Abstract: The present invention relates to a method for identifying cells having a predisposition to develop an intestinal phenotype, wherein the cells are characterized by the loss of expression of the RUNX3 gene and the expression of one or more intestinal marker genes. In particular, the invention is directed to the identification of cells, which exhibit an intestinal phenotype representing a precursor of gastric cancer. Furthermore, the invention discloses a method for identifying a compound inhibiting the development of an intestinal phenotype in cells having a predisposition to develop an intestinal phenotype. Finally, the invention also relates to kits of parts for performing these methods.

Abstract: The present invention relates to a method for identifying cells having a predisposition to develop an intestinal phenotype, wherein the cells are characterized by the loss of expression of the RUNX3 gene and the expression of one or more intestinal marker genes. In particular, the invention is directed to the identification of cells, which exhibit an intestinal phenotype representing a precursor of gastric cancer. Furthermore, the invention discloses a method for identifying a compound inhibiting the development of an intestinal phenotype in cells having a predisposition to develop an intestinal phenotype. Finally, the invention also relates to kits of parts for performing these methods.

Abstract: The present invention relates to a method for identifying cells having a predisposition to develop an intestinal phenotype, wherein the cells are characterized by the loss of expression of the RUNX3 gene and the expression of one or more intestinal marker genes. In particular, the invention is directed to the identification of cells, which exhibit an intestinal phenotype representing a precursor of gastric cancer. Furthermore, the invention discloses a method for identifying a compound inhibiting the development of an intestinal phenotype in cells having a predisposition to develop an intestinal phenotype. Finally, the invention also relates to kits of parts for performing these methods.

Abstract: A method and apparatus for manufacturing helically coiled coupling elements for slide fasteners. There are provided a filament supply unit, a filament coiling unit, a filament drive unit interposed between the supply unit and the coiling unit, and a tension-applying unit disposed between the drive unit and the coiling unit. As a filament is formed into a fastener element in the form of a continuous helical coil at the filament coiling machine, the filament is unwound from a relatively large bobbin in the supply device and at the same time is rotated about its own axis by a rotor of the supply unit at the same rate and in the same direction as the filament is coiled at the coiling unit to thereby eliminate twists on the filament which would otherwise be produced at the latter unit. The drive unit is also adapted to rotate the filament about its own axis while positivey feeding the filament toward the coiling unit.