Patents by Inventor Hiroshi Aiba

Hiroshi Aiba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9796963
    Abstract: The present invention provides a novel glucose dehydrogenase that has excellent substrate specificity and that is suitable for use in SMBG. The present invention provides a flavin-bound glucose dehydrogenase having the following characteristics (1) to (5): (1) Temperature stability: stable at a temperature of 45° C. or lower; (2) stable at a pH range of 4.5 to 7.5; (3) substrate specificity: the reactivity to D-xylose, maltose, or D-galactose is 2% or less, based on the reactivity to D-glucose taken as 100%; (4) optimal activity temperature: 34 to 47° C.; and (5) optimal activity pH: 6.3 to 6.7.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: October 24, 2017
    Assignee: Toyobo Co., Ltd.
    Inventors: Yasuhiro Yamazaki, Yosuke Sumida, Rie Hirao, Yuu Utashima, Hiroshi Aiba, Takahide Kishimoto, Shusaku Yanagidani
  • Patent number: 9657325
    Abstract: Provided is a flavin adenine dinucleotide-dependent glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 78% or more identity to the amino acid sequence of SEQ ID NO: 3, and having glucose dehydrogenase activity.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: May 23, 2017
    Assignee: Toyobo Co., Ltd.
    Inventors: Hiroshi Aiba, Yosuke Sumida, Yasuhiro Yamazaki, Yuu Utashima, Takahide Kishimoto
  • Patent number: 9506042
    Abstract: The present invention provides a novel glucose dehydrogenase that has excellent substrate specificity, specific activity, thermal stability, and the like, and that is suitable for use in SMBG sensors. The present invention provides a purified polypeptide comprising an amino acid sequence having at least 80% identity to the sequence of SEQ ID NO: 1 and having glucose dehydrogenase activity.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: November 29, 2016
    Assignee: Toyobo Co., Ltd.
    Inventors: Yosuke Sumida, Rie Hirao, Yuu Utashima, Hiroaki Kitazawa, Hiroshi Aiba, Takahide Kishimoto, Shusaku Yanagidani
  • Patent number: 9487758
    Abstract: An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. An isolated flavin-binding glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 80% or more identity to the amino acid sequence of SEQ ID NO: 1, and having glucose dehydrogenase activity is provided.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: November 8, 2016
    Assignee: Toyobo Co., Ltd.
    Inventors: Yosuke Sumida, Hiroshi Aiba, Hiroshi Kawaminami, Rie Hirao, Yuu Utashima, Takahide Kishimoto, Shusaku Yanagidani
  • Publication number: 20160265021
    Abstract: Provided is a flavin adenine dinucleotide-dependent glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 78% or more identity to the amino acid sequence of SEQ ID NO: 3, and having glucose dehydrogenase activity.
    Type: Application
    Filed: April 21, 2016
    Publication date: September 15, 2016
    Applicant: TOYOBO CO., LTD.
    Inventors: Hiroshi AIBA, Yosuke SUMIDA, Yasuhiro YAMAZAKI, Yuu UTASHIMA, Takahide KISHIMOTO
  • Patent number: 9404144
    Abstract: An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. The flavin-binding glucose dehydrogenase of the invention has the following characteristics (1) and (4): (1) Molecular weight: the molecular weight of a polypeptide moiety in the enzyme is about 68 kDa as measured by SDS-polyacrylamide electrophoresis; (2) Km value: the Km value for D-glucose is about 15 mM or less; (3) Temperature stability: stable at a temperature of 55° C. or less; and (4) pH stability: stable at a pH range of 3.0 to 8.5.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: August 2, 2016
    Assignee: TOYOBO CO., LTD.
    Inventors: Yosuke Sumida, Rie Hirao, Yuu Utashima, Hiroshi Kawaminami, Hiroshi Aiba, Takahide Kishimoto, Shusaku Yanagidani
  • Publication number: 20160154955
    Abstract: According to one embodiment, a terminal device includes a lock unit configured to lock input when not used, a first communication unit configured to receive a security code from an electronic device attachable to a user, and an unlock unit configured to release a state locked by the lock unit based on the security code received by the first communication unit.
    Type: Application
    Filed: February 3, 2016
    Publication date: June 2, 2016
    Inventors: Hironori Motoe, Hiroshi Aiba
  • Patent number: 9260699
    Abstract: An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. An isolated flavin-binding glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 80% or more identity to the amino acid sequence of SEQ ID NO: 1, and having glucose dehydrogenase activity is provided.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: February 16, 2016
    Assignee: Toyobo Co., Ltd.
    Inventors: Yosuke Sumida, Hiroshi Aiba, Hiroshi Kawaminami, Rie Hirao, Yuu Utashima, Takahide Kishimoto, Shusaku Yanagidani
  • Publication number: 20150332658
    Abstract: According to one embodiment, in a computer apparatus connecting a display dock including a display device and an operation dock whose back surface is a placement surface, an imaging device configured to capture an image in accordance with an imaging instruction input is provided on the back surface of the operation dock, and when the computer apparatus is placed, an image of a set place is captured by the imaging device in accordance with a display instruction input and is displayed in the display device of the display dock.
    Type: Application
    Filed: December 30, 2014
    Publication date: November 19, 2015
    Inventors: Kazuhiro Nakamura, Hiroshi Aiba
  • Publication number: 20150261947
    Abstract: According to one embodiment, an electronic device attachable to a user includes a sensor, a first controller and a second controller. The sensor detects the movement of the electronic device. The first controller wirelessly communicates with a terminal device. The second controller controls the terminal device based on a signal state of the sensor and a communication state of the first controller.
    Type: Application
    Filed: September 25, 2014
    Publication date: September 17, 2015
    Inventors: Hironori Motoe, Hiroshi Aiba
  • Patent number: 9133446
    Abstract: The present invention provides AP that has a high specific activity and preferably has superior reactivity with respect to various luminescent substrates generally used for high-sensitivity immunoassay analysis. Further preferably, the present invention provides AP having a thermal stability higher than that of CIAP. The alkaline phosphatase of the present invention is derived from the genus Shewanella and has the following characteristics: (A) molecular weight: about 104,000; (B) optimum reaction pH: about 9.5; (C) stable pH range: 5.5 to 10.4; (D) thermal stability: 65° C., and (E) specific activity: 5,000 U/mg or more.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: September 15, 2015
    Assignee: TOYOBO CO., LTD.
    Inventors: Hiroshi Aiba, Takahide Kishimoto, Yoshiaki Nishiya
  • Publication number: 20150240216
    Abstract: The present invention provides a novel glucose dehydrogenase that has excellent substrate specificity and that is suitable for use in SMBG. The present invention provides a flavin-bound glucose dehydrogenase having the following characteristics (1) to (5): (1) Temperature stability: stable at a temperature of 45° C. or lower; (2) stable at a pH range of 4.5 to 7.5; (3) substrate specificity: the reactivity to D-xylose, maltose, or D-galactose is 2% or less, based on the reactivity to D-glucose taken as 100%; (4) optimal activity temperature: 34 to 47° C.; and (5) optimal activity pH: 6.3 to 6.7.
    Type: Application
    Filed: September 6, 2013
    Publication date: August 27, 2015
    Inventors: Yasuhiro Yamazaki, Yosuke Sumida, Rie Hirao, Yuu Utashima, Hiroshi Aiba, Takahide Kishimoto, Shusaku Yanagidani
  • Publication number: 20150111280
    Abstract: The present invention provides a novel glucose dehydrogenase that has excellent substrate specificity, specific activity, thermal stability, and the like, and that is suitable for use in SMBG sensors. The present invention provides a purified polypeptide comprising an amino acid sequence having at least 80% identity to the sequence of SEQ ID NO: 1 and having glucose dehydrogenase activity.
    Type: Application
    Filed: December 29, 2014
    Publication date: April 23, 2015
    Inventors: Yosuke SUMIDA, Rie HIRAO, Yuu UTASHIMA, Hiroaki KITAZAWA, Hiroshi AIBA, Takahide KISHIMOTO, Shusaku YANAGIDANI
  • Publication number: 20150031059
    Abstract: An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. The flavin-binding glucose dehydrogenase of the invention has the following characteristics (1) and (4): (1) Molecular weight: the molecular weight of a polypeptide moiety in the enzyme is about 68 kDa as measured by SDS-polyacrylamide electrophoresis; (2) Km value: the Km value for D-glucose is about 15 mM or less; (3) Temperature stability: stable at a temperature of 55° C. or less; and (4) pH stability: stable at a pH range of 3.0 to 8.5.
    Type: Application
    Filed: February 7, 2013
    Publication date: January 29, 2015
    Applicant: TOYOBO CO., LTD.
    Inventors: Yosuke Sumida, Rie Hirao, Yuu Utashima, Hiroshi Kawaminami, Hiroshi Aiba, Takahide Kishimoto, Shusaku Yanagidani
  • Publication number: 20140287478
    Abstract: An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. An isolated flavin-binding glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 80% or more identity to the amino acid sequence of SEQ ID NO: 1, and having glucose dehydrogenase activity is provided.
    Type: Application
    Filed: April 30, 2014
    Publication date: September 25, 2014
    Inventors: Yosuke SUMIDA, Hiroshi AIBA, Hiroshi KAWAMINAMI, Rie HIRAO, Yuu UTASHIMA, Takahide KISHIMOTO, Shusaku YANAGIDANI
  • Publication number: 20140154777
    Abstract: An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. An isolated flavin-binding glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 80% or more identity to the amino acid sequence of SEQ ID NO: 1, and having glucose dehydrogenase activity is provided.
    Type: Application
    Filed: February 10, 2014
    Publication date: June 5, 2014
    Applicant: TOYOBO CO., LTD.
    Inventors: Yosuke SUMIDA, Hiroshi AIBA, Hiroshi KAWAMINAMI, Rie HIRAO, Yuu UTASHIMA, Takahide KISHIMOTO, Shusaku YANAGIDANI
  • Publication number: 20140030790
    Abstract: The present invention provides AP that has a high specific activity and preferably has superior reactivity with respect to various luminescent substrates generally used for high-sensitivity immunoassay analysis. Further preferably, the present invention provides AP having a thermal stability higher than that of CIAP. The alkaline phosphatase of the present invention is derived from the genus Shewanella and has the characteristics below: (A) molecular weight: about 104,000; (B) optimum reaction pH: about 9.5; (C) stable pH range: 5.5 to 10.4; (D) thermal stability: 65° C.; and (E) specific activity: 5,000 U/mg or more.
    Type: Application
    Filed: August 22, 2013
    Publication date: January 30, 2014
    Applicant: TOYOBO CO., LTD.
    Inventors: Hiroshi Aiba, Takahide Kishimoto, Yoshiaki Nishiya
  • Patent number: 8394615
    Abstract: The invention provides a glucose dehydrogenase that is an extremely stable enzyme having a thermostability of 80° C. or more, and that does not substantially act upon saccharides other than glucose (e.g., having a reactivity of less than 3% with respect to maltose, galactose, and xylose). The invention also provides a method for producing such an enzyme, and a composition for quantifying glucose using such an enzyme.
    Type: Grant
    Filed: December 26, 2008
    Date of Patent: March 12, 2013
    Assignees: Toyo Boseki Kabushiki Kaisha, Kyoto University
    Inventors: Hiroshi Aiba, Yoshiaki Nishiya, Tadayuki Imanaka, Haruyuki Atomi
  • Patent number: 8144483
    Abstract: According to one embodiment, an electronic apparatus includes a casing, a board contained in the casing, a support surface provided in the casing and supports the board, a first fixing portion provided integrally with the support surface and holds the board between itself and the support surface, and a second fixing portion provided integrally with the support surface. The second fixing portion is elastically displaced between a first position where the second fixing portion engages with the board and a second position where the projecting portion is removed from the board.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: March 27, 2012
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Kazuhiro Nakamura, Hiroshi Aiba
  • Publication number: 20110314267
    Abstract: According to one embodiment, an electronic device includes a display module, a power button, at least one function button, a hardware controller, and a pre-OS boot processor. The display module displays display data processed by an application on an operating system (OS) or display data based on received broadcast waves. The power button is operated to power on or off the electronic device. The function button is provided separately from a hardware keyboard having a plurality of keys to control a function defined on the OS. The hardware controller is activated in response to power-on operation made on the power button and provide the OS with basic input/output mechanism with respect to hardware including the function button. The pre-OS boot processor performs a process before boot-up of the OS if a predetermined operation is made on the function button within a predetermined time since the power-on operation is made.
    Type: Application
    Filed: April 25, 2011
    Publication date: December 22, 2011
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Hideki WATANABE, Hiroshi AIBA