said compound.The novel compound of the present invention has an immunosuppressive and antiviral actions and is expected to be useful as a medical drug.Type: GrantFiled: May 26, 1987Date of Patent: July 4, 1989Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Takayuki Tomizawa, Shigeru Hasegawa, Kaoru Matsuo, Akio Fujii, Hiroo Hoshino