Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: An R-T-B based sintered magnet includes a first main surface and a first side surface. The first main surface has a coercivity that is higher than that of the first side surface. ?HcjM?60 kA/m is satisfied, where ?HcjM is a difference in coercivity between a portion having a highest coercivity on the first main surface and a portion having a lowest coercivity on the first main surface. ?HcjG?60 kA/m is satisfied, where ?HcjG is a difference in coercivity between a portion having a highest coercivity on a first cross section and a portion having a lowest coercivity on the first cross section and the first cross section is a cross section parallel to the first main surface and spaced from the first main surface at a predetermined length or more.

Abstract: A method of processing a rare earth magnet comprises: a step of irradiating an R-T-B-based rare earth magnet with laser light to process; and a step of performing heat treatment on the magnet after the irradiating. The heat treatment includes: a step A of bringing the temperature of the magnet to 400° C. or less, a step B of holding the magnet at a temperature T1 in a range of 400 to 700° C. after the step A, and a step C of bringing the temperature of the magnet to less than 400° C. after the step B. The temperature of the magnet is made not to exceed 700° C. between the step A and the step B. The temperature of the magnet is made not to exceed 700° C. between the step B and the step C. A step of setting the magnet at a temperature higher than 700° C. after the step C is not included.

Abstract: Problem A sub clock for a sleep mode in a a microcomputer is retained to be operable with high accuracy. Solution A sub clock 20 counts oscillating pulses of a CR oscillating circuit 21 by a loop counter 22, and outputs a clock signal each time the oscillating pulses reach a target count Pm. A CPU 11 counts oscillating pulses of the CR oscillating circuit 21 in a predetermined time measured by a time counter 25 in response to a clock signal of a main clock 13 by a crystal oscillator, and corrects the target count Pm according to a pulse count P thereof. Since the real count state is obtained based upon the clock signal of the main clock having high frequency accuracy without the estimation of the sub clock 20, the high accuracy of the sub clock is retained even if environmental changes such as temperatures occur.

Abstract: An R-T-B based sintered magnet includes a first main surface and a first side surface. The first main surface has a coercivity that is higher than that of the first side surface. ?HcjM?60 kA/m is satisfied, where ?HcjM is a difference in coercivity between a portion having a highest coercivity on the first main surface and a portion having a lowest coercivity on the first main surface. ?HcjG?60 kA/m is satisfied, where ?HcjG is a difference in coercivity between a portion having a highest coercivity on a first cross section and a portion having a lowest coercivity on the first cross section and the first cross section is a cross section parallel to the first main surface and spaced from the first main surface at a predetermined length or more.

Abstract: A sub clock 20 counts oscillating pulses of a CR oscillating circuit 21 by a loop counter 22, and outputs a clock signal each time the oscillating pulses reach a target count Pm. A CPU 11 counts oscillating pulses of the CR oscillating circuit 21 in a predetermined time measured by a time counter 25 in response to a dock signal of a main clock 13 by a crystal oscillator, and corrects the target count Pm according to a pulse count P thereof. Since the real count state is obtained based upon the clock signal of the main clock having high frequency accuracy without the estimation of the sub clock 20, the high accuracy of the sub clock is retained even if environmental changes such as temperatures occur.

Abstract: A sound generating circuit for a timepiece including a sound base signal generator, a program divider, a dividing ratio selecting counter a sound interval base signal generator and a sound producer, whereby the sounding action of frequencies which repeatedly changes at the sound intervals and cycles is performed and can produce the onomatopoetic sounds of bird chirp, insect churr and the like which feels soft and soothing for the users.

Abstract: A time correction circuit for a timepiece with an electrochromic display which includes a timing circuit having counters counting time standard clock signals and for generating time display output signals, a time display circuit having an electrochromic display section displaying output signals from said counters, a correction mode changeover switch selectively switching between a time display mode and a time correction mode, a correcting circuit which works only when said correction mode changeover switch selects the correction mode to change the count in the counters, a writing and erasing control circuit for controlling the timing of the writing and the erasing of the electrochromic display section in response to the mode selected by the correction mode changeover switch and a correction pulse generating circuit for outputting time correction writing pulses of smaller pulse width than time correction writing and erasing pulses during the time display mode when the correction mode changeover switch selects