Abstract: A biostimulation apparatus of the present invention includes a laser oscillator for oscillating an ultra short pulsed laser beam and an optical system for focusing the ultra short pulsed laser beam, wherein the ultra short pulsed laser beam is focused by the optical system at a target portion of a living subject to cause the target portion to be irradiated with the laser beam to stimulate an acupuncture point, and wherein the target portion is either the acupuncture point or its periphery.

Abstract: The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.

Abstract: A biostimulation apparatus of the present invention includes a laser oscillator for oscillating an ultra short pulsed laser beam and an optical system for focusing the ultra short pulsed laser beam, wherein the ultra short pulsed laser beam is focused by the optical system at a target portion of a living subject to cause the target portion to be irradiated with the laser beam to stimulate an acupuncture point, and wherein the target portion is either the acupuncture point or its periphery.

Abstract: An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.

Abstract: (Problems) To provide a cell fusion chip, which allows to perform a cell fusion on a single chip, excels in the operating efficiency, does not require experience so much in cell feed or recovery, and has no risk of the contamination to the cells during the operation. (Means for Solving Problems) The present invention provides a cell fusion chip comprising: an isolation chamber for receiving isolated cells to be subjected to an fusion operation; a fusion chamber for fusing the cells together supplied from the isolation chamber; a culture chamber for culturing the cells fused in the fusion chamber; a first channel for connecting the isolation chamber and the fusion chamber; and a second channel for connecting the fusion chamber and the culture chamber, wherein the isolation chamber, the fusion chamber, the culture chamber, the first channel and the second channel are formed on a single chip.

Abstract: A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.

Abstract: A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.

Abstract: The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.

Abstract: An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.

Abstract: The present invention relates to a process for producing high-quality crystals of protein or organic substances easily and efficiently. A solution of protein or an organic substance is prepared and then is cooled slowly to be supersaturated to a low degree. This supersaturated solution is irradiated with a femtosecond laser 10. A local explosion phenomenon occurs at the focal point of the laser and thereby a crystalline nucleus is generated. A high-quality crystal is obtained when a crystal is grown on the crystalline nucleus over a long period of time. The femtosecond laser to be used herein can be a titanium:sapphire laser having a wavelength of 800 nm, a duration of 120 fs, a frequency of 1 kHz, and an output of 400 mW.

Abstract: The present invention relates to a process for producing high-quality crystals of protein or organic substances easily and efficiently. A solution of protein or an organic substance is prepared and then is cooled slowly to be supersaturated to a low degree. This supersaturated solution is irradiated with a femtosecond laser 10. A local explosion phenomenon occurs at the focal point of the laser and thereby a crystalline nucleus is generated. A high-quality crystal is obtained when a crystal is grown on the crystalline nucleus over a long period of time. The femtosecond laser to be used herein can be a titanium:sapphire laser having a wavelength of 800 nm, a duration of 120 fs, a frequency of 1 kHz, and an output of 400 mW.

Abstract: To derive spectrum information on chemical intermediates in photochemical reactions during transitional periods, a transient grating spectroscopy uses white light as the probe light in the pico-second region and monochromatic light in the microsecond region. According to the procedure, it is possible to analyze the photochemical reaction of thin films and interface layers as a function of time at a high precision.

Abstract: A method of spectrometry is disclosed for measuring transient absorbance and transient absorption spectrum of a substance to be measured at interfaces in liquid phase of particulates containing a fluorescent pigment and the substance to be measured by the utilization of optical resonance phenomenon. An apparatus for carrying out the method is also disclosed and comprises: (a) a pulse laser oscillator for exciting the fluorescent pigment and the substance to be measured, respectively; (b) an optical delay device for causing delay of any one of pulse laser beams of two kinds of wavelengths generated by the pulse laser oscillator; (c) a microscope system for condensing laser beams generated by the pulse laser oscillator and irradiating the condensed beams to the sample; and (d) a detector for detecting light emission of the sample.

Abstract: The present invention provides microprocessing and the device therefor which is characterized by radiating proessing pulse laser together with trapping laser to perform the modification and processing of particles and micropcapsules.In the case of using such method for implosion, the reaction group is caused to be released by imploding the micro capsule with the reactive goup enclosed to implosion, permitting specified reaction and processing.

Abstract: The present invention provides microprocessing and the device therefor which is characterized by radiating proessing pulse laser together with trapping laser to perform the modification and processing of particles and microcapsules.In the case of using such method for implosion, the reaction group is caused to be released by imploding the microcapsule with the reactive goup enclosed to implosion, permitting specified reaction and processing.