Patents by Inventor Hiroomi Kiyono

Hiroomi Kiyono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing alpha form crystals of sapropterin hydrochloride
    Patent number: 8039617
    Abstract: A method for selectively producing stable alpha form crystals of sapropterin hydrochloride is provided. In this method, the alpha form crystal of sapropterin hydrochloride is produced by dissolving sapropterin hydrochloride with hydrochloric acid at a concentration of not less than 4 mol/L at not less than 70 degrees C.; adding heated ethanol to the solution; and cooling the solution at a cooling rate of not faster than 3 degrees C./min to a temperature of 40 to 55 degrees C. to precipitate the crystals.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: October 18, 2011
    Assignees: Shiratori Pharmaceutical Co., Ltd., Daiichi Sankyo Company, Limited
    Inventors: Katsumi Hotoda, Hiroomi Kiyono, Shinnosuke Tazawa
  • METHOD FOR PRODUCING ALPHA FORM CRYSTALS OF SAPROPTERIN HYDROCHLORIDE
    Publication number: 20090270619
    Abstract: A method for selectively producing stable alpha form crystals of sapropterin hydrochloride is provided. In this method, the alpha form crystal of sapropterin hydrochloride is produced by dissolving sapropterin hydrochloride with hydrochloric acid at a concentration of not less than 4 mol/L at not less than 70 degrees C.; adding heated ethanol to the solution; and cooling the solution at a cooling rate of not faster than 3 degrees C./min to a temperature of 40 to 55 degrees C. to precipitate the crystals.
    Type: Application
    Filed: April 13, 2006
    Publication date: October 29, 2009
    Applicant: Shiratori Pharmaceutical Co., Ltd.
    Inventors: Katsumi Hotoda, Hiroomi Kiyono, Shinnosuke Tazawa