Patents by Inventor Hiroshi HINO

Hiroshi HINO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMB POLYMER HAVING SALT GROUPS
    Publication number: 20240158582
    Abstract: The invention relates to a comb polymer having a polymer backbone and lateral side chains linked to the polymer backbone, wherein the lateral side chains comprise a) alkyl ether terminated polyalkylene oxide side chains, and b) tertiary amine-functional side chains, wherein the tertiary amine groups are at least partly neutralized by an acid having a molecular weight in the range of 100 g/mol to 2000 g/mol, wherein the molecular weight relates to the number average molecular weight Mn in the case of polymeric acids, and wherein the lateral side chains a) and b) are distributed in random order.
    Type: Application
    Filed: April 5, 2022
    Publication date: May 16, 2024
    Inventors: Hiroshi Yonehara, Andreas Okkel, Benjamin Lindner, Shinji Hino, Sabine Stelz, Ryo Takabayashi
  • Gene-modified mouse expressing human GPC3 polypeptide
    Patent number: 11793180
    Abstract: Genetically modified non-human animals which are deficient in expression of an endogenous GPC3 polypeptide and express a human GPC3 polypeptide at a physiologically adequate level; methods for producing the non-human animals; and methods for evaluating test substances using the non-human animals. Furthermore, methods for evaluating test substances regarding their safety, therapeutic effects on diseases, pharmacokinetics, in vivo distribution, and such, using the non-human animals as models.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: October 24, 2023
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Koichi Jishage, Hiroshi Hino, Takahiro Ishiguro, Yasuko Kinoshita
  • GENE-MODIFIED NON-HUMAN ANIMAL EXPRESSING HUMAN GPC3 POLYPEPTIDE
    Publication number: 20200229408
    Abstract: Genetically modified non-human animals which are deficient in expression of an endogenous GPC3 polypeptide and express a human GPC3 polypeptide at a physiologically adequate level; methods for producing the non-human animals; and methods for evaluating test substances using the non-human animals. Furthermore, methods for evaluating test substances regarding their safety, therapeutic effects on diseases, pharmacokinetics, in vivo distribution, and such, using the non-human animals as models.
    Type: Application
    Filed: August 21, 2017
    Publication date: July 23, 2020
    Inventors: Koichi JISHAGE, Hiroshi HINO, Takahiro ISHIGURO, Yasuko KINOSHITA
  • GENE-MODIFIED NON-HUMAN ANIMAL EXPRESSING HUMAN GPC3 POLYPEPTIDE
    Publication number: 20190174731
    Abstract: Genetically modified non-human animals which are deficient in expression of an endogenous GPC3 polypeptide and express a human GPC3 polypeptide at a physiologically adequate level; methods for producing the non-human animals; and methods for evaluating test substances using the non-human animals. Furthermore, methods for evaluating test substances regarding their safety, therapeutic effects on diseases, pharmacokinetics, in vivo distribution, and such, using the non-human animals as models.
    Type: Application
    Filed: August 21, 2017
    Publication date: June 13, 2019
    Inventors: Koichi JISHAGE, Hiroshi HINO, Takahiro ISHIGURO, Yasuko KINOSHITA