Patents by Inventor Hiroshi Kaetsu
Hiroshi Kaetsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9775884Abstract: A fibrinogen preparation is provided which has an improved solubility, may be prepared within a short time and may be used rapidly in clinical set-up. A solid fibrinogen preparation comprising as a main ingredient fibrinogen and further containing the following components: albumin; a nonionic surfactant; a basic amino acid or a salt thereof; and at least two amino acids or a salt thereof selected from an acidic amino acid or a salt thereof and a neutral amino acid or a salt thereof. The solid fibrinogen composition of the present invention may be held on a medical material to form a supporting material holding fibrinogen. Besides, the supporting material holding fibrinogen may be combined with a component comprising as a main ingredient thrombin to provide a fibrin adhesive.Type: GrantFiled: March 21, 2008Date of Patent: October 3, 2017Assignee: The Chemo-Sero-Therapeutic Research InstituteInventors: Shinichi Miyagawa, Tatsuya Araki, Tsutomu Hamuro, Mika Okuda, Hiroshi Kaetsu
-
Patent number: 8043629Abstract: A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.Type: GrantFiled: November 16, 2007Date of Patent: October 25, 2011Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research InstituteInventors: Takanori Uchida, Noriko Shinya, Hiroshi Kaetsu, Takayuki Imamura, Chikateru Nozaki
-
Publication number: 20100119563Abstract: A fibrinogen preparation is provided which has an improved solubility, may be prepared within a short time and may be used rapidly in clinical set-up. A solid fibrinogen preparation comprising as a main ingredient fibrinogen and further containing the following components: albumin; a nonionic surfactant; a basic amino acid or a salt thereof; and at least two amino acids or a salt thereof selected from an acidic amino acid or a salt thereof and a neutral amino acid or a salt thereof. The solid fibrinogen composition of the present invention may be held on a medical material to form a supporting material holding fibrinogen. Besides, the supporting material holding fibrinogen may be combined with a component comprising as a main ingredient thrombin to provide a fibrin adhesive.Type: ApplicationFiled: March 21, 2008Publication date: May 13, 2010Applicant: Juridical Fdn. The Chemo-Sero-Therap Res. Ins.Inventors: Shinichi Miyagawa, Tatsuya Araki, Tsutomu Hamuro, Mika Okuda, Hiroshi Kaetsu
-
Publication number: 20080286347Abstract: A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.Type: ApplicationFiled: November 16, 2007Publication date: November 20, 2008Applicant: JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Takanori UCHIDA, Noriko Shinya, Hiroshi Kaetsu, Takayuki Imamura, Chikateru Nozaki
-
Publication number: 20060127460Abstract: A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.Type: ApplicationFiled: November 12, 2003Publication date: June 15, 2006Applicant: JURIDICAL FOUNDATION THE CHEMOSERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Takanori Uchida, Noriko Shinya, Hiroshi Kaetsu, Takayuki Imamura, Chikateru Nozaki
-
Publication number: 20060051340Abstract: A safe and effective hemostatic material is provided. A hemostatic material comprising as an effective ingredient thrombin and fibrinogen characterized in that a bioabsorbable synthetic nonwoven fabric is used as a supporting material. The use of the hemostatic material of the present invention allows for quick and thorough hemostasis for both projectile bleeding and exudative bleeding.Type: ApplicationFiled: January 16, 2004Publication date: March 9, 2006Applicant: Juridical Foundation The Chemo-Sero-Therapeutic Research InstituteInventors: Takanori Uchida, Noriko Shinya, Hiroshi Kaetsu
-
Patent number: 6251370Abstract: An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a thrombin solution which solutions are separated from each other. The adhesive is to be mixed and spray coated together with a sterile gas and has a volume ratio of the fibrinogen solution to the thrombin solution of about 2:1 to 10:1. This adhesive is to be sprayed together with a sterile gas for the adhesion or closing of living tissue of a human being or animal.Type: GrantFiled: April 28, 1999Date of Patent: June 26, 2001Assignee: Juridical Foundation The Chemosero Therapeutic Research InstituteInventors: Takanori Uchida, Hiroshi Kaetsu, Nobuto Fukunaga, Noriko Shinya, Takahiro Sakamoto
-
Patent number: 5980866Abstract: An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a thrombin solution which solutions are separated from each other. The adhesive is to be mixed and spray coated together with a sterile gas and has a volume ratio of the fibrinogen solution to the thrombin solution of about 2:1 to 10:1. This adhesive is to be sprayed together with a sterile gas for the adhesion or closing of living tissue of a human being or animal.Type: GrantFiled: November 13, 1997Date of Patent: November 9, 1999Assignee: Juridical Foundation The Chemosero-Therapeutic Research InstituteInventors: Takanori Uchida, Hiroshi Kaetsu, Nobuto Fukunaga, Noriko Shinya, Takahiro Sakamoto
-
Patent number: 5811279Abstract: A method for activating prothrombin to thrombin is presented which comprises treating an aqueous solution containing prothrombin with polyethylene glycol in the presence or absence of the calcium salt. The method enables conversion of prothrombin to thrombin in the absence of thromboplastin and allows for preparation of thrombin on an industrially large scale from easily available starting materials.Type: GrantFiled: August 1, 1997Date of Patent: September 22, 1998Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research InstituteInventors: Hiroshi Kaetsu, Jun Mizuguchi, Takayoshi Hamamoto