Patents by Inventor Hiroshi Izutsu
Hiroshi Izutsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11869190Abstract: A method, a program, and a method determining hypermutated type cancer with higher accuracy than before is provided.Type: GrantFiled: April 4, 2022Date of Patent: January 9, 2024Assignees: Niigata University, Denka Company LimitedInventors: Toshifumi Wakai, Shujiro Okuda, Yoshifumi Shimada, Hiroshi Izutsu, Keisuke Kodama
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Publication number: 20230367621Abstract: A software providing apparatus that provides software for performing data processing concerning an oncogene, the software operating on a virtual machine and including a software module that executes data processing concerning an oncogene and setting information for determining an operation at a time when the software module executes the data processing, the software providing apparatus comprising a receiving unit that receives an instruction concerning providing the software to an at least one predetermined user group; and a generating unit that, when the instruction has been received, instructs an information processing apparatus which stores a template of a virtual machine including the software to duplicate the template of the virtual machine, hereby causing the information processing apparatus to generate a new virtual machine including software to be provided to the at least one predetermined user group.Type: ApplicationFiled: October 7, 2021Publication date: November 16, 2023Inventors: Shujiro OKUDA, Yu WATANABE, Hiroshi IZUTSU, Keisuke KODAMA
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Publication number: 20230148243Abstract: There is provided a data generation apparatus including a display control unit that displays, on a screen, an image and borders of a plurality of partial images generated by dividing the image into a plurality of pieces while the image and the borders are superimposed together, an input unit that receives input of a label to be given to each of the plurality of partial images, and a generation unit that generates learning data for causing a learning model to learn by associating each of the plurality of partial images with the label given to the corresponding partial image of the plurality of partial images.Type: ApplicationFiled: April 5, 2021Publication date: May 11, 2023Inventors: Shujiro OKUDA, Yu WATANABE, Hiroshi IZUTSU, Keisuke KODAMA
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Publication number: 20220301167Abstract: A method, a program, and a method determining hypermutated type cancer with higher accuracy than before is provided.Type: ApplicationFiled: April 4, 2022Publication date: September 22, 2022Applicants: Niigata University, Denka Company LimitedInventors: Toshifumi Wakai, Shujiro Okuda, Yoshifumi Shimada, Hiroshi Izutsu, Keisuke Kodama
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Patent number: 11295447Abstract: A method, a program, and a method determining hypermutated type cancer with higher accuracy than before is provided.Type: GrantFiled: February 7, 2019Date of Patent: April 5, 2022Assignees: Niigata University, Denka Company LimitedInventors: Toshifumi Wakai, Shujiro Okuda, Yoshifumi Shimada, Hiroshi Izutsu, Keisuke Kodama
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Publication number: 20210035300Abstract: A method, a program, and a method determining hypermutated type cancer with higher accuracy than before is provided.Type: ApplicationFiled: February 7, 2019Publication date: February 4, 2021Applicants: Niigata University, Denka Company LimitedInventors: Toshifumi Wakai, Shujiro Okuda, Yoshifumi Shimada, Hiroshi Izutsu, Keisuke Kodama
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Publication number: 20140080132Abstract: A method for predicting ADCC activity in a subject, the method comprising the steps of: (a) preparing a biological sample from the subject, said sample including a leukocyte, (b) bringing a portion of the biological sample and an antibody into contact with each other, (c) detecting expression of at least one marker of ADCC activity selected from the group consisting of tumor necrosis factor super family 15, chemokine CXCL3, and interleukin 6 in the leukocyte in (i) the portion of the sample brought into contact with the antibody and in (ii) another portion of the sample not brought into contact with the antibody, (d) comparing an expression level in portion (i) with the expression level in portion (ii); and (e) predicting presence of the cytotoxic activity when the expression level in portion (i) is higher than the expression level in portion (ii)Type: ApplicationFiled: September 16, 2013Publication date: March 20, 2014Inventors: Kazuhiko Obara, Hiroshi Izutsu, Masato Mitsuhashi, Fumiaki Koizumi, Kenji Tamura, Mayu Yunokawa, Yasuo Kodera, Fumiko Taguchi
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Patent number: 8268566Abstract: A method for predicting patient responsiveness to rheumatoid arthritis treatments involving altering expression of tumor necrosis factor superfamily (“TNFSF”)-2, TNFSF-8, or TNFSF-15 is disclosed. A method for monitoring the effectiveness of such therapy is also disclosed. Furthermore, a method of screening compounds for use in the treatment of rheumatoid arthritis is disclosed. A method of monitoring the disease state over time in rheumatoid arthritis patients is also disclosed.Type: GrantFiled: November 11, 2008Date of Patent: September 18, 2012Assignees: Hitachi Chemical Research Center, Inc., Hitachi Chemical Co., Ltd.Inventors: Masato Mitsuhashi, Katsuya Endo, Kazuhiko Obara, Hiroshi Izutsu, Shuji Ohta
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Publication number: 20100279296Abstract: A method for predicting patient responsiveness to rheumatoid arthritis treatments involving altering expression of tumor necrosis factor superfamily (“TNFSF”)-2, TNFSF-8, or TNFSF-15 is disclosed. A method for monitoring the effectiveness of such therapy is also disclosed. Furthermore, a method of screening compounds for use in the treatment of rheumatoid arthritis is disclosed. A method of monitoring the disease state over time in rheumatoid arthritis patients is also disclosed.Type: ApplicationFiled: November 11, 2008Publication date: November 4, 2010Applicants: HITACHI CHEMICAL CO., LTD., HITACHI CHEMICAL RESEARCH CENTER, INC.Inventors: Masato Mitsuhashi, Katsuya Endo, Kazuhiko Obara, Hiroshi Izutsu, Shuji Ohta
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Patent number: 6491924Abstract: Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding the antigenic polypeptides, or DNAs complementary thereto; a method for production of an anti-Chlamydia pneumoniae antibody, wherein the antigenic polypeptide is used as an antigen; a method for detection and/or measurement of an anti-Chlamydia pneumoniae antibody, which comprise the antigenic polypeptide as an antigen; agents for diagnosis of Chlamydia pneumoniae infections, which comprise the antigenic polypeptide as an active ingredient; fused proteins of an antigenic polypeptide of Chlamydia pneumoniae with dihydrofolate reudctase; a method for production of an anti-Chlamydia pneumoniae antibody, wherein the fused protein is used as an antigen; reagents for detection and/or measurement of an anti-Chlamydia pneumoniae antibody, which comprise the fused protein as an antigen; agents for diagnosis of Chlamydia pneumoniae infectType: GrantFiled: October 12, 2000Date of Patent: December 10, 2002Assignee: Hitachi Chemical Company, Ltd.Inventors: Hiroshi Izutsu, Kazuhiko Obara, Akira Matsumoto
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Patent number: 6489122Abstract: Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1, DNAs encoding the antigenic polypeptides, or DNAs complementary thereto; a method for detection and/or measurement of an anti-Chlamydia pneumoniae antibody, wherein the antigenic polypeptide is used as an antigen; reagents for detection and/or measurement of an anti-Chlamydia pneumoniae antibody, which comprise the antigenic polypeptide as an antigen; agents for diagnosis of Chlamydia pneumoniae infections, which comprise the antigenic polypeptide as an active ingredient; fused proteins of an antigenic polypeptide of Chlamydia pneumoniae with dihydrotolate reductase, in which polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1 is bound to the polypeptide of SEQ ID NO: 14 either directly or via an intervening amino acid or amino acid sequence; DNAs encoding the fused proteins, or DNAs coType: GrantFiled: October 12, 2000Date of Patent: December 3, 2002Assignee: Hitachi Chemical Company, Ltd.Inventors: Hiroshi Izutsu, Kazuhiko Obara, Akira Matsumoto
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Patent number: 6485914Abstract: Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding the antigenic polypeptides, or DNAs complementary thereto; DNAs encoding the probes and primers for detection and/or measurement of Chlamydia pneumoniae gene. The present invention further provides a method for detection and/or measurement of Chlamydia pneumoniae gene, wherein the probe or primer is used; reagents for detection and/or measurement of Chlamydia pneumoniae gene, which comprise the probe or primer; and agents for diagnosis of Chlamydia pneumoniae infections, which comprise the probe or primer as an active ingredient.Type: GrantFiled: October 12, 2000Date of Patent: November 26, 2002Assignee: Hitachi Chemical Company, Ltd.Inventors: Hiroshi Izutsu, Kazuhiko Obara, Akira Matsumoto
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Patent number: 6165478Abstract: Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding said antigenic polypeptides, or DNAs complementary thereto; recombinant vectors carrying said DNAs; transformants containing said recombinant vectors; a method for production of an anti-Chlamydia pneumoniae antibody, wherein the antigenic polypeptide is used as an antigen; fused proteins of an antigenic polypeptide of Chlamydia pneumoniae with dihydrofolate reductase, in which polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1 is bound to the polypeptide of SEQ ID NO: 14 either directly or via an intervening amino acid or amino acid sequence; DNAs encoding the fused proteins, or DNAs complementary thereto; recombinant vectors carrying the DNAs; transformants containing said recombinant vectors; a method for production of an anti-Chlamydia pneumoniae antibody; probes and pType: GrantFiled: March 19, 1997Date of Patent: December 26, 2000Assignee: Hitachi Chemical Company, Ltd.Inventors: Hiroshi Izutsu, Kazuhiko Obara, Akira Matsumoto
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Patent number: 6146839Abstract: The present invention relates to a Chlamydia pneumoniae antigen comprising protein derived from the outer membrane of Chlamydia pneumoniae, a method for producing a Chlamydia pneumoniae antigen which comprises solubilizing the cytosol and the cytoplasmic membrane of Chlamydia pneumoniae elementary body with an ionic detergent, and then removing the solubilized portion to obtain the residue, a method for measuring an anti-Chlamydia pneumoniae antibody which comprises using the Chlamydia pneumoniae antigen, and a reagent for measuring anti-Chlamydia pneumoniae antibody, said reagent comprising the Chlamydia pneumoniae antigen.In accordance with the present invention, there are provided a Chlamydia pneumoniae antigen which has a high species-specificity, very few clinically problematic false negatives, and few false positives, a method for producing said antigen, a method for measuring an anti-Chlamydia pneumoniae antibody, and a reagent for measuring an anti-Chlamydia pneumoniae antibody.Type: GrantFiled: September 26, 1997Date of Patent: November 14, 2000Assignee: Hitachi Chemical Company, Ltd.Inventors: Toshihide Morikawa, Kiyotaka Kawagoe, Hiroshi Izutsu, Akifumi Iguchi, Mitsuo Yamaki