Patents by Inventor Hiroshi Gushima

Hiroshi Gushima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tissue plasminogen activator and method of use
    Patent number: 5556621
    Abstract: The present invention relates to improved plasminogen activators (improved t-PA) which have a prolonged biological half life, an increased stability to heat and acids and can be expected to be effective as inhibiting inflammation around the site in which thrombus is formed.
    Type: Grant
    Filed: May 4, 1994
    Date of Patent: September 17, 1996
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Yasushi Kawauchi, Toshiyuki Takemoto, Makoto Takayama, Masami Yokota, Masao Kato, Kimio Katsuta, Hiroshi Gushima
  • 7-methoxy cephalosporin derivative
    Patent number: 4656262
    Abstract: The 7-methoxy-3-heterocyclic thiomethyl cephalosporin derivative possessing excellent antimicrobial activity represented by the general formula ##STR1## wherein R.sup.1 represents ##STR2## group or HOOC-- group, R.sup.2 represents a nitrogen-containing heterocyclic group, and M represents a hydrogen atom or a cation residue forming a salt.
    Type: Grant
    Filed: December 13, 1985
    Date of Patent: April 7, 1987
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Takashi Osono, Yoshihiko Oka, Shunichi Watanabe, Takeshi Saito, Hiroshi Gushima, Keisuke Murakami, Isao Takahashi, Hiroshi Yamaguchi, Toshio Sasaki, Kiyoshi Susaki, Shuichi Takamura, Toshiaki Miyoshi
  • Process for the production of 7.alpha.-methoxycephalosporin derivatives
    Patent number: 4410626
    Abstract: 7.alpha.-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7.alpha.-methoxycephalosporin derivatives.
    Type: Grant
    Filed: October 29, 1980
    Date of Patent: October 18, 1983
    Assignee: Yamanouchi Pharmaceutical Co. Ltd.
    Inventors: Hiroshi Gushima, Shunichi Watanabe, Takeshi Saito, Toshio Sasaki, Hideo Eiki, Yoshihiko Oka, Takashi Osono
  • 7.alpha.-Methoxycephalosporin derivatives
    Patent number: 4259326
    Abstract: 7.alpha.-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7.alpha.-methoxycephalosporin derivatives.
    Type: Grant
    Filed: November 27, 1979
    Date of Patent: March 31, 1981
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Gushima, Shunichi Watanabe, Takeshi Saito, Toshio Sasaki, Hideo Eiki, Yoshihiko Oka, Takashi Osono
  • 7-Methoxy cephalosporins and process of producing them
    Patent number: 4242449
    Abstract: The 7-methoxy-3-heterocyclic thiomethyl cephalosporin derivative possessing excellent antimicrobial activity represented by the general formula ##STR1## wherein R.sup.1 represents ##STR2## group or HOOC-- group, R.sup.2 represents a nitrogen-containing heterocyclic group, and M represents a hydrogen atom or a cation residue forming a salt.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: December 30, 1980
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Takashi Osono, Yoshihiko Oka, Shunichi Watanabe, Takeshi Saito, Hiroshi Gushima, Keisuke Murakami, Isao Takahashi, Hiroshi Yamaguchi, Toshio Sasaki, Kiyoshi Susaki, Shuichi Takamura, Toshiaki Miyoshi
  • Antibiotic Y-G19Z D3 and the production thereof
    Patent number: 4039660
    Abstract: A new antibiotic substance, designated Y-G19ZD3, is produced by the fermentation of a newly discovered microorganism Streptomyces organonensis Y-G19Z or a mutant thereof. The antibiotic substance Y-G19ZD3 is effective against gram negative bacteria and is useful also as an intermediate for the production of other antibiotics.
    Type: Grant
    Filed: September 16, 1975
    Date of Patent: August 2, 1977
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Takashi Osono, Shunichi Watanabe, Takeshi Saito, Hiroshi Gushima, Keisuke Murakami, Isao Takahashi, Hiroshi Yamaguchi, Toshio Sasaki, Yoshihiko Oka