Patents by Inventor Hiroshi Kurono
Hiroshi Kurono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965899Abstract: Disclosed is a calibration curve setting method for setting a calibration curve, the calibration curve setting method including: creating a first calibration curve on the basis of a measurement value obtained by measuring a standard sample for which a concentration of a predetermined component is known; creating a second calibration curve by correcting the created first calibration curve; displaying a screen configured to support an operator for restoring the second calibration curve to the first calibration curve; receiving an instruction of restoring the second calibration curve to the first calibration curve; and displaying the first calibration curve upon receiving the instruction of restoring.Type: GrantFiled: August 31, 2021Date of Patent: April 23, 2024Assignee: SYSMEX CORPORATIONInventors: Akihito Kato, Hiroshi Kurono
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Patent number: 11933797Abstract: Disclosed is a calibration curve creation method performed by an analyzer, the calibration curve creation method including: preparing a plurality of calibrators at different dilution rates by dispensing a calibrator in a container into one or more different containers; obtaining a plurality of measurement values by measuring each of the prepared plurality of calibrators; creating a calibration curve by use of the plurality of measurement values; selecting a first measurement value to be re-measured, among the plurality of measurement values used for the calibration curve; preparing another calibrator at a dilution rate corresponding to a calibrator from which the selected first measurement value is obtained; obtaining a second measurement value by measuring the prepared another calibrator; and creating a new calibration curve by replacing the first measurement value, among the plurality of measurement values, with the second measurement value.Type: GrantFiled: September 18, 2019Date of Patent: March 19, 2024Assignee: SYSMEX CORPORATIONInventors: Kazuma Moriura, Hiroshi Kurono
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Patent number: 11919917Abstract: A drug or agent containing a compound having an agonistic activity to STING as an active ingredient, where the compound is represented by the following general formula (I-1): wherein all symbols represent the same meanings as described in the specification, and the compound can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.Type: GrantFiled: August 6, 2021Date of Patent: March 5, 2024Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Ryosuke Hanada, Masaya Kokubo, Masakuni Kurono, Kenichi Kouda, Hiroshi Hagiya
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Patent number: 11747350Abstract: A blood coagulation analyzing method according to one or more aspects may include: calculating a coagulation time based on data representing a coagulation curve of a change in an optical detection value of a blood specimen added with a reagent for starting a coagulation reaction; calculating an index value related to derivatives calculated concerning the coagulation curve represented by the data used in the calculating the coagulation time; and determining whether an early reaction error has occurred based on a comparison result obtained by comparing the index value to a predetermined threshold.Type: GrantFiled: September 26, 2019Date of Patent: September 5, 2023Assignee: SYSMEX CORPORATIONInventors: Hiroshi Kurono, Keiichi Yamaguchi
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Patent number: 11604201Abstract: Disclosed is a specimen analyzer configured to perform analysis on a specimen for a plurality of measurement items, the specimen analyzer including a measurement section configured to perform a specimen measurement for measuring a measurement sample prepared from a specimen and a reagent corresponding to a measurement item, and configured to perform a quality control measurement for measuring a measurement sample prepared from a quality control substance and a reagent corresponding to a measurement item; and a controller programmed to set a quality control for each measurement item, from a quality control group that includes at least two types of quality controls selected from a first quality control in which the quality control measurement is performed at a predetermined time, a second quality control in which the quality control measurement is performed every time the specimen measurement is performed a predetermined number of times of measurement, and a third quality control in which the quality control meType: GrantFiled: November 27, 2019Date of Patent: March 14, 2023Assignee: SYSMEX CORPORATIONInventor: Hiroshi Kurono
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Patent number: 11333675Abstract: A sample analyzer comprises a container setting part on which a liquid container is to be set, a liquid supplying part configured to supply a liquid to the liquid container, an aspiration tube configured to aspirate a sample or a reagent, a movement mechanism configured to move the aspiration tube, a liquid surface sensor configured to detect contact of the aspiration tube with a liquid surface, and a controller configured to execute an aspiration tube adjustment operation. The aspiration tube adjustment operation comprises supplying the liquid to the liquid container by the liquid supplying part, lowering the aspiration tube by the movement mechanism toward the liquid container set on the container setting part, and obtaining information regarding a position in a height direction of the aspiration tube at a time when the aspiration tube has come into contact with the liquid surface.Type: GrantFiled: May 13, 2019Date of Patent: May 17, 2022Assignee: SYSMEX CORPORATIONInventors: Miyuki Yamada, Shuji Kawaguchi, Hiroshi Kurono
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Patent number: 11268949Abstract: A blood analysis method includes: acquiring optical information which changes over time from a mixed liquid of a blood sample and a reagent for coagulation time measurement after mixing the blood sample and the reagent, and acquiring information related to a coagulation time and information related to a number of platelets in the blood sample based on the acquired optical information.Type: GrantFiled: April 16, 2019Date of Patent: March 8, 2022Assignees: SYSMEX CORPORATION, UNIVERSITY OF YAMANASHIInventors: Takeshi Suzuki, Yutaka Komiyama, Hiroshi Kurono, Sho Shinohara, Kaneo Satoh, Fuminori Kazama, Yugo Shimada
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Publication number: 20220065881Abstract: Disclosed is a calibration curve setting method for setting a calibration curve, the calibration curve setting method including: creating a first calibration curve on the basis of a measurement value obtained by measuring a standard sample for which a concentration of a predetermined component is known; creating a second calibration curve by correcting the created first calibration curve; displaying a screen configured to support an operator for restoring the second calibration curve to the first calibration curve; receiving an instruction of restoring the second calibration curve to the first calibration curve; and displaying the first calibration curve upon receiving the instruction of restoring.Type: ApplicationFiled: August 31, 2021Publication date: March 3, 2022Applicant: SYSMEX CORPORATIONInventors: Akihito KATO, Hiroshi KURONO
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Publication number: 20220065882Abstract: Disclosed is a method for displaying calibration curve including: measuring a standard sample that contains a known concentration of a component, and creating a calibration curve before being validated, based on a measurement result of the standard sample and the known concentration of the component in the standard sample; measuring a quality control sample that contains a component having a known concentration, and obtaining a quality control result representing a concentration of the component in the quality control sample by converting a measurement result of the quality control sample into concentration based on the calibration curve before being validated; and displaying a screen including the calibration curve before being validated and the quality control result.Type: ApplicationFiled: August 31, 2021Publication date: March 3, 2022Applicant: SYSMEX CORPORATIONInventors: Akihito KATO, Hiroshi KURONO
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Patent number: 10908175Abstract: A sample analyzer is configured to execute a liquid surface detection of detecting a liquid surface in a container by a liquid surface detector prior to a lowering operation of an aspirating tube for aspirating the liquid if a liquid level information is not stored in a memory, and store a liquid level information of a container in the memory based on a detection result by the liquid surface detection. Also, a liquid aspirating method by a sample analyzer.Type: GrantFiled: November 23, 2016Date of Patent: February 2, 2021Assignee: SYSMEX CORPORATIONInventors: Hiroshi Kurono, Takashi Yamato
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Publication number: 20200400702Abstract: Disclosed is a specimen measurement method for measuring platelet aggregation of a specimen, and the specimen measurement method includes: automatically preparing a diluted reagent solution that contains a platelet-aggregating reagent diluted with a diluent; preparing a measurement sample that contains a predetermined concentration of the platelet-aggregating reagent, from the diluted reagent solution and the specimen; and performing optical measurement of the measurement sample.Type: ApplicationFiled: May 18, 2020Publication date: December 24, 2020Applicant: SYSMEX CORPORATIONInventors: Hiroshi KURONO, Tasuku SAKAYORI, Yuri WATANABE
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Publication number: 20200278363Abstract: Disclosed is a sample analyzer including a storage section configured to store a plurality of containers for containing a sample, and including a discharge port through which the container is discharged; a production lot information acquisition unit that acquires production lot information on a production lot of the container; an analysis processing unit that performs analysis processing of the sample contained in the container discharged through the discharge port; a recorder that records the production lot information, an analysis result of the sample contained in the container, and time information related to time of analyzing the sample; and a display information generation unit that generates, based on information recorded in the recorder, display information for displaying at least one analysis result of at least one sample analyzed during a period of time on a display unit in a manner that associates the at least one analysis result with the production lot information.Type: ApplicationFiled: February 25, 2020Publication date: September 3, 2020Inventors: Kazuma MORIURA, Hiroshi KURONO
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Publication number: 20200174028Abstract: Disclosed is a specimen analyzer configured to perform analysis on a specimen for a plurality of measurement items, the specimen analyzer including a measurement section configured to perform a specimen measurement for measuring a measurement sample prepared from a specimen and a reagent corresponding to a measurement item, and configured to perform a quality control measurement for measuring a measurement sample prepared from a quality control substance and a reagent corresponding to a measurement item; and a controller programmed to set a quality control for each measurement item, from a quality control group that includes at least two types of quality controls selected from a first quality control in which the quality control measurement is performed at a predetermined time, a second quality control in which the quality control measurement is performed every time the specimen measurement is performed a predetermined number of times of measurement, and a third quality control in which the quality control meType: ApplicationFiled: November 27, 2019Publication date: June 4, 2020Inventor: Hiroshi KURONO
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Publication number: 20200103429Abstract: A method according to one or more aspects may be for displaying measurement results of measurement items by a sample analyzer. The method may include displaying each of the measurement items selectably on a display unit, and displaying a notification concerning any of the measurement results in association with the corresponding measurement item on the display unit; and in response to selection of at least one of the measurement items, displaying the measurement result of the selected at least one of the measurement items on the display unit.Type: ApplicationFiled: September 25, 2019Publication date: April 2, 2020Applicant: SYSMEX CORPORATIONInventors: Kazuma MORIURA, Hiroshi KURONO, Akihito KATO
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Publication number: 20200103428Abstract: Disclosed is a calibration curve creation method performed by an analyzer, the calibration curve creation method including: preparing a plurality of calibrators at different dilution rates by dispensing a calibrator in a container into one or more different containers; obtaining a plurality of measurement values by measuring each of the prepared plurality of calibrators; creating a calibration curve by use of the plurality of measurement values; selecting a first measurement value to be re-measured, among the plurality of measurement values used for the calibration curve; preparing another calibrator at a dilution rate corresponding to a calibrator from which the selected first measurement value is obtained; obtaining a second measurement value by measuring the prepared another calibrator; and creating a new calibration curve by replacing the first measurement value, among the plurality of measurement values, with the second measurement value.Type: ApplicationFiled: September 18, 2019Publication date: April 2, 2020Inventors: Kazuma MORIURA, Hiroshi KURONO
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Publication number: 20200103420Abstract: A blood coagulation analyzing method according to one or more aspects may include: calculating a coagulation time based on data representing a coagulation curve of a change in an optical detection value of a blood specimen added with a reagent for starting a coagulation reaction; calculating an index value related to derivatives calculated concerning the coagulation curve represented by the data used in the calculating the coagulation time; and determining whether an early reaction error has occurred based on a comparison result obtained by comparing the index value to a predetermined threshold.Type: ApplicationFiled: September 26, 2019Publication date: April 2, 2020Applicant: SYSMEX CORPORATIONInventors: Hiroshi KURONO, Keiichi YAMAGUCHI
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Publication number: 20200104031Abstract: A display method according to one or more aspects may be a method used in a sample analyzer comprising holders configured to hold reagent containers of reagents used for an analysis of a sample. The display method may include: displaying, on a display unit, icons respectively associated with the holders; receiving selection of icons from the icons displayed on the display unit; and receiving an instruction for a predetermined operation relevant to the selected icons.Type: ApplicationFiled: September 26, 2019Publication date: April 2, 2020Applicant: SYSMEX CORPORATIONInventors: Kazuma MORIURA, Hiroshi KURONO, Akihito KATO
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Publication number: 20190331659Abstract: A blood analysis method comprising, acquiring optical information which changes over time from a mixed liquid of a blood sample and a reagent for coagulation time measurement after mixing the blood sample and the reagent, and acquiring information related to a coagulation time and information related to a number of platelets in the blood sample based on the acquired optical information.Type: ApplicationFiled: April 16, 2019Publication date: October 31, 2019Applicants: SYSMEX CORPORATION, University of YamanashiInventors: Takeshi Suzuki, Yutaka Komiyama, Hiroshi Kurono, Sho Shinohara, Kaneo Satoh, Fuminori Kazama, Yugo Shimada
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Publication number: 20190265265Abstract: A sample analyzer comprises a container setting part on which a liquid container is to be set, a liquid supplying part configured to supply a liquid to the liquid container, an aspiration tube configured to aspirate a sample or a reagent, a movement mechanism configured to move the aspiration tube, a liquid surface sensor configured to detect contact of the aspiration tube with a liquid surface, and a controller configured to execute an aspiration tube adjustment operation. The aspiration tube adjustment operation comprises supplying the liquid to the liquid container by the liquid supplying part, lowering the aspiration tube by the movement mechanism toward the liquid container set on the container setting part, and obtaining information regarding a position in a height direction of the aspiration tube at a time when the aspiration tube has come into contact with the liquid surface.Type: ApplicationFiled: May 13, 2019Publication date: August 29, 2019Inventors: Miyuki YAMADA, Shuji KAWAGUCHI, Hiroshi KURONO
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Patent number: 10215766Abstract: Disclosed is a blood sample determination method including: emitting light to a measurement specimen prepared by mixing a clotting time measuring reagent and a blood sample suspected to be derived from a subject having lupus anticoagulant or a coagulation factor inhibitor, to obtain optical information about an amount of light from the measurement specimen; obtaining at least one parameter regarding derivative of clot waveform, based on the obtained optical information; and determining, based on a value of the obtained parameter, whether the blood sample is suspected to be a sample derived from a subject having lupus anticoagulant or is suspected to be a sample derived from a subject having a coagulation factor inhibitor.Type: GrantFiled: December 15, 2015Date of Patent: February 26, 2019Assignees: PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY, SYSMEX CORPORATIONInventors: Midori Shima, Keiji Nogami, Yuka Tabuchi, Hiroshi Kurono