Abstract: An information processing device for predicting a serum sodium concentration at a future time has a predictor acquisition unit and a prediction execution unit. The predictor acquisition unit acquires a target person's predictor to be predicted; the predictor includes a measured value of the serum sodium concentration at a reference time and an index value indicating the sodium intake in a future period, which is a period from the reference time to the future time. The prediction execution unit inputs the target person's acquired predictor into a serum sodium concentration prediction model created by machine learning using training data, where the predictor and a measured value of the serum sodium concentration at the future time are associated with each other, and predicts the target person's serum sodium concentration at the future time.

Abstract: The problem of the present invention is to provide a new drug for preventing, suppressing the progression of symptoms of, suppressing the recurrence of, or treating cancer. The inventors of the present invention, as a result of intensive investigation, focused on Allergin-1, a target molecule involved in the regulation of cancer immunity, found a bispecific antibody capable of specifically binding to two different epitopes on extracellular domains of Allergin-1, respectively, as a substance which can resolve the above problem, and confirmed that the antibody is useful for preventing, suppressing the progression of symptoms of, suppressing the recurrence of, or treating cancer.

Abstract: To provide an armrest that enables suppression of deterioration of the mountability of an accommodation member to a frame and that can make it less likely for the accommodation member to be detached from the frame. A claw of a second engaging portion and a second to-be-engaged portion are opposed to each other in a first direction (the direction of arrows U-D) over an overlap length in a state where an extending portion of the second engaging portion has been brought into contact with an outer peripheral surface of a body portion by elastically deforming the extending portion about a base side from a state where the claw is hooked on the second to-be-engaged portion.

Abstract: There is provided a method for efficient differentiation induction from human pluripotent stem cells into hypothalamic neurons. Also, provided is a method for constructing, from human pluripotent stem cells, a cellular structure in which hypothalamic tissue and pituitary tissue are integrated. A cellular structure including hypothalamic tissue is obtained by a method including the steps of: culturing an aggregate of human pluripotent stem cells in suspension in a medium containing a low concentration of a bone morphogenetic protein signal transduction pathway activating substance and a low concentration of a substance acting on the Shh signaling pathway; and further culturing the cell aggregate obtained in the step in suspension in a medium containing a low concentration of a substance acting on the Shh signaling pathway.

Abstract: A method for suppression of progress of, suppression of recurrence of and/or treatment of cancer includes administering an Allergin-1 antagonist in a therapy of a cancer patient with insufficient therapeutic efficacy by a tumor immunotherapeutic agent, or a cancer therapy in combination with an anti-cancer drug.

Abstract: A method for suppression of progress of, suppression of recurrence of and/or treatment of cancer, by administering an Allergin-1 antagonist in a therapy of a cancer patient with insufficient therapeutic efficacy by a tumor immunotherapeutic agent, or a cancer therapy in combination with an anti-cancer drug.

Abstract: A finisher-connecting structure for connecting a front finisher, which is disposed on one part of a vehicle seat, and a side finisher, which is disposed on another part of a vehicle seat, comprising a connection protrusion provided to the front finisher, and a connection recess that is provided to the side finisher and that fits with the connection protrusion; wherein the connection protrusion and the connection recess extend in a direction that intersects a direction in which the front finisher and the side finisher are continuous; wherein the fitted-together connection protrusion and connection recess regulate the front-rear-direction positions of the front finisher and the side finisher. In this connecting structure, which connects a pair of finishers using a connection protrusion and a connection recess, an unnecessary gap, such as a V-shaped gap, is prevented from being formed in the connected portion of the finishers.

Abstract: A finisher-connecting structure for connecting a front finisher, which is disposed on one part of a vehicle seat, and a side finisher, which is disposed on another part of a vehicle seat, comprising a connection protrusion provided to the front finisher, and a connection recess that is provided to the side finisher and that fits with the connection protrusion; wherein the connection protrusion and the connection recess extend in a direction that intersects a direction in which the front finisher and the side finisher are continuous; wherein the fitted-together connection protrusion and connection recess regulate the front-rear-direction positions of the front finisher and the side finisher. In this connecting structure, which connects a pair of finishers using a connection protrusion and a connection recess, an unnecessary gap, such as a V-shaped gap, is prevented from being formed in the connected portion of the finishers.

Abstract: There is provided a method for efficient differentiation induction from human pluripotent stem cells into hypothalamic neurons. Also, provided is a method for constructing, from human pluripotent stem cells, a cellular structure in which hypothalamic tissue and pituitary tissue are integrated. A cellular structure including hypothalamic tissue is obtained by a method including the steps of: culturing an aggregate of human pluripotent stem cells in suspension in a medium containing a low concentration of a bone morphogenetic protein signal transduction pathway activating substance and a low concentration of a substance acting on the Shh signaling pathway; and further culturing the cell aggregate obtained in the step in suspension in a medium containing a low concentration of a substance acting on the Shh signaling pathway.

Abstract: A method for suppression of progress of, suppression of recurrence of and/or treatment of cancer, by administering an Allergin-1 antagonist in a therapy of a cancer patient with insufficient therapeutic efficacy by a tumor immunotherapeutic agent, or a cancer therapy in combination with an anti-cancer drug.

Abstract: A developing apparatus including a substrate holder that holds a substrate horizontally; means for atomizing a surface treatment liquid used to improve wettability of the substrate with a developer; a first spray nozzle that sprays the atomized surface treatment liquid onto the substrate; and a developer supply nozzle that supplies a developer onto the substrate to which the substrate treatment liquid has been sprayed. The surface tension of the atomized surface treatment liquid with respect to the substrate is lower than the surface tension of the surface treatment liquid with respect to the substrate. The atomization suppresses the fact that the surface treatment liquid gathers on a certain portion of the surface of the substrate. The surface treatment liquid can be easily supplied onto the entire surface of the substrate, and improve wettability of the substrate with the developer.

Abstract: There is provided a developing apparatus and a developing method capable of rapidly forming a liquid film of a developing solution on an entire surface of a substrate while reducing a usage amount of the developing solution. The developing apparatus includes an airtightly sealed processing vessel that forms a processing atmosphere therein; a temperature control plate that is provided within the processing vessel and mounts the substrate thereon; an atmosphere gas supply unit that supplies an atmosphere gas including mist and vapor of a developing solution onto a surface of the substrate within the processing vessel; and a first temperature control unit that controls the temperature control plate to a temperature allowing the atmosphere gas to be condensed on the substrate. Here, an inner wall of the processing vessel is maintained at a temperature at which the atmosphere gas is hardly condensed on the inner wall.

Abstract: There is provided a developing apparatus capable of achieving high throughput. The developing apparatus includes an airtightly sealed processing vessel that forms a processing atmosphere therein; an atmosphere gas supply unit that supplies an atmosphere gas containing mist of a developing solution into the processing vessel in order to form a liquid film of the developing solution on a surface of a substrate loaded into the processing vessel; and a drying unit that dries the substrate in order to stop a developing process by the liquid film. A reaction between a resist and the developing solution can be stopped. Therefore, a developing process can be performed in parallel with a cleaning process performed by a cleaning module and high throughput is achieved.

Abstract: A coating and developing apparatus develops a substrate of which surface is coated with resist and exposed to lights. The coating and developing apparatus includes a developing module; a cleaning module; and a transfer mechanism configured to transfer a substrate developed by the developing module to the cleaning module. The developing module includes an airtightly sealed processing vessel configured to form a processing atmosphere; a temperature control plate provided in the processing vessel and mounts thereon the substrate and cools the substrate; and an atmosphere gas supply unit configured to supply an atmosphere gas including mist of a developing solution to a surface of the substrate within the processing vessel. The cleaning module includes a mounting table configured to mount thereon the substrate; and a cleaning solution supply unit configured to supply a cleaning solution to the substrate mounted on the mounting table.

Abstract: A method for cleaning a surface of a substrate having a circuit pattern formed thereon, includes: forming a liquid film on the surface by feeding a cleaning solution onto the center of the surface while rotating the substrate with the substrate kept horizontal; forming a dry region by discharging gas to the center while moving a position of feed of the cleaning solution on the surface by a distance from the center toward the periphery of the substrate with the substrate being rotated; moving the position of feed of the cleaning solution on the surface toward the periphery at a speed equal to a speed at which the dry region is expanded toward the periphery while rotating the substrate; and controlling temperature of the cleaning solution to form the liquid film such that the temperature becomes higher than process atmosphere temperature on the surface during feed of the cleaning solution.

Abstract: There is provided a developing apparatus capable of achieving high throughput. The developing apparatus includes an airtightly sealed processing vessel that forms a processing atmosphere therein; an atmosphere gas supply unit that supplies an atmosphere gas containing mist of a developing solution into the processing vessel in order to form a liquid film of the developing solution on a surface of a substrate loaded into the processing vessel; and a drying unit that dries the substrate in order to stop a developing process by the liquid film. A reaction between a resist and the developing solution can be stopped. Therefore, a developing process can be performed in parallel with a cleaning process performed by a cleaning module and high throughput is achieved.

Abstract: There is provided a coating and developing apparatus that develops a substrate of which surface is coated with resist and exposed to lights. The coating and developing apparatus includes a developing module; a cleaning module; and a transfer mechanism configured to transfer a substrate developed by the developing module to the cleaning module. The developing module includes an airtightly sealed processing vessel configured to form a processing atmosphere; a temperature control plate provided in the processing vessel and mounts thereon the substrate and cools the substrate; and an atmosphere gas supply unit configured to supply an atmosphere gas including mist of a developing solution to a surface of the substrate within the processing vessel. The cleaning module includes a mounting table configured to mount thereon the substrate; and a cleaning solution supply unit configured to supply a cleaning solution to the substrate mounted on the mounting table.

Abstract: There is provided a developing apparatus and a developing method capable of rapidly forming a liquid film of a developing solution on an entire surface of a substrate while reducing a usage amount of the developing solution. The developing apparatus includes an airtightly sealed processing vessel that forms a processing atmosphere therein; a temperature control plate that is provided within the processing vessel and mounts the substrate thereon; an atmosphere gas supply unit that supplies an atmosphere gas including mist and vapor of a developing solution onto a surface of the substrate within the processing vessel; and a first temperature control unit that controls the temperature control plate to a temperature allowing the atmosphere gas to be condensed on the substrate. Here, an inner wall of the processing vessel is maintained at a temperature at which the atmosphere gas is hardly condensed on the inner wall.

Abstract: An arrangement of operation unit in one upper corner portion of seat back of automotive seat is disclosed, in which an operating lever of the operation unit is accommodated in a housing fixed to a connecting bracket disposed in such one upper corner portion, and a shape retaining bracket is fixed to the connecting bracket to retain the peripheral edge region of opening of a trim cover assembly through which an operating lever of the operation unit projects outwardly. The peripheral edge region is inserted between the shape regaining bracket and a bezel, and further, the connecting bracket, housing and trim cover assembly are connected with one another at a connecting point, thereby effectively retaining the peripheral edge region of opening of the trim cover assembly in a predetermined shape conforming to outer contour of the one upper corner portion of seat back.

Abstract: An arrangement of operation unit in one upper corner portion of seat back of automotive seat is disclosed, in which an operating lever of the operation unit is accommodated in a housing fixed to a connecting bracket disposed in such one upper corner portion, and a shape retaining bracket is fixed to the connecting bracket to retain the peripheral edge region of opening of a trim cover assembly through which an operating lever of the operation unit projects outwardly. The peripheral edge region is inserted between the shape regaining bracket and a bezel, and further, the connecting bracket, housing and trim cover assembly are connected with one another at a connecting point, thereby effectively retaining the peripheral edge region of opening of the trim cover assembly in a predetermined shape conforming to outer contour of the one upper corner portion of seat back.