Patents by Inventor Hiroshi Kosuzume

Hiroshi Kosuzume has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5064953
    Abstract: The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton.The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: November 12, 1991
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Masahiro Mizota, Yasuo Suzuki, Ei Mochida
  • Patent number: 5001121
    Abstract: The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.The present invention is based on the selection of groups containing a condensed heterocyclic ring, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring, as substituents at the 3-position of the cephem skeleton, and of groups containing a catechol moiety, particularly a catechol carboxymethyloxyimino moiety or a catechol carboxyimino moiety, as substituents at the 7-position of the cephem skeleton.The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against Gram-negative bacteria and also against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: March 19, 1991
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Masahiro Mizota, Yasuo Suzuki, Ei Mochida
  • Patent number: 4956474
    Abstract: The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.The present invention is based on the selection of groups containing a condensed heterocyclic ring, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring, as substituents at the 3-position of the cephem skeleton, and of groups containing a catechol moiety, particularly a catechol carboxymethyloxyimino moiety or a catechol carboxyimino moiety, as substituents at the 7-position of the cephem skeleton.The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against Gram-negative bacteria and also against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: September 11, 1990
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Masahiro Mizota, Yasuo Suzuki, Ei Mochida
  • Patent number: 4904791
    Abstract: The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.The present invention is based on the selection of groups containing a condensed heterocyclic ring, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring, as substituents at the 3-position of the cephem skeleton, and of groups containing a catechol moiety, particularly a catechol carboxymethyloxyimino moiety or a catechol carboxyimino moiety, as substituents at the 7-position of the cephem skeleton.The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against Gram-negative bacteria and also against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus.
    Type: Grant
    Filed: March 28, 1988
    Date of Patent: February 27, 1990
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Masahiro Mizota, Yasuo Suzuki, Ei Mochida
  • Patent number: 4888332
    Abstract: The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton.The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus.
    Type: Grant
    Filed: December 28, 1984
    Date of Patent: December 19, 1989
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Masahiro Mizota, Yasuo Suzuki, Ei Mochida
  • Patent number: 4840945
    Abstract: The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.The present invention is based on the selection of groups containing a condensed heterocyclic ring, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring, as substituents at the 3-position of the cephem skeleton, and of groups containing a catechol moiety, particularly a catechol carboxymethyloxyimino moiety or a catechol carboxyimino moiety, as substituents at the 7-position of the cephem skeleton.The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against Gram-negative bacteria and also against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: June 20, 1989
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Masahiro Mizota, Yasuo Suzuki, Ei Mochida
  • Patent number: 4608253
    Abstract: The present invention relates to immobilized pepsin for use in removing immune complex which comprises pepsin fixed on a suitable carrier, and to a process for removing immune complex which comprises bringing blood or plasma from a patient suffering from an immune complex disease, such as rheumatoid arthritis and systemic erythematosus, into contact with the immobilized pepsin.
    Type: Grant
    Filed: November 15, 1983
    Date of Patent: August 26, 1986
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Yasuo Suzuki, Ei Mochida
  • Patent number: 4591504
    Abstract: This invention provides a human leucocyte pepsin-like enzyme and a therapeutic agent and method for treating allergic disorders, immune complex diseases and tumors, the agent containing the enzyme as an effective ingredient. The human leucocyte pepsin-like enzyme of this invention is a protein of human origin and, therefore, a therapeutic agent containing said enzyme as an effective ingredient shows extremely little adverse reactions such as anaphylaxis and thus is highly safe.
    Type: Grant
    Filed: May 26, 1983
    Date of Patent: May 27, 1986
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Yasuo Suzuki, Ei Mochida
  • Patent number: 4540569
    Abstract: Therapeutic agent for the treatment of allergic disorders, immune complex diseases and tumors, which contains a human urinary acid protease as an active ingredient, and a method for treating allergic disorders, immune complex diseases and tumors by administering the said acid protease, which has never been used as a therapeutic agent for allergic disorders, immune complex diseases and tumors. Since the acid protease is a protein of human origin, the probability of adverse reactions such as anaphylactic shock due to the antigenicity of the acid protease is believed to be extremely small.
    Type: Grant
    Filed: April 5, 1982
    Date of Patent: September 10, 1985
    Assignee: Mochida Seiyaku Kabushiki Kaisha
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Yasuo Suzuki, Ei Mochida
  • Patent number: 4534966
    Abstract: There are provided a pharmaceutical composition having an effect to control phagocytic function, which comprises a pharmaceutically effective amount of human pepsin and/or a human leukocyte pepsin-like enzyme and a pharmaceutically acceptable carrier, and a therapeutic method using said composition. The pharmaceutical composition is useful for treatment of infectious diseases, gout and arteriosclerosis.
    Type: Grant
    Filed: November 17, 1983
    Date of Patent: August 13, 1985
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Yasuo Suzuki, Ei Mochida
  • Patent number: 4476127
    Abstract: The compound related to this invention is 7-diethylamino-5-methyl-thiazolo[5,4-d]pyrimidine.The compound related to this invention possesses vasodilating action, hypotensive action, inhibitory action on platelet aggregation, and lowering action on cholesterol levels in blood, and is useful as a therapeutic agent for cardiovascular diseases.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: October 9, 1984
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Yasuo Suzuki, Ei Mochida
  • Patent number: 4440770
    Abstract: A pharmaceutical composition having diuretic, hypotensive and antiedemic effects which contains a 6-halo-4-oximino-1,2,3,4-tetrahydroquinoline derivative or a salt thereof, and a method to use the above-described derivative or a salt thereof as a diuretic, hypotensive and antiedemic agent.
    Type: Grant
    Filed: July 7, 1981
    Date of Patent: April 3, 1984
    Assignee: Mochida Seiyaku Kabushiki Kaisha
    Inventors: Ei Mochida, Haruo Ohnishi, Kazuo Yamaguchi, Yasuo Suzuki, Hiroshi Kosuzume
  • Patent number: 4436724
    Abstract: A method of producing .gamma.-globulin which can be administered intravenously without adverse reactions and loss of opsonic activity is provided. The method comprises treating .gamma.-globulin with pepsin or uropepsin in a neutral pH range of 6.0 to 7.5. The aggregates in .gamma.-globulin are selectively decomposed by the method of the present invention, while any decomposition of monomer .gamma.-globulin molecule is substantially prevented. A therapeutic agent for intravenous injection which is reduced its anticomplementary activity and is stabilized by adding uropepsin which serves simultaneously as a proteolytic enzyme and a stabilizer, to human .gamma.-globulin. Uropepsinogen can be also as a stabilizer.
    Type: Grant
    Filed: May 26, 1982
    Date of Patent: March 13, 1984
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Haruo Ohnishi, Hiroshi Kosuzume, Yasuo Suzuki, Ei Mochida
  • Patent number: 4315003
    Abstract: The compositions for therapeutic treatment contain as an active ingredient a 2-[(2-methoxyphenyl)-axo]-1H-imidazole derivative of the formula: ##STR1## wherein X is hydrogen or halogen, or a pharmaceutically acceptable salt thereof. This compound is effective for the therapeutic treatment of edema, hypotension, cardiac insufficiency and mucosa hyperemia.
    Type: Grant
    Filed: July 29, 1980
    Date of Patent: February 9, 1982
    Assignee: Mochida Seiyaku Kabushiki Kaisha
    Inventors: Ei Mochida, Yasuo Suzuki, Haruo Onishi, Hiroshi Kosuzume