Abstract: A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus is provided.

Abstract: A compressed air filter apparatus includes a main flow path as a flow path in which compressed air should circulate, formed in a body to extend from a first opening into a penetration hole, an upper inner flow path extending from the penetration hole to an upper inner space, an upper inner and outer flow path extending from the upper inner space to an upper outer space to pass through an upper filer element, a communication flow path extending from the upper outer space to a lower outer space to pass through a communication hole, a secondary flow path extending from the lower outer space to a second opening, a lower inner flow path extending from the penetration hole to a lower inner space, and a lower inner and outer flow path extending from the lower inner space to the lower outer space to pass through a lower filter element.

Abstract: A compressed air filter apparatus includes a main flow path as a flow path in which compressed air should circulate, formed in a body to extend from a first opening into a penetration hole, an upper inner flow path extending from the penetration hole to an upper inner space, an upper inner and outer flow path extending from the upper inner space to an upper outer space to pass through an upper filer element, a communication flow path extending from the upper outer space to a lower outer space to pass through a communication hole, a secondary flow path extending from the lower outer space to a second opening, a lower inner flow path extending from the penetration hole to a lower inner space, and a lower inner and outer flow path extending from the lower inner space to the lower outer space to pass through a lower filter element.

Abstract: A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus is provided.

Abstract: A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus is provided.

Abstract: An object of the present invention is to provide a highly-safe recombinant herpes virus showing high antitumor activity regardless of the kind, grade of malignancy, or growth rate of tumor cells. The present invention provides a recombinant herpes simplex virus and the like constructed to express an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus.

Abstract: Provided is a float type drain trap improved in terms of opening and closing of a valve seat. In the prior art, the valve seat is opened and closed mainly by a self-weight of a float and buoyancy of a float main body, so the valve seat is often left in a half-open state, with opening and closing of the valve seat being rather equivocal. Afloat is accommodated in a case, and drain water allowed to flow into the case is enabled to be discharged by buoyancy acting on the float. By providing a magnet between the case and the float, an attraction force is generated, and an outlet port formed in the case is closed or opened based on the relationship between the buoyancy, the attraction force, and the positions where these forces are generated, thereby making it possible to retain and discharge the drain water.

Abstract: A method is provided for rapidly and reliably constructing recombinant herpes simplex virus (HSV) capable of expressing a target protein in cancer cells. The method for constructing recombinant HSV as claimed in the present invention comprises a first step of inserting into a herpes simplex virus (HSV) genome, a BAC plasmid, which has a loxP site and an FRT site and into which has been inserted at least one type of marker gene expression cassette between the loxP site and the FRP site, a second step of constructing a shuttle vector into which has been respectively inserted at least one type of expression cassette of a gene encoding a target protein, at least one type of marker gene, a loxP site and an FRP site, and inserting the shuttle vector into the loxP site of the HSV genome using Cre recombinase, and a third step of co-infecting a host with the HSV genome and a vector capable of expressing Flp recombinase, and excising the region between the FRT sites in the genome to produce a target recombinant HSV.

Abstract: This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I-1), (I-2) or (I-3) The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against various bacterial strains and sufficient stability for practical use.

Abstract: The present invention provides novel synthetic intermediates for the production of indoline derivatives, which exhibit excellent ACAT inhibitory activity, and processes for the preparation thereof.

Abstract: The present invention provides novel synthetic intermediates for the production of indoline derivatives, which exhibit excellent ACAT inhibitory activity, and processes for the preparation thereof.

Abstract: This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof. The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against various bacterial strains and sufficient stability for practical use.

Abstract: A compressor generates compressed air. Iron powder is provided in a deoxidizing chamber. The compressed air is supplied to the deoxidizing chamber such that the compressed air reacts with the iron powder to form iron oxide, so that oxygen contained in the compressed air is reduced to obtain remained nitrogen gas.

Abstract: This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof.

Abstract: The present invention provides novel synthetic intermediates for the production of indoline derivatives, which exhibit excellent ACAT inhibitory activity, and processes for the preparation thereof.

Abstract: This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof.

Abstract: This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof.

Abstract: This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof.

Abstract: A process for producing aromatic carboxylic acids by subjecting an aromatic compound having one or more substituent alkyl groups and/or partially oxidized substituent alkyl groups to a liquid phase oxidation with a molecular oxygen-containing gas in a reaction solvent containing a lower aliphatic carboxylic acid in the presence of a catalyst composed of a heavy metal compound and a bromine compound, under a condition of a weight proportion of said reaction solvent to said aromatic compound within the range from 6.5 to 70 parts by weight per one part by weight of said aromatic compound, a reaction time within the range from 45 to 4.5 minutes and a product of the numerical value of said weight proportion of the reaction solvent to the aromatic compound multiplied by the numerical value of said reaction time expressed in munute within the range from 270 to 330.

Abstract: A method for producing aromatic carboxylic acids which comprises oxidizing a starting compound selected from the group consisting of alkyl substituted aromatic hydrocarbons and partially oxidized alkyl substituted aromatic hydrocarbons with a molecular oxygen containing gas in the presence of at least one additive selected from the group consisting of aliphatic hydrocarbons, alicyclic hydrocarbons, aliphatic alcohols, alicyclic alcohols, aldehydes, carboxylic acids and ketones and in the presence of a catalyst comprising a heavy metal compound and a bromine compound in a reaction solvent. The aliphatic alcohols, alicyclic alcohols, aldehydes, carboxylic acids and ketones have ten to thirty carbon atoms in the molecule.