Patents by Inventor Hiroshi Ikawa
Hiroshi Ikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6812252Abstract: The present invention provides new acylsulfonamide derivatives such as 4-(3-trifluoromethyl)phenylethynyl-N-(2-(5-ketohexanoylamino)sulfonylphenyl)benzamide, 4-(3-trifluoromethyl)phenylethynyl-N-(2-(2-propyloxyacetylamino)sulfonylphenyl)benzamide or analogues thereof. These acylsulfonamide derivatives have a hypoglycemic effect equal to or superior to the effects of the conventional hypoglycemic agents and they are free from the side effects unlike the glitazone compounds.Type: GrantFiled: January 3, 2003Date of Patent: November 2, 2004Assignee: Ajinomoto Co., Inc.Inventors: Hiroshi Ikawa, Masato Nishimura, Keiji Okada, Takashi Nakamura, Kazuhiro Kojima, Hideki Kosono
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Publication number: 20030191323Abstract: The present invention provides a hypoglycemic agent containing an acylsulfonamide derivative such as a compound of the following formula or an analog thereof, which agent is usable for preventing and curing diabetes: 1Type: ApplicationFiled: January 2, 2003Publication date: October 9, 2003Applicant: Ajinomoto Co., Inc.Inventors: Hiroshi Ikawa, Masato Nishimura, Keiji Okada, Takashi Nakamura, Niro Inaba, Kazuhiro Kojima, Hideki Kosono
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Publication number: 20030181764Abstract: The present invention provides new acylsulfonamide derivatives such as 4-(3-trifluoromethyl)phenylethynyl-N-(2-(5-ketohexanoylamino)sulfonylphenyl)benzamide, 4-(3-trifluoromethyl)phenylethynyl-N-(2-(2-propyloxyacetylamino)sulfonylphenyl)benzamide or analogues thereof. These acylsulfonamide derivatives have a hypoglycemic effect equal to or superior to the effects of the conventional hypoglycemic agents and they are free from the side effects unlike the glitazone compounds.Type: ApplicationFiled: January 3, 2003Publication date: September 25, 2003Applicant: AJINOMOTO CO. INCInventors: Hiroshi Ikawa, Masato Nishimura, Keiji Okada, Takashi Nakamura, Kazuhiro Kojima, Hideki Kosono
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Publication number: 20030162818Abstract: This invention provides a novel acylsulfonamide derivative which can be used as an ACC activity inhibitor effective for the treatment of visceral fat syndrome that becomes the risk-factor of diseases of adult people such as myocardial infarction, cerebral infarction and diabetes.Type: ApplicationFiled: March 4, 2003Publication date: August 28, 2003Applicant: AJINOMOTO CO. INC.Inventors: Hiroshi Ikawa, Masato Nishimura, Keiji Okada, Takashi Nakamura
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Patent number: 6555584Abstract: This invention provides a novel acylsulfonamide derivative which can be used as an ACC activity inhibitor effective for the treatment of visceral fat syndrome that becomes the risk-factor of diseases of adult people such as myocardial infarction, cerebral infarction and diabetes.Type: GrantFiled: June 29, 2000Date of Patent: April 29, 2003Assignee: Ajinomoto Co., Inc.Inventors: Hiroshi Ikawa, Masato Nishimura, Keiji Okada, Takashi Nakamura
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Patent number: 6339089Abstract: A pyrimidine nucleus-containing compound represented by the formula (I): wherein ring A represents the ring of the formula (a): in which R1 is a nitro group, an amino group, a substituted amino group or a halogen atom, or the ring of the formula (b): in which R1′ is the group such as an alkyl group or an alkenyl group; R2 to R5 independently represent the group such as an alkyl group or an alkenyl group; with the proviso that at least one of R2 to R5 is an alkenyl group, or acid addition salts thereof.Type: GrantFiled: August 12, 1998Date of Patent: January 15, 2002Assignee: Fujirebio Inc.Inventors: Yoshiharu Nakashima, Takashi Fujita, Michiyo Hizuka, Hiroshi Ikawa, Toru Hiruma
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Publication number: 20010006969Abstract: A pyrimidine nucleus-containing compound represented by the formula (I): 1Type: ApplicationFiled: August 12, 1998Publication date: July 5, 2001Inventors: YOSHIHARU NAKASHIMA, TAKASHI FUJITA, MICHIYO HIZUKA, HIROSHI IKAWA, TORU HIRUMA
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Patent number: 6060602Abstract: A method of producing a 2-naphthamide derivative of formula (I) that can be employed as an antiallergic agent or an agent for curing allergosis, and compounds for producing the 2-naphthamide derivative are provided: ##STR1## wherein R.sup.1 and R.sup.2 are each independently an unsubstituted or substituted aromatic hydrocarbon group, or an unsubstituted or substituted aromatic heterocyclic group; R.sup.3 is an acyl group, an alkoxylcarbonyl group, a substituted carbamoyl group, or an unsubstituted or substituted alkyl group.Type: GrantFiled: December 21, 1998Date of Patent: May 9, 2000Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Masato Nishimura
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Patent number: 5965538Abstract: Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group; R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group,and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.Type: GrantFiled: August 24, 1998Date of Patent: October 12, 1999Assignee: Fujirebio Inc.Inventors: Yoshiharu Nakashima, Michiyo Hizuka, Yasushi Higashide, Tetsuaki Yamaura, Hiroshi Ikawa
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Patent number: 5917046Abstract: A method of producing a 2-naphthamide derivative of formula (I) that can be employed as an antiallergic agent or an agent for curing allergosis, and compounds for producing the 2-naphthamide derivative are provided: ##STR1## wherein R.sup.1 and R.sup.2 are each independently an unsubstituted or substituted aromatic hydrocarbon group, or an unsubstituted or substituted aromatic heterocyclic group; R.sup.3 is an acyl group, an alkoxylcarbonyl group, a substituted carbamoyl group, or an unsubstituted or substituted alkyl group.Type: GrantFiled: June 3, 1997Date of Patent: June 29, 1999Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Masato Nishimura
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Patent number: 5877333Abstract: A compound having the structure: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are each independently a hydrogen atom, an alkyl group or an aryl group, or wherein R.sup.2 and R.sup.3 together and R.sup.4 and R.sup.5 together are joined as a cycloalkyl group; wherein R.sup.6 is a hydroxyl group, an alkoxyl group, an aralkyloxy group, or --OSi (R.sup.8 R.sup.9 R.sup.10) in which R.sup.8, R.sup.9 and R.sup.10 are each independently an alkyl group or a phosphate salt group and R.sup.7 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxyl group.Type: GrantFiled: November 5, 1997Date of Patent: March 2, 1999Assignee: Fujirebio Inc.Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Hisako Kobayashi, Hiroshi Ikawa
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Patent number: 5859244Abstract: 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.Type: GrantFiled: May 13, 1997Date of Patent: January 12, 1999Assignee: Fujirebio, Inc.Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuko Konagai, Tetsuaki Yamaura, Noriko Kase
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Patent number: 5840977Abstract: A method of producing a pantothenic acid derivative of formula (I): ##STR1## wherein each of R.sup.1 and R .sup.2 is different, and is a branched aliphatic hydrocarbon group having 3 to 5 carbon atoms, or a phenyl group; or a straight chain aliphatic hydrocarbon group having 5 to 10 carbon atoms, is provided, including methods of producing the starting materials for producing the same and novel amine derivative that can be used for the production of the pantothenic acid derivative.Type: GrantFiled: August 6, 1997Date of Patent: November 24, 1998Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Hajime Matsumoto
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Patent number: 5837687Abstract: Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group;R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group,and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.Type: GrantFiled: March 17, 1995Date of Patent: November 17, 1998Assignee: Fujirebio Inc.Inventors: Yoshiharu Nakashima, Michiyo Hizuka, Yasushi Higashide, Tetsuaki Yamaura, Hiroshi Ikawa
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Patent number: 5763614Abstract: 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antagonism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.Type: GrantFiled: June 10, 1994Date of Patent: June 9, 1998Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuko Konagai, Tetsuaki Yamaura, Noriko Kase
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Patent number: 5731445Abstract: A 1,2-dioxetane derivative of formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are each independently a hydrogen atom, an alkyl group, or an aryl group, R.sup.2 and R.sup.3 together and R.sup.4 and R.sup.5 together can be joined as a cyclo-alkyl group, R.sup.6 is a hydroxyl group, an alkoxyl group, an aralkyloxy group, --OSi(R.sup.8 R.sup.9 R.sup.10) in which R.sup.8, R.sup.9 and R.sup.10 are each independently an alkyl group, or a phosphate salt, and R.sup.7 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxyl group.Type: GrantFiled: December 2, 1996Date of Patent: March 24, 1998Assignee: Fujirebio Inc.Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Hisako Kobayashi, Hiroshi Ikawa
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Patent number: 5719298Abstract: A method of producing a pantothenic acid derivative of formula (I): ##STR1## wherein each of R.sup.1 and R.sup.2 is different, and is a branched aliphatic hydrocarbon group having 3 to 5 carbon atoms, or a phenyl group; or a straight chain aliphatic hydrocarbon group having 5 to 10 carbon atoms, is provided, including methods of producing the starting materials for producing the same and novel amine derivative that can be used for the production of the pantothenic acid derivative.Type: GrantFiled: May 22, 1995Date of Patent: February 17, 1998Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Hajime Matsumoto
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Patent number: 5714613Abstract: A method of producing a 2-naphthamide derivative of formula (I) that can be employed as an antiallergic agent or an agent for curing allergosis, and compounds for producing the 2-naphthamide derivative are provided: ##STR1## wherein R.sup.1 and R.sup.2 are each independently an unsubstituted or substituted aromatic hydrocarbon group, or an unsubstituted or substituted aromatic heterocyclic group; R.sup.3 is an acyl group, an alkoxylcarbonyl group, a substituted carbamoyl group, or an unsubstituted or substituted alkyl group.Type: GrantFiled: June 4, 1996Date of Patent: February 3, 1998Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Masato Nishimura
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Patent number: 5696268Abstract: 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.Type: GrantFiled: June 2, 1995Date of Patent: December 9, 1997Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuko Konagai, Tetsuaki Yamaura, Noriko Kase
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Patent number: 5644059Abstract: 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.Type: GrantFiled: June 2, 1995Date of Patent: July 1, 1997Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuko Konagai, Tetsuaki Yamaura, Noriko Kase